| Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins R Alvarez, P Puebla, JF Diaz, AC Bento, R Garcia-Navas, ... Journal of medicinal chemistry 56 (7), 2813-2827, 2013 | 77 | 2013 |
| Isocombretastatins A: 1, 1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds R Álvarez, C Álvarez, F Mollinedo, BG Sierra, M Medarde, R Peláez Bioorganic & medicinal chemistry 17 (17), 6422-6431, 2009 | 70 | 2009 |
| Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation C Álvarez, R Álvarez, P Corchete, C Pérez-Melero, R Peláez, M Medarde Bioorganic & medicinal chemistry 16 (19), 8999-9008, 2008 | 56 | 2008 |
| Phylogenetic relationships elucidate colonization patterns in the intertidal grazers Osilinus Philippi, 1847 and Phorcus Risso, 1826 (Gastropoda: Trochidae) in the northeastern … KM Donald, J Preston, ST Williams, DG Reid, D Winter, R Alvarez, B Buge, ... Molecular phylogenetics and evolution 62 (1), 35-45, 2012 | 55 | 2012 |
| Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization C Alvarez, R Alvarez, P Corchete, JL López, C Pérez-Melero, R Peláez, ... Bioorganic & medicinal chemistry 16 (11), 5952-5961, 2008 | 50 | 2008 |
| Exploring the effect of 2, 3, 4-trimethoxy-phenyl moiety as a component of indolephenstatins C Álvarez, R Álvarez, P Corchete, C Pérez-Melero, R Peláez, M Medarde European journal of medicinal chemistry 45 (2), 588-597, 2010 | 49 | 2010 |
| Effect of high temperatures on seed germination and seedling survival in three pine species (Pinus pinaster, P. sylvestris and P. nigra) R Alvarez, L Valbuena, L Calvo International Journal of Wildland Fire 16 (1), 63-70, 2007 | 49 | 2007 |
| Fluorescent bicyclic furo pyrimidine deoxynucleoside analogs as potent and selective inhibitors of VZV and potential future drugs for the treatment of chickenpox and shingles C McGuigan, A Brancale, H Barucki Drugs of the Future 25 (11), 2000 | 45 | 2000 |
| Pyridine Based Antitumour Compounds Acting at the Colchicine Site R Alvarez, R., Aramburu, L., Puebla, P., Caballero, E., González, M ... Curr. Med. Chem. 23 (11), 1100-1130, 2016 | 44 | 2016 |
| Synthesis and biological activity of naphthalene analogues of phenstatins: Naphthylphenstatins C Álvarez, R Alvarez, P Corchete, C Pérez-Melero, R Peláez, M Medarde Bioorganic & medicinal chemistry letters 17 (12), 3417-3420, 2007 | 39 | 2007 |
| Endozoochorous dispersal of aquatic plants: does seed gut passage affect plant performance? J Figuerola, L Santamaría, AJ Green, I Luque, R Alvarez, I Charalambidou American Journal of Botany 92 (4), 696-699, 2005 | 39 | 2005 |
| Spatial and temporal patterns in structure and diversity of Mediterranean forest of Quercus pyrenaica in relation to fire R Álvarez, A Munoz, XM Pesqueira, J Garcia-Duro, O Reyes, M Casal Forest Ecology and Management 257 (7), 1596-1602, 2009 | 38 | 2009 |
| Alkynyl Gold (I) complexes derived from 3-hydroxyflavones as multi-targeted drugs against colon cancer I Marmol, P Castellnou, R Alvarez, MC Gimeno, MJ Rodríguez-Yoldi, ... European journal of medicinal chemistry 183, 111661, 2019 | 36 | 2019 |
| Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins C Jimenez, Y Ellahioui, R Alvarez, L Aramburu, A Riesco, M González, ... European journal of medicinal chemistry 100, 210-222, 2015 | 36 | 2015 |
| New ligands of the tubulin colchicine site based on X-ray structures R Alvarez, M Medarde, R Pelaez Current topics in medicinal chemistry 14 (20), 2231-2252, 2014 | 34 | 2014 |
| Aortic thrombosis in a neonate with hereditary antithrombin III deficiency: successful outcome with thrombolytic and replacement treatment J Sanchez, F Velasco, R Alvarez, J Roman, A Torres Acta Pædiatrica 85 (2), 245-247, 1996 | 34 | 1996 |
| Influence of tree age on seed germination response to environmental factors and inhibitory substances in Pinus pinaster R Alvarez, L Valbuena, L Calvo International Journal of Wildland Fire 14 (3), 277-284, 2005 | 32 | 2005 |
| Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target A Vicente‐Blázquez, M González, R Álvarez, S Del Mazo, M Medarde, ... Medicinal research reviews 39 (3), 775-830, 2019 | 29 | 2019 |
| The masked polar group incorporation (MPGI) strategy in drug design: Effects of nitrogen substitutions on combretastatin and isocombretastatin tubulin inhibitors M González, Y Ellahioui, R Álvarez, L Gallego-Yerga, E Caballero, ... Molecules 24 (23), 4319, 2019 | 20 | 2019 |
| Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells R Álvarez, C Gajate, P Puebla, F Mollinedo, M Medarde, R Peláez European journal of medicinal chemistry 158, 167-183, 2018 | 20 | 2018 |
Rafael PeláezUniversity of SalamancaVerified email at usal.es
