| Small molecules enhance autophagy and reduce toxicity in Huntington's disease models S Sarkar, EO Perlstein, S Imarisio, S Pineau, A Cordenier, RL Maglathlin, ... Nature chemical biology 3 (6), 331-338, 2007 | 683 | 2007 |
| Global nucleosome occupancy in yeast BE Bernstein, CL Liu, EL Humphrey, EO Perlstein, SL Schreiber Genome biology 5, 1-11, 2004 | 451 | 2004 |
| A library of spirooxindoles based on a stereoselective three-component coupling reaction MMC Lo, CS Neumann, S Nagayama, EO Perlstein, SL Schreiber Journal of the American Chemical Society 126 (49), 16077-16086, 2004 | 309 | 2004 |
| Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington’s disease models and enhance killing of mycobacteria by macrophages RA Floto, S Sarkar, EO Perlstein, B Kampmann, SL Schreiber, ... Autophagy 3 (6), 620-622, 2007 | 188 | 2007 |
| Genetic basis of individual differences in the response to small-molecule drugs in yeast EO Perlstein, DM Ruderfer, DC Roberts, SL Schreiber, L Kruglyak Nature genetics 39 (4), 496-502, 2007 | 146 | 2007 |
| Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway RA Butcher, BS Bhullar, EO Perlstein, G Marsischky, J LaBaer, ... Nature chemical biology 2 (2), 103-109, 2006 | 116 | 2006 |
| Ten simple rules of live tweeting at scientific conferences S Ekins, EO Perlstein PLoS computational biology 10 (8), e1003789, 2014 | 69 | 2014 |
| Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG S Iyer, FS Sam, N DiPrimio, G Preston, J Verheijen, K Murthy, Z Parton, ... Disease models & mechanisms 12 (11), dmm040584, 2019 | 67 | 2019 |
| Harnessing gene expression to identify the genetic basis of drug resistance BJ Chen, HC Causton, D Mancenido, NL Goddard, EO Perlstein, D Pe'er Molecular systems biology 5 (1), 310, 2009 | 64 | 2009 |
| Display of functional αβ single-chain T-cell receptor molecules on the surface of bacteriophage JA Weidanz, KF Card, A Edwards, E Perlstein, HC Wong Journal of immunological methods 221 (1-2), 59-76, 1998 | 64 | 1998 |
| The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast MM Rainey, D Korostyshevsky, S Lee, EO Perlstein Genetics 185 (4), 1221-1233, 2010 | 62 | 2010 |
| Revealing complex traits with small molecules and naturally recombinant yeast strains EO Perlstein, DM Ruderfer, G Ramachandran, SJ Haggarty, L Kruglyak, ... Chemistry & biology 13 (3), 319-327, 2006 | 50 | 2006 |
| Accumulation of an antidepressant in vesiculogenic membranes of yeast cells triggers autophagy J Chen, D Korostyshevsky, S Lee, EO Perlstein PLoS One 7 (4), e34024, 2012 | 38 | 2012 |
| Anatomy of the Crowd4Discovery crowdfunding campaign EO Perlstein SpringerPlus 2 (1), 560, 2013 | 34 | 2013 |
| Defects in the Neuroendocrine Axis Contribute to Global Development Delay in a Drosophila Model of NGLY1 Deficiency TP Rodriguez, JD Mast, T Hartl, T Lee, P Sand, EO Perlstein G3: Genes, Genomes, Genetics 8 (7), 2193-2204, 2018 | 32 | 2018 |
| Sorbitol is a severity biomarker for PMM2‐CDG with therapeutic implications AN Ligezka, S Radenkovic, M Saraswat, K Garapati, W Ranatunga, ... Annals of neurology 90 (6), 887-900, 2021 | 30 | 2021 |
| Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches S Iyer, JD Mast, H Tsang, TP Rodriguez, N DiPrimio, M Prangley, FS Sam, ... Disease Models & Mechanisms 12 (11), dmm040576, 2019 | 26 | 2019 |
| Using expression and genotype to predict drug response in yeast DM Ruderfer, DC Roberts, SL Schreiber, EO Perlstein, L Kruglyak PloS one 4 (9), e6907, 2009 | 19 | 2009 |
| Yeast models of phosphomannomutase 2 deficiency, a congenital disorder of glycosylation JP Lao, N DiPrimio, M Prangley, FS Sam, JD Mast, EO Perlstein G3: Genes, Genomes, Genetics 9 (2), 413-423, 2019 | 17 | 2019 |
| Evolutionarily conserved optimization of amino acid biosynthesis EO Perlstein, BL De Bivort, S Kunes, SL Schreiber Journal of molecular evolution 65, 186-196, 2007 | 16 | 2007 |
