| Mapping allostery through the covariance analysis of NMR chemical shifts R Selvaratnam, S Chowdhury, B VanSchouwen, G Melacini Proceedings of the National Academy of Sciences 108 (15), 6133-6138, 2011 | 241 | 2011 |
| Signaling through dynamic linkers as revealed by PKA M Akimoto, R Selvaratnam, ET McNicholl, G Verma, SS Taylor, G Melacini Proceedings of the National Academy of Sciences 110 (35), 14231-14236, 2013 | 119 | 2013 |
| The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants R Selvaratnam, B VanSchouwen, F Fogolari, MT Mazhab-Jafari, R Das, ... Biophysical journal 102 (3), 630-639, 2012 | 96 | 2012 |
| A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP M Akimoto, Z Zhang, S Boulton, R Selvaratnam, B VanSchouwen, ... Journal of Biological Chemistry 289 (32), 22205-22220, 2014 | 94 | 2014 |
| Dynamically driven ligand selectivity in cyclic nucleotide binding domains R Das, S Chowdhury, MT Mazhab-Jafari, S SilDas, R Selvaratnam, ... Journal of Biological Chemistry 284 (35), 23682-23696, 2009 | 90 | 2009 |
| The auto-inhibitory role of the EPAC hinge helix as mapped by NMR R Selvaratnam, MT Mazhab-Jafari, R Das, G Melacini PloS one 7 (11), e48707, 2012 | 85 | 2012 |
| A tool set to map allosteric networks through the NMR chemical shift covariance analysis S Boulton, M Akimoto, R Selvaratnam, A Bashiri, G Melacini Scientific reports 4 (1), 7306, 2014 | 76 | 2014 |
| Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I GY Huang, JJ Kim, AS Reger, R Lorenz, EW Moon, C Zhao, DE Casteel, ... Structure 22 (1), 116-124, 2014 | 75 | 2014 |
| Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP R Das, MT Mazhab-Jafari, S Chowdhury, S SilDas, R Selvaratnam, ... Journal of biological chemistry 283 (28), 19691-19703, 2008 | 70 | 2008 |
| Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)*♦ B VanSchouwen, R Selvaratnam, R Giri, R Lorenz, FW Herberg, C Kim, ... Journal of Biological Chemistry 290 (48), 28631-28641, 2015 | 51 | 2015 |
| Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC) B VanSchouwen, R Selvaratnam, F Fogolari, G Melacini Journal of Biological Chemistry 286 (49), 42655-42669, 2011 | 50 | 2011 |
| Mechanism of selective enzyme inhibition through uncompetitive regulation of an allosteric agonist S Boulton, R Selvaratnam, JP Blondeau, F Lezoualc’h, G Melacini Journal of the American Chemical Society 140 (30), 9624-9637, 2018 | 37 | 2018 |
| A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins LA Matthews, R Selvaratnam, DR Jones, M Akimoto, BJ McConkey, ... Journal of Biological Chemistry 289 (5), 2589-2599, 2014 | 28 | 2014 |
| Mechanisms of specific versus nonspecific interactions of aggregation-prone inhibitors and attenuators S Boulton, R Selvaratnam, R Ahmed, K Van, X Cheng, G Melacini Journal of medicinal chemistry 62 (10), 5063-5079, 2019 | 23 | 2019 |
| Implementation of the NMR CHEmical shift covariance analysis (CHESCA): a chemical biologist’s approach to allostery S Boulton, R Selvaratnam, R Ahmed, G Melacini Protein NMR: Methods and Protocols, 391-405, 2018 | 23 | 2018 |
| cAMP-dependent allostery and dynamics in Epac: an NMR view R Selvaratnam, M Akimoto, B VanSchouwen, G Melacini Biochemical Society Transactions 40 (1), 219-223, 2012 | 23 | 2012 |
| Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR S Boulton, M Akimoto, B VanSchouwen, K Moleschi, R Selvaratnam, ... Biochemical Society Transactions 42 (2), 302-307, 2014 | 22 | 2014 |
| Measuring magnesium–Physiological, clinical and analytical perspectives A Dent, R Selvaratnam Clinical Biochemistry 105, 1-15, 2022 | 21 | 2022 |
| Allosteric linkers in cAMP signalling M Akimoto, K Moleschi, S Boulton, B VanSchouwen, R Selvaratnam, ... Biochemical Society Transactions 42 (1), 139-144, 2014 | 19 | 2014 |
| Ultrasonic and densimetric characterization of the association of cyclic AMP with the cAMP-binding domain of the exchange protein EPAC1 I Son, R Selvaratnam, DN Dubins, G Melacini, TV Chalikian The Journal of Physical Chemistry B 117 (37), 10779-10784, 2013 | 18 | 2013 |
Giuseppe MelaciniProfessor, McMaster UniversityVerified email at mcmaster.ca
