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Taku Okazaki
Taku Okazaki
Verified email at iqb.u-tokyo.ac.jp
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Year
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
GJ Freeman, AJ Long, Y Iwai, K Bourque, T Chernova, H Nishimura, ...
The Journal of experimental medicine 192 (7), 1027-1034, 2000
62322000
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Y Latchman, CR Wood, T Chernova, D Chaudhary, M Borde, I Chernova, ...
Nature immunology 2 (3), 261-268, 2001
36572001
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
Y Iwai, M Ishida, Y Tanaka, T Okazaki, T Honjo, N Minato
Proceedings of the National Academy of Sciences 99 (19), 12293-12297, 2002
35842002
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
H Nishimura, T Okazaki, Y Tanaka, K Nakatani, M Hara, A Matsumori, ...
Science 291 (5502), 319-322, 2001
22712001
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
J Hamanishi, M Mandai, M Iwasaki, T Okazaki, Y Tanaka, K Yamaguchi, ...
Proceedings of the National Academy of Sciences 104 (9), 3360-3365, 2007
18472007
PD-1 and PD-1 ligands: from discovery to clinical application
T Okazaki, T Honjo
International immunology 19 (7), 813-824, 2007
16362007
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
T Okazaki, A Maeda, H Nishimura, T Kurosaki, T Honjo
Proceedings of the National Academy of Sciences 98 (24), 13866-13871, 2001
10842001
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
T Okazaki, S Chikuma, Y Iwai, S Fagarasan, T Honjo
Nature immunology 14 (12), 1212-1218, 2013
10082013
The PD-1–PD-L pathway in immunological tolerance
T Okazaki, T Honjo
Trends in immunology 27 (4), 195-201, 2006
9352006
Tumor cell expression of programmed cell death‐1 ligand 1 is a prognostic factor for malignant melanoma
R Hino, K Kabashima, YU Kato, H Yagi, M Nakamura, T Honjo, T Okazaki, ...
Cancer: Interdisciplinary International Journal of the American Cancer …, 2010
8442010
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice
T Okazaki, Y Tanaka, R Nishio, T Mitsuiye, A Mizoguchi, J Wang, M Ishida, ...
Nature medicine 9 (12), 1477-1483, 2003
7702003
Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue
H Masuzaki, Y Ogawa, N Isse, N Satoh, T Okazaki, M Shigemoto, K Mori, ...
Diabetes 44 (7), 855-858, 1995
6951995
Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4
HC Probst, K McCoy, T Okazaki, T Honjo, M van den Broek
Nature immunology 6 (3), 280-286, 2005
6772005
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
J Wang, T Yoshida, F Nakaki, H Hiai, T Okazaki, T Honjo
Proceedings of the National Academy of Sciences 102 (33), 11823-11828, 2005
5602005
PD-1 inhibits antiviral immunity at the effector phase in the liver
Y Iwai, S Terawaki, M Ikegawa, T Okazaki, T Honjo
Journal of Experimental Medicine 198 (1), 39-50, 2003
5472003
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
DY Lin, Y Tanaka, M Iwasaki, AG Gittis, HP Su, B Mikami, T Okazaki, ...
Proceedings of the National Academy of Sciences 105 (8), 3011-3016, 2008
5242008
Role of PD-1 in regulating T-cell immunity
HT Jin, R Ahmed, T Okazaki
Negative co-receptors and ligands, 17-37, 2011
4132011
Structural organization and chromosomal assignment of the human obese gene
N Isse, Y Ogawa, N Tamura, H Masuzaki, K Mori, T Okazaki, N Satoh, ...
Journal of Biological Chemistry 270 (46), 27728-27733, 1995
4091995
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues
M Ishida, Y Iwai, Y Tanaka, T Okazaki, GJ Freeman, N Minato, T Honjo
Immunology letters 84 (1), 57-62, 2002
3852002
IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity
S Terawaki, S Chikuma, S Shibayama, T Hayashi, T Yoshida, T Okazaki, ...
The Journal of Immunology 186 (5), 2772-2779, 2011
3782011
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