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Arohan Subramanya
Arohan Subramanya
Associate Professor of Medicine and of Cell Biology, University of Pittsburgh School of Medicine
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Year
Whole-genome association study identifies STK39 as a hypertension susceptibility gene
Y Wang, JR O'Connell, PF McArdle, JB Wade, SE Dorff, SJ Shah, X Shi, ...
Proceedings of the National Academy of Sciences 106 (1), 226-231, 2009
3522009
Distal convoluted tubule
AR Subramanya, DH Ellison
Clinical Journal of the American Society of Nephrology 9 (12), 2147-2163, 2014
2992014
Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport
CL Yang, X Zhu, Z Wang, AR Subramanya, DH Ellison
The Journal of clinical investigation 115 (5), 1379-1387, 2005
2132005
Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway
DJ Rozansky, T Cornwall, AR Subramanya, S Rogers, YF Yang, LL David, ...
The Journal of clinical investigation 119 (9), 2601-2612, 2009
1702009
WNK1 kinase isoform switch regulates renal potassium excretion
JB Wade, L Fang, J Liu, D Li, CL Yang, AR Subramanya, D Maouyo, ...
Proceedings of the National Academy of Sciences 103 (22), 8558-8563, 2006
1452006
WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction
AR Subramanya, J Liu, DH Ellison, JB Wade, PA Welling
Journal of biological chemistry 284 (27), 18471-18480, 2009
1362009
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
AR Subramanya, CL Yang, X Zhu, DH Ellison
American Journal of Physiology-Renal Physiology 290 (3), F619-F624, 2006
1352006
WNK kinases influence TRPV4 channel function and localization
Y Fu, A Subramanya, D Rozansky, DM Cohen
American Journal of Physiology-Renal Physiology 290 (6), F1305-F1314, 2006
1092006
WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron
AR Subramanya, CL Yang, JA McCormick, DH Ellison
Kidney international 70 (4), 630-634, 2006
1032006
Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action
A Roy, L Al-Qusairi, BF Donnelly, C Ronzaud, AL Marciszyn, F Gong, ...
The Journal of clinical investigation 125 (9), 3433-3448, 2015
692015
WNK kinases sense molecular crowding and rescue cell volume via phase separation
CR Boyd-Shiwarski, DJ Shiwarski, SE Griffiths, RT Beacham, L Norrell, ...
Cell 185 (24), 4488-4506. e20, 2022
662022
Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis
BF Donnelly, PG Needham, AC Snyder, A Roy, S Khadem, JL Brodsky, ...
Journal of Biological Chemistry 288 (18), 13124-13135, 2013
632013
Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent
CR Boyd-Shiwarski, DJ Shiwarski, A Roy, HN Namboodiri, LJ Nkashama, ...
Molecular biology of the cell 29 (4), 499-509, 2018
622018
Endothelial-derived vasoactive mediators in polycystic kidney disease
MA Al-Nimri, R Komers, TT Oyama, AR Subramanya, JN Lindsley, ...
Kidney international 63 (5), 1776-1784, 2003
622003
The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel
TM Buck, L Plavchak, A Roy, BF Donnelly, OB Kashlan, TR Kleyman, ...
Journal of Biological Chemistry 288 (25), 18366-18380, 2013
602013
The thiazide-sensitive NaCl cotransporter is targeted for chaperone-dependent endoplasmic reticulum-associated degradation
PG Needham, K Mikoluk, P Dhakarwal, S Khadem, AC Snyder, ...
Journal of Biological Chemistry 286 (51), 43611-43621, 2011
562011
Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing
A Roy, JH Goodman, G Begum, BF Donnelly, G Pittman, EJ Weinman, ...
American Journal of Physiology-Renal Physiology 308 (4), F366-F376, 2015
502015
Endoplasmic reticulum–associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome
BM O'Donnell, TD Mackie, AR Subramanya, JL Brodsky
Journal of Biological Chemistry 292 (31), 12813-12827, 2017
412017
Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC
L Al-Qusairi, D Basquin, A Roy, M Stifanelli, RD Rajaram, A Debonneville, ...
American Journal of Physiology-Renal Physiology 311 (2), F330-F342, 2016
382016
Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase
Z Wang, AR Subramanya, LM Satlin, NM Pastor-Soler, MD Carattino, ...
American Journal of Physiology-Cell Physiology 305 (8), C846-C853, 2013
382013
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