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Donald Gagné
Donald Gagné
Health Canada
Adresse e-mail validée de canada.ca
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A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis
JM Burton, S Kimball, R Vieth, A Bar-Or, HM Dosch, R Cheung, D Gagne, ...
Neurology 74 (23), 1852-1859, 2010
4742010
A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis
JM Burton, S Kimball, R Vieth, A Bar-Or, HM Dosch, R Cheung, D Gagne, ...
Neurology 74 (23), 1852-1859, 2010
4722010
Widespread tissue distribution of steroid sulfatase, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4isomerase (3β-HSD), 17β-HSD5α-reductase and aromatase activities in the rhesus monkey
C Martel, MH Meiner, D Gagné, J Simarda, F Labrie
Molecular and cellular endocrinology 104 (1), 103-111, 1994
2541994
Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis
KA McLaughlin, T Chitnis, J Newcombe, B Franz, J Kennedy, S McArdel, ...
The Journal of Immunology 183 (6), 4067-4076, 2009
2192009
Cholecalciferol plus calcium suppresses abnormal PBMC reactivity in patients with multiple sclerosis
S Kimball, R Vieth, HM Dosch, A Bar-Or, R Cheung, D Gagne, P O'Connor, ...
The Journal of Clinical Endocrinology & Metabolism 96 (9), 2826-2834, 2011
1062011
Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis
KC O'Connor, C Lopez-Amaya, D Gagne, L Lovato, NH Moore-Odom, ...
Journal of neuroimmunology 223 (1-2), 92-99, 2010
682010
Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells
AA Grosset, M Labrie, D Gagné, MC Vladoiu, L Gaboury, N Doucet, ...
BMC cancer 14, 1-10, 2014
592014
Elevated serum inflammatory markers in post-poliomyelitis syndrome
CB Fordyce, D Gagne, F Jalili, S Alatab, DL Arnold, D Da Costa, ...
Journal of the neurological sciences 271 (1-2), 80-86, 2008
502008
Conservation of flexible residue clusters among structural and functional enzyme homologues
D Gagné, LA Charest, S Morin, EL Kovrigin, N Doucet
Journal Of Biological Chemistry 287 (53), 44289-44300, 2012
462012
Conservation of dynamics associated with biological function in an enzyme superfamily
C Narayanan, DN Bernard, K Bafna, D Gagné, CS Chennubhotla, ...
Structure 26 (3), 426-436. e3, 2018
422018
Structural and functional importance of local and global conformational fluctuations in the RN ase A superfamily
D Gagné, N Doucet
The FEBS journal 280 (22), 5596-5607, 2013
422013
Perturbation of the conformational dynamics of an active-site loop alters enzyme activity
D Gagné, RL French, C Narayanan, M Simonović, PK Agarwal, N Doucet
Structure 23 (12), 2256-2266, 2015
412015
Rapid modulation of ovarian 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene expression by prolactin and human chorionic gonadotropin in the hypophysectomized rat
C Martel, D Gagné, J Couet, Y Labrie, J Simard, F Labrie
Molecular and cellular endocrinology 99 (1), 63-71, 1994
391994
Maintenance of native-like protein dynamics may not be required for engineering functional proteins
SMC Gobeil, CM Clouthier, J Park, D Gagné, AM Berghuis, N Doucet, ...
Chemistry & biology 21 (10), 1330-1340, 2014
372014
Design of a peptidic inhibitor that targets the dimer interface of a prototypic galectin
MC Vladoiu, M Labrie, M Létourneau, P Egesborg, D Gagné, É Billard, ...
Oncotarget 6 (38), 40970, 2015
252015
Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily
C Narayanan, D Gagné, KA Reynolds, N Doucet
Scientific reports 7 (1), 3207, 2017
242017
Ligand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividans
D Gagné, C Narayanan, N Nguyen-Thi, LD Roux, DN Bernard, ...
Biochemistry 55 (30), 4184-4196, 2016
232016
The structural dynamics of engineered β-lactamases vary broadly on three timescales yet sustain native function
SMC Gobeil, MC Ebert, J Park, D Gagné, N Doucet, AM Berghuis, J Pleiss, ...
Scientific Reports 9 (1), 6656, 2019
222019
Mitochondrial DNA haplogroups and mutations in children with acquired central demyelination
S Venkateswaran, K Zheng, M Sacchetti, D Gagne, DL Arnold, ...
Neurology 76 (9), 774-780, 2011
212011
Ligand-induced variations in structural and dynamical properties within an enzyme superfamily
C Narayanan, DN Bernard, K Bafna, D Gagné, PK Agarwal, N Doucet
Frontiers in Molecular Biosciences 5, 54, 2018
202018
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