| SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein H Higashi, R Tsutsumi, S Muto, T Sugiyama, T Azuma, M Asaka, ... Science 295 (5555), 683-686, 2002 | 1285 | 2002 |
| Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites H Higashi, R Tsutsumi, A Fujita, S Yamazaki, M Asaka, T Azuma, ... Proceedings of the National Academy of Sciences 99 (22), 14428-14433, 2002 | 747 | 2002 |
| Attenuation of Helicobacter pylori CagA· SHP-2 signaling by interaction between CagA and C-terminal Src kinase R Tsutsumi, H Higashi, M Higuchi, M Okada, M Hatakeyama Journal of Biological Chemistry 278 (6), 3664-3670, 2003 | 374 | 2003 |
| Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation H Higashi, A Nakaya, R Tsutsumi, K Yokoyama, Y Fujii, S Ishikawa, ... Journal of Biological Chemistry 279 (17), 17205-17216, 2004 | 355 | 2004 |
| Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA R Tsutsumi, A Takahashi, T Azuma, H Higashi, M Hatakeyama Molecular and cellular biology, 2006 | 272 | 2006 |
| Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA M Naito, T Yamazaki, R Tsutsumi, H Higashi, K Onoe, S Yamazaki, ... Gastroenterology 130 (4), 1181-1190, 2006 | 263 | 2006 |
| Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95 J Noritake, Y Fukata, T Iwanaga, N Hosomi, R Tsutsumi, N Matsuda, ... Journal of cell biology 186 (1), 147-160, 2009 | 244 | 2009 |
| Identification of G protein α subunit-palmitoylating enzyme R Tsutsumi, Y Fukata, J Noritake, T Iwanaga, F Perez, M Fukata Molecular and cellular biology 29 (2), 435-447, 2009 | 140 | 2009 |
| SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver A Takahashi, R Tsutsumi, I Kikuchi, C Obuse, Y Saito, A Seidi, R Karisch, ... Molecular cell 43 (1), 45-56, 2011 | 135 | 2011 |
| Dynamic protein palmitoylation in cellular signaling T Iwanaga, R Tsutsumi, J Noritake, Y Fukata, M Fukata Progress in lipid research 48 (3-4), 117-127, 2009 | 135 | 2009 |
| Discovery of protein-palmitoylating enzymes R Tsutsumi, Y Fukata, M Fukata Pflügers Archiv-European Journal of Physiology 456, 1199-1206, 2008 | 120 | 2008 |
| YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function R Tsutsumi, M Masoudi, A Takahashi, Y Fujii, T Hayashi, I Kikuchi, ... Developmental cell 26 (6), 658-665, 2013 | 102 | 2013 |
| Palmitoylation regulates epidermal homeostasis and hair follicle differentiation P Mill, AWS Lee, Y Fukata, R Tsutsumi, M Fukata, M Keighren, RM Porter, ... PLoS genetics 5 (11), e1000748, 2009 | 97 | 2009 |
| Sticking it to cancer with molecular glue for SHP2 H Ran, R Tsutsumi, T Araki, BG Neel Cancer cell 30 (2), 194-196, 2016 | 85 | 2016 |
| Conditional gene silencing utilizing the lac repressor reveals a role of SHP‐2 in cagA‐positive Helicobacter pylori pathogenicity M Higuchi, R Tsutsumi, H Higashi, M Hatakeyama Cancer science 95 (5), 442-447, 2004 | 85 | 2004 |
| Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis HA Hamid, A Tanaka, T Ida, A Nishimura, T Matsunaga, S Fujii, M Morita, ... Redox biology 21, 101096, 2019 | 68 | 2019 |
| Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity A Shmueli, M Segal, T Sapir, R Tsutsumi, J Noritake, A Bar, S Sapoznik, ... The EMBO journal 29 (1), 107-119, 2010 | 62 | 2010 |
| Off‐target inhibition by active site‐targeting SHP 2 inhibitors R Tsutsumi, H Ran, BG Neel FEBS open bio 8 (9), 1405-1411, 2018 | 51 | 2018 |
| Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2 R Tsutsumi, J Harizanova, R Stockert, K Schröder, PIH Bastiaens, ... Nature communications 8 (1), 466, 2017 | 48 | 2017 |
| Selenoprotein P; P for plasma, prognosis, prophylaxis, and more R Tsutsumi, Y Saito Biological and Pharmaceutical Bulletin 43 (3), 366-374, 2020 | 27 | 2020 |
