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Michael Milone
Michael Milone
Associate Professor of Pathology & Laboratory Medicine, university of pennsylvania
Verified email at mail.med.upenn.edu
Title
Cited by
Cited by
Year
Chimeric antigen receptor–modified T cells for acute lymphoid leukemia
SA Grupp, M Kalos, D Barrett, R Aplenc, DL Porter, SR Rheingold, ...
New England Journal of Medicine 368 (16), 1509-1518, 2013
40082013
CAR T cell immunotherapy for human cancer
CH June, RS O’Connor, OU Kawalekar, S Ghassemi, MC Milone
Science 359 (6382), 1361-1365, 2018
23642018
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
DL Porter, WT Hwang, NV Frey, SF Lacey, PA Shaw, AW Loren, A Bagg, ...
Science translational medicine 7 (303), 303ra139-303ra139, 2015
17882015
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo
MC Milone, JD Fish, C Carpenito, RG Carroll, GK Binder, D Teachey, ...
Molecular therapy 17 (8), 1453-1464, 2009
13652009
Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells
OU Kawalekar, RS O’Connor, JA Fraietta, L Guo, SE McGettigan, ...
Immunity 44 (2), 380-390, 2016
10582016
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
C Carpenito, MC Milone, R Hassan, JC Simonet, M Lakhal, MM Suhoski, ...
Proceedings of the National Academy of Sciences 106 (9), 3360-3365, 2009
10102009
Clinical use of lentiviral vectors
MC Milone, U O’Doherty
Leukemia 32 (7), 1529-1541, 2018
7552018
B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma
AD Cohen, AL Garfall, EA Stadtmauer, JJ Melenhorst, SF Lacey, ...
The Journal of clinical investigation 129 (6), 2210-2221, 2019
6202019
Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease
CT Ellebrecht, VG Bhoj, A Nace, EJ Choi, X Mao, MJ Cho, G Di Zenzo, ...
Science 353 (6295), 179-184, 2016
5602016
An introduction to chimeric antigen receptor (CAR) T‐cell immunotherapy for human cancer
S Feins, W Kong, EF Williams, MC Milone, JA Fraietta
American journal of hematology 94 (S1), S3-S9, 2019
4662019
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
Y Xiang, ZE Stine, J Xia, Y Lu, RS O’Connor, BJ Altman, AL Hsieh, ...
The Journal of clinical investigation 125 (6), 2293-2306, 2015
4422015
Use of chimeric antigen receptor-modified T-cells to treat cancer
CH June, BL Levine, DL Porter, MD Kalos, MC Milone
US Patent 9,499,629, 2016
4362016
Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor–transduced human T cells in solid tumors
EK Moon, LC Wang, DV Dolfi, CB Wilson, R Ranganathan, J Sun, ...
Clinical cancer research 20 (16), 4262-4273, 2014
4252014
Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules
MM Suhoski, TN Golovina, NA Aqui, VC Tai, A Varela-Rohena, ...
Molecular Therapy 15 (5), 981-988, 2007
3132007
Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells
MJ Frigault, J Lee, MC Basil, C Carpenito, S Motohashi, J Scholler, ...
Cancer immunology research 3 (4), 356-367, 2015
3072015
Substrate rigidity regulates human T cell activation and proliferation
RS O’Connor, X Hao, K Shen, K Bashour, T Akimova, WW Hancock, ...
The Journal of Immunology 189 (3), 1330-1339, 2012
2982012
Methods for treatment of cancer
CH June, BL Levine, DL Porter, MD Kalos, MC Milone
US Patent 8,906,682, 2014
2712014
Compositions for treatment of cancer
CH June, BL Levine, DL Porter, MD Kalos, MC Milone
US Patent 8,911,993, 2014
2692014
High-affinity GD2-specific CAR T cells induce fatal encephalitis in a preclinical neuroblastoma model
SA Richman, S Nunez-Cruz, B Moghimi, LZ Li, ZT Gershenson, ...
Cancer immunology research 6 (1), 36-46, 2018
2472018
F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation
A Babich, S Li, RS O'Connor, MC Milone, BD Freedman, JK Burkhardt
Journal of Cell Biology 197 (6), 775-787, 2012
2342012
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