| Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML CD DiNardo, IS Tiong, A Quaglieri, S MacRaild, S Loghavi, FC Brown, ... Blood 135 (11), 791-803, 2020 | 466 | 2020 |
| DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia DC Johnson, CY Taabazuing, MC Okondo, AJ Chui, SD Rao, FC Brown, ... Nature medicine 24 (8), 1151-1156, 2018 | 286 | 2018 |
| Chemotherapy and venetoclax in elderly acute myeloid leukemia trial (CAVEAT): a phase Ib dose-escalation study of venetoclax combined with modified intensive chemotherapy CC Chua, AW Roberts, J Reynolds, CY Fong, SB Ting, JM Salmon, ... Journal of Clinical Oncology 38 (30), 3506-3517, 2020 | 134 | 2020 |
| Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias R Thijssen, ST Diepstraten, D Moujalled, E Chew, C Flensburg, MX Shi, ... Blood, The Journal of the American Society of Hematology 137 (20), 2721-2735, 2021 | 86 | 2021 |
| Peptidomimetic blockade of MYB in acute myeloid leukemia K Ramaswamy, L Forbes, G Minuesa, T Gindin, F Brown, MG Kharas, ... Nature Communications 9 (1), 110, 2018 | 82 | 2018 |
| Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling CS Tremblay, FC Brown, M Collett, J Saw, SK Chiu, SE Sonderegger, ... Leukemia 30 (10), 1993-2001, 2016 | 64 | 2016 |
| MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia FC Brown, E Still, RP Koche, CY Yim, S Takao, P Cifani, C Reed, ... Cancer discovery 8 (4), 478-497, 2018 | 62 | 2018 |
| Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia FC Brown, P Cifani, E Drill, J He, E Still, S Zhong, S Balasubramanian, ... British journal of haematology 176 (1), 86-91, 2017 | 38 | 2017 |
| Bcl-2 family protein Bok is a regulator of uridine metabolism in mammals Proc Natl Acad Sci U S A 116 (31), 15469-15474, 2019 | 36* | 2019 |
| Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia DM Moujalled, FC Brown, CC Chua, MA Dengler, G Pomilio, NS Anstee, ... Blood, The Journal of the American Society of Hematology 141 (6), 634-644, 2023 | 27 | 2023 |
| Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model FC Brown, AJ Conway, L Cerruti, JE Collinge, C McLean, JS Wiley, ... Blood 126 (26), 2863-2870, 2015 | 27 | 2015 |
| Pharmacologic reduction of mitochondrial iron triggers a noncanonical BAX/BAK-dependent cell death S Garciaz, AA Guirguis, S Müller, FC Brown, YC Chan, A Motazedian, ... Cancer Discovery 12 (3), 774-791, 2022 | 20 | 2022 |
| Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency AJ Conway, FC Brown, EJ Hortle, G Burgio, SJ Foote, CJ Morton, ... Disease Models & Mechanisms 11 (5), dmm034678, 2018 | 18 | 2018 |
| ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level FC Brown, N Scott, G Rank, JE Collinge, J Vadolas, N Vickaryous, ... Blood Cells, Molecules, and Diseases 50 (2), 86-92, 2013 | 17 | 2013 |
| Acquired mutations in BAX confer resistance to BH3 mimetics in acute myeloid leukemia DM Moujalled, FC Brown, G Pomilio, NS Anstee, V Litalien, ER Thompson, ... Blood 136, 7-8, 2020 | 13 | 2020 |
| A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen AJ Conway, FC Brown, RO Fullinfaw, BT Kile, SM Jane, DJ Curtis Disease models & mechanisms 10 (8), 1005-1013, 2017 | 12 | 2017 |
| Induction of human fetal hemoglobin expression by adenosine-2’, 3’-dialdehyde Y He, G Rank, M Zhang, J Ju, R Liu, Z Xu, F Brown, L Cerruti, C Ma, R Tan, ... Journal of translational medicine 11 (1), 1-7, 2013 | 12 | 2013 |
| Loss of Dynamin 2 GTPase function results in microcytic anaemia FC Brown, M Collett, CS Tremblay, G Rank, P De Camilli, CJ Booth, ... British journal of haematology 178 (4), 616-628, 2017 | 10 | 2017 |
| Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia J So, AC Lewis, LK Smith, K Stanley, R Franich, D Yoannidis, L Pijpers, ... EMBO Molecular Medicine 14 (7), e15203, 2022 | 9 | 2022 |
| Characterization of Tfrc-mutant mice with microcytic phenotypes AJ Conway, FC Brown, G Rank, BT Kile, CJ Morton, SM Jane, DJ Curtis Blood advances 2 (15), 1914-1922, 2018 | 9 | 2018 |
