MTOC translocation modulates IS formation and controls sustained T cell signaling NB Martin-Cofreces, J Robles-Valero, JR Cabrero, M Mittelbrunn, ... The Journal of cell biology 182 (5), 951-962, 2008 | 208 | 2008 |
Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity G Morlino, O Barreiro, F Baixauli, J Robles-Valero, JM González-Granado, ... Molecular and cellular biology 34 (8), 1412-1426, 2014 | 135 | 2014 |
Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas F Abate, AC da Silva-Almeida, S Zairis, J Robles-Valero, L Couronne, ... Proceedings of the National Academy of Sciences 114 (4), 764-769, 2017 | 121 | 2017 |
Endosomal clathrin drives actin accumulation at the immunological synapse C Calabia-Linares, J Robles-Valero, H de la Fuente, M Perez-Martinez, ... Journal of cell science 124 (5), 820-830, 2011 | 99 | 2011 |
A paradoxical tumor-suppressor role for the Rac1 exchange factor Vav1 in T cell acute lymphoblastic leukemia J Robles-Valero, LF Lorenzo-Martín, M Menacho-Marquez, ... Cancer Cell 32 (5), 608-623. e9, 2017 | 42 | 2017 |
Integrin and CD3/TCR activation are regulated by the scaffold protein AKAP450 J Robles-Valero, NB Martín-Cófreces, A Lamana, S Macdonald, Y Volkov, ... Blood, The Journal of the American Society of Hematology 115 (21), 4174-4184, 2010 | 35 | 2010 |
VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma LF Lorenzo-Martín, N Fernández-Parejo, M Menacho-Márquez, ... Nature Communications 11 (1), 4788, 2020 | 34 | 2020 |
Immunosuppression-independent role of regulatory T cells against hypertension-driven renal dysfunctions S Fabbiano, M Menacho-Márquez, J Robles-Valero, M Pericacho, ... Molecular and Cellular Biology 35 (20), 3528-3546, 2015 | 34 | 2015 |
Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms LF Lorenzo-Martín, C Citterio, M Menacho-Márquez, J Conde, RM Larive, ... Oncogene 38 (2), 209-227, 2019 | 18 | 2019 |
Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis J Robles‐Valero, L Fernández‐Nevado, LF Lorenzo‐Martín, M Cuadrado, ... The EMBO journal 40 (22), e108125, 2021 | 13 | 2021 |
Rho guanosine nucleotide exchange factors are not such bad guys after all in cancera J Robles-Valero, LF Lorenzo-Martín, I Fernández-Pisonero, XR Bustelo Small GTPases 11 (4), 233-239, 2020 | 11 | 2020 |
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors I Fernandez-Pisonero, L Clavaín, J Robles-Valero, LF Lorenzo-Martín, ... Cell Reports 38 (11), 2022 | 10 | 2022 |
Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor LF Lorenzo-Martín, S Rodriguez-Fdez, S Fabbiano, A Abad, ... Oncogene 39 (28), 5098-5111, 2020 | 10 | 2020 |
Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity N González, GA Cardama, P Chinestrad, J Robles-Valero, ... Frontiers in Cell and Developmental Biology 8, 240, 2020 | 10 | 2020 |
Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge G Ramírez‐Santiago, J Robles‐Valero, G Morlino, A Cruz‐Adalia, ... European journal of immunology 46 (10), 2376-2387, 2016 | 10 | 2016 |
VAV proteins as double agents in cancer: oncogenes with tumor suppressor roles M Cuadrado, J Robles-Valero Biology 10 (9), 888, 2021 | 7 | 2021 |
The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects V Ojeda, J Robles-Valero, M Barreira, XR Bustelo Molecular biology of the cell 26 (16), 2895-2912, 2015 | 7 | 2015 |
Characterization of the spectrum of trivalent VAV1‐mutation‐driven tumours using a gene‐edited mouse model J Robles‐Valero, L Fernández‐Nevado, M Cuadrado, LF Lorenzo‐Martín, ... Molecular Oncology 16 (19), 3533-3553, 2022 | 3 | 2022 |
An unexpected tumor suppressor role for VAV1a XR Bustelo, LF Lorenzo-Martín, M Cuadrado, I Fernández-Pisonero, ... Molecular & Cellular Oncology 5 (3), e1432257, 2018 | 2 | 2018 |
Distinct roles of vav family members in adaptive and innate immune models of arthritis J Conde, I Fernández-Pisonero, M Cuadrado, A Abad, J Robles-Valero, ... Biomedicines 9 (6), 695, 2021 | 1 | 2021 |