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Anuska Das
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The molecular basis for recognition of 5′-NNNCC-3′ PAM and its methylation state by Acidothermus cellulolyticus Cas9
A Das, TH Hand, CL Smith, E Wickline, M Zawrotny, H Li
Nature Communications 11 (1), 6346, 2020
162020
Structural principles of CRISPR-Cas enzymes used in nucleic acid detection
A Das, HN Goswami, CT Whyms, S Sridhara, H Li
Journal of structural biology 214 (1), 107838, 2022
122022
Directed evolution studies of a thermophilic Type II-C Cas9
TH Hand, A Das, H Li
Methods in enzymology 616, 265-288, 2019
122019
Molecular mechanism of active Cas7-11 in processing CRISPR RNA and interfering target RNA
HN Goswami, J Rai, A Das, H Li
Elife 11, e81678, 2022
112022
Phosphate Lock Residues of Acidothermus cellulolyticus Cas9 Are Critical to Its Substrate Specificity
TH Hand, A Das, MO Roth, CL Smith, UL Jean-Baptiste, H Li
ACS synthetic biology 7 (12), 2908-2917, 2018
82018
Coupled catalytic states and the role of metal coordination in Cas9
A Das, J Rai, MO Roth, Y Shu, ML Medina, MR Barakat, H Li
Nature catalysis 6 (10), 969-977, 2023
12023
Structural and Biochemical Analysis of a Methylation Sensitive Cas9
A Das
Biophysical Journal 120 (3), 17a, 2021
2021
Solvent Accessibility of CRISPR-CAS9 Target DNA is Correlated with Substrate Specificity
TH Hand, A Das, E Duboy, M Roth, C Smith, U Baptist, H Li
Biophysical Journal 114 (3), 252a, 2018
2018
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