| X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability AT Gres, KA Kirby, VN KewalRamani, JJ Tanner, O Pornillos, ... Science 349 (6243), 99-103, 2015 | 257 | 2015 |
| Mechanism of inhibition of HIV-1 reverse transcriptase by 4′-ethynyl-2-fluoro-2′-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor E Michailidis, B Marchand, EN Kodama, K Singh, M Matsuoka, KA Kirby, ... Journal of biological chemistry 284 (51), 35681-35691, 2009 | 152 | 2009 |
| Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1, 3-diones: dual inhibition against HIV reverse … SKV Vernekar, Z Liu, E Nagy, L Miller, KA Kirby, DJ Wilson, J Kankanala, ... Journal of medicinal chemistry 58 (2), 651-664, 2015 | 133 | 2015 |
| Structural aspects of drug resistance and inhibition of HIV-1 reverse transcriptase K Singh, B Marchand, KA Kirby, E Michailidis, SG Sarafianos Viruses 2 (2), 606-638, 2010 | 101 | 2010 |
| 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms E Michailidis, AD Huber, EM Ryan, YT Ong, MD Leslie, KB Matzek, ... Journal of Biological Chemistry 289 (35), 24533-24548, 2014 | 100 | 2014 |
| Baicalein and baicalin inhibit SARS-CoV-2 RNA-dependent-RNA polymerase K Zandi, K Musall, A Oo, D Cao, B Liang, P Hassandarvish, S Lan, ... Microorganisms 9 (5), 893, 2021 | 91 | 2021 |
| Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) ZL Salie, KA Kirby, E Michailidis, B Marchand, K Singh, LC Rohan, ... Proceedings of the National Academy of Sciences 113 (33), 9274-9279, 2016 | 85 | 2016 |
| Antiviral therapies: focus on hepatitis B reverse transcriptase E Michailidis, KA Kirby, A Hachiya, W Yoo, SP Hong, SO Kim, WR Folk, ... The international journal of biochemistry & cell biology 44 (7), 1060-1071, 2012 | 72 | 2012 |
| Design, synthesis, and biological evaluations of hydroxypyridonecarboxylic acids as inhibitors of HIV reverse transcriptase associated RNase H J Kankanala, KA Kirby, F Liu, L Miller, E Nagy, DJ Wilson, MA Parniak, ... Journal of medicinal chemistry 59 (10), 5051-5062, 2016 | 63 | 2016 |
| Avoiding drug resistance in HIV reverse transcriptase ME Cilento, KA Kirby, SG Sarafianos Chemical reviews 121 (6), 3271-3296, 2021 | 59 | 2021 |
| Comparison of porous and nonporous materials for methane storage PK Thallapally, KA Kirby, JL Atwood New Journal of Chemistry 31 (5), 628-630, 2007 | 57 | 2007 |
| The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine MM Schuckmann, B Marchand, A Hachiya, EN Kodama, KA Kirby, ... Journal of biological chemistry 285 (49), 38700-38709, 2010 | 52 | 2010 |
| Small molecule inhibitor that stabilizes the autoinhibited conformation of the oncogenic tyrosine phosphatase SHP2 X Wu, G Xu, X Li, W Xu, Q Li, W Liu, KA Kirby, ML Loh, J Li, SG Sarafianos, ... Journal of medicinal chemistry 62 (3), 1125-1137, 2018 | 51 | 2018 |
| Effects of substitutions at the 4′ and 2 positions on the bioactivity of 4′-ethynyl-2-fluoro-2′-deoxyadenosine KA Kirby, E Michailidis, TL Fetterly, MA Steinbach, K Singh, B Marchand, ... Antimicrobial agents and chemotherapy 57 (12), 6254-6264, 2013 | 47 | 2013 |
| 3-Hydroxypyrimidine-2, 4-diones as selective active site inhibitors of HIV reverse transcriptase-associated RNase H: design, synthesis, and biochemical evaluations J Tang, F Liu, E Nagy, L Miller, KA Kirby, DJ Wilson, B Wu, SG Sarafianos, ... Journal of medicinal chemistry 59 (6), 2648-2659, 2016 | 45 | 2016 |
| K70Q adds high-level tenofovir resistance to “Q151M complex” HIV reverse transcriptase through the enhanced discrimination mechanism A Hachiya, EN Kodama, MM Schuckmann, KA Kirby, E Michailidis, ... PloS one 6 (1), e16242, 2011 | 45 | 2011 |
| Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA E Michailidis, EM Ryan, A Hachiya, KA Kirby, B Marchand, MD Leslie, ... Retrovirology 10, 1-12, 2013 | 44 | 2013 |
| Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2, 4-diones as inhibitors of HIV reverse transcriptase-associated RNase H J Kankanala, KA Kirby, AD Huber, MC Casey, DJ Wilson, SG Sarafianos, ... European journal of medicinal chemistry 141, 149-161, 2017 | 43 | 2017 |
| Double-winged 3-hydroxypyrimidine-2, 4-diones: potent and selective inhibition against HIV-1 RNase H with significant antiviral activity SKV Vernekar, J Tang, B Wu, AD Huber, MC Casey, N Myshakina, ... Journal of medicinal chemistry 60 (12), 5045-5056, 2017 | 43 | 2017 |
| Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors K Singh, JA Flores, KA Kirby, U Neogi, A Sonnerborg, A Hachiya, K Das, ... Viruses 6 (9), 3535-3562, 2014 | 41 | 2014 |
Stefan G. SarafianosNahmias Schinazi Distinguished Research Chair, Professor, LOBP-Pediatrics, Emory Univ. SOMVerified email at emory.edu
