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Brett E. Houk, Ph.D.
Brett E. Houk, Ph.D.
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Title
Cited by
Cited by
Year
The clinical KRAS (G12C) inhibitor AMG 510 drives anti-tumour immunity
J Canon, K Rex, AY Saiki, C Mohr, K Cooke, D Bagal, K Gaida, T Holt, ...
Nature 575 (7781), 217-223, 2019
16942019
KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors
DS Hong, MG Fakih, JH Strickler, J Desai, GA Durm, GI Shapiro, ...
New England Journal of Medicine 383 (13), 1207-1217, 2020
12842020
Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis
BE Houk, CL Bello, B Poland, LS Rosen, GD Demetri, RJ Motzer
Cancer chemotherapy and pharmacology 66, 357-371, 2010
5542010
A population pharmacokinetic meta-analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients
BE Houk, CL Bello, D Kang, M Amantea
Clinical Cancer Research 15 (7), 2497-2506, 2009
2752009
A phase II study of sunitinib in Japanese patients with metastatic renal cell carcinoma: insights into the treatment, efficacy and safety
H Uemura, N Shinohara, T Yuasa, Y Tomita, H Fujimoto, M Niwakawa, ...
Japanese journal of clinical oncology 40 (3), 194-202, 2010
1682010
A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas
A Rajan, RJ Kelly, JB Trepel, YS Kim, SV Alarcon, S Kummar, M Gutierrez, ...
Clinical Cancer Research 17 (21), 6831-6839, 2011
1452011
A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors
SF Jones, LL Siu, JC Bendell, JM Cleary, ARA Razak, JR Infante, ...
Investigational new drugs 33, 1100-1107, 2015
1292015
Overall survival and updated results from a phase II study of sunitinib in Japanese patients with metastatic renal cell carcinoma
Y Tomita, N Shinohara, T Yuasa, H Fujimoto, M Niwakawa, S Mugiya, ...
Japanese journal of clinical oncology 40 (12), 1166-1172, 2010
1282010
Kinetic modeling of plasmid DNA degradation in rat plasma
BE Houk, G Hochhaus, JA Hughes
AAPS PharmSci 1, 15-20, 1999
1191999
First-in-human study of PF-05212384 (PKI-587), a small-molecule, intravenous, dual inhibitor of PI3K and mTOR in patients with advanced cancer
GI Shapiro, KM Bell-McGuinn, JR Molina, J Bendell, J Spicer, EL Kwak, ...
Clinical Cancer Research 21 (8), 1888-1895, 2015
1182015
Exposure-response of sunitinib in metastatic renal cell carcinoma (mRCC): A population pharmacokinetic/pharmacodynamic (PKPD) approach
BE Houk, CL Bello, MD Michaelson, RM Bukowski, BG Redman, ...
Journal of Clinical Oncology 25 (18_suppl), 5027-5027, 2007
842007
A randomized phase II non-comparative study of PF-04691502 and gedatolisib (PF-05212384) in patients with recurrent endometrial cancer
JM Del Campo, M Birrer, C Davis, K Fujiwara, A Gollerkeri, M Gore, ...
Gynecologic oncology 142 (1), 62-69, 2016
832016
Phase I study of PF-04691502, a small-molecule, oral, dual inhibitor of PI3K and mTOR, in patients with advanced cancer
CD Britten, AA Adjei, R Millham, BE Houk, G Borzillo, K Pierce, ...
Investigational new drugs 32, 510-517, 2014
812014
A multi-arm phase I study of the PI3K/mTOR inhibitors PF-04691502 and gedatolisib (PF-05212384) plus irinotecan or the MEK inhibitor PD-0325901 in advanced cancer
ZA Wainberg, M Alsina, HP Soares, I Braña, CD Britten, G Del Conte, ...
Targeted oncology 12, 775-785, 2017
802017
Pharmacokinetics of plasmid DNA in the rat
BE Houk, R Martin, G Hochhaus, JA Hughes
Pharmaceutical research 18, 67-74, 2001
712001
PKPD modeling of VEGF, sVEGFR‐2, sVEGFR‐3, and sKIT as predictors of tumor dynamics and overall survival following sunitinib treatment in GIST
EK Hansson, MA Amantea, P Westwood, PA Milligan, BE Houk, J French, ...
CPT: pharmacometrics & systems pharmacology 2 (11), 1-9, 2013
682013
Phase I trial of the HSP90 inhibitor PF-04929113 (SNX5422) in adult patients with recurrent, refractory hematologic malignancies
N Reddy, PM Voorhees, BE Houk, N Brega, JM Hinson Jr, A Jillela
Clinical Lymphoma Myeloma and Leukemia 13 (4), 385-391, 2013
452013
Effect of rifampin on the pharmacokinetics of SU11248 in healthy volunteers
C Bello, B Houk, L Sherman, S Misbah, N Sarapa, J Smeraglia, X Haung
Journal of Clinical Oncology 23 (16_suppl), 3078-3078, 2005
302005
Standard error of empirical Bayes estimate in NONMEM® VI
D Kang, KS Bae, BE Houk, RM Savic, MO Karlsson
The Korean journal of physiology & pharmacology: official journal of the …, 2012
272012
Discovery of 2, 4-bis-arylamino-1, 3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors
JL Buchanan, JR Newcomb, DP Carney, SC Chaffee, L Chai, R Cupples, ...
Bioorganic & medicinal chemistry letters 21 (8), 2394-2399, 2011
272011
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