| Allosteric modulation of G protein–coupled receptors LT May, K Leach, PM Sexton, A Christopoulos Annu. Rev. Pharmacol. Toxicol. 47, 1-51, 2007 | 791 | 2007 |
| Structure of the adenosine-bound human adenosine A1 receptor–Gi complex CJ Draper-Joyce, M Khoshouei, DM Thal, YL Liang, ATN Nguyen, ... Nature 558 (7711), 559-563, 2018 | 321 | 2018 |
| Structure of the adenosine A1 receptor reveals the basis for subtype selectivity A Glukhova, DM Thal, AT Nguyen, EA Vecchio, M Jörg, PJ Scammells, ... Cell 168 (5), 867-877. e13, 2017 | 276 | 2017 |
| The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans‐inhibition K Siddiquee, J Hampton, D McAnally, LT May, LH Smith British journal of pharmacology 168 (5), 1104-1117, 2013 | 169 | 2013 |
| A kinetic view of GPCR allostery and biased agonism JR Lane, LT May, RG Parton, PM Sexton, A Christopoulos Nature chemical biology 13 (9), 929-937, 2017 | 149 | 2017 |
| Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors LT May, VA Avlani, CJ Langmead, HJ Herdon, MD Wood, PM Sexton, ... Molecular pharmacology 72 (2), 463-476, 2007 | 130 | 2007 |
| Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs WH Bisson, AV Cheltsov, N Bruey-Sedano, B Lin, J Chen, N Goldberger, ... Proceedings of the National Academy of Sciences 104 (29), 11927-11932, 2007 | 128 | 2007 |
| Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist C Valant, LT May, L Aurelio, CH Chuo, PJ White, JA Baltos, PM Sexton, ... Proceedings of the National Academy of Sciences 111 (12), 4614-4619, 2014 | 116 | 2014 |
| Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice CX Qin, LT May, R Li, N Cao, S Rosli, M Deo, AE Alexander, D Horlock, ... Nature Communications 8 (1), 14232, 2017 | 110 | 2017 |
| Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands JG Baker, R Middleton, L Adams, LT May, SJ Briddon, B Kellam, SJ Hill British journal of pharmacology 159 (4), 772-786, 2010 | 107 | 2010 |
| Allosteric modulation of G protein-coupled receptors LT May, VA Avlani, PM Sexton, A Christopoulos Current pharmaceutical design 10 (17), 2003-2013, 2004 | 106 | 2004 |
| Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics LT May, LJ Bridge, LA Stoddart, SJ Briddon, SJ Hill The FASEB Journal 25 (10), 3465, 2011 | 104 | 2011 |
| Allosteric modulators of G-protein-coupled receptors LT May, A Christopoulos Current opinion in pharmacology 3 (5), 551-556, 2003 | 103 | 2003 |
| Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia CJ Draper-Joyce, R Bhola, J Wang, A Bhattarai, ATN Nguyen, ... Nature 597 (7877), 571-576, 2021 | 93 | 2021 |
| Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination YL Liang, P Zhao, C Draper-Joyce, JA Baltos, A Glukhova, TT Truong, ... ACS pharmacology & translational science 1 (1), 12-20, 2018 | 93 | 2018 |
| Allosteric modulation of endogenous metabolites as an avenue for drug discovery D Wootten, EE Savage, C Valant, LT May, KW Sloop, J Ficorilli, ... Molecular pharmacology 82 (2), 281-290, 2012 | 84 | 2012 |
| Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies SJ Hill, C Williams, LT May British journal of pharmacology 161 (6), 1266-1275, 2010 | 83 | 2010 |
| G-protein-coupled receptor allosterism: the promise and the problem (s) A Christopoulos, LT May, VA Avlani, PM Sexton Biochemical Society Transactions 32 (5), 873-877, 2004 | 82 | 2004 |
| Cardioprotective potential of annexin-A1 mimetics in myocardial infarction C Qin, YH Yang, L May, X Gao, AG Stewart, Y Tu, OL Woodman, ... Pharmacology & therapeutics 148, 47-65, 2015 | 78 | 2015 |
| Ligand-independent adenosine A2B receptor constitutive activity as a promoter of prostate cancer cell proliferation EA Vecchio, CYR Tan, KJ Gregory, A Christopoulos, PJ White, LT May Journal of Pharmacology and Experimental Therapeutics 357 (1), 36-44, 2016 | 74 | 2016 |
