A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo Y Liu, Y Cao, W Zhang, S Bergmeier, Y Qian, H Akbar, R Colvin, J Ding, ... Molecular cancer therapeutics 11 (8), 1672-1682, 2012 | 578 | 2012 |
MERTK receptor tyrosine kinase is a therapeutic target in melanoma J Schlegel, MJ Sambade, S Sather, SJ Moschos, AC Tan, A Winges, ... The Journal of clinical investigation 123 (5), 2257-2267, 2013 | 152 | 2013 |
UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor W Zhang, D DeRyckere, D Hunter, J Liu, MA Stashko, KA Minson, ... Journal of medicinal chemistry 57 (16), 7031-7041, 2014 | 146 | 2014 |
Small compound inhibitors of basal glucose transport inhibit cell proliferation and induce apoptosis in cancer cells via glucose-deprivation-like mechanisms Y Liu, W Zhang, Y Cao, Y Liu, S Bergmeier, X Chen Cancer letters 298 (2), 176-185, 2010 | 92 | 2010 |
UNC1062, a new and potent Mer inhibitor J Liu, W Zhang, MA Stashko, D DeRyckere, CT Cummings, D Hunter, ... European journal of medicinal chemistry 65, 83-93, 2013 | 84 | 2013 |
Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors W Zhang, D Zhang, MA Stashko, D DeRyckere, D Hunter, D Kireev, ... Journal of medicinal chemistry 56 (23), 9683-9692, 2013 | 81 | 2013 |
Novel inhibitors of basal glucose transport as potential anticancer agents W Zhang, Y Liu, X Chen, SC Bergmeier Bioorganic & medicinal chemistry letters 20 (7), 2191-2194, 2010 | 76 | 2010 |
Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis W Zhang, AL McIver, MA Stashko, D DeRyckere, BR Branchford, D Hunter, ... Journal of medicinal chemistry 56 (23), 9693-9700, 2013 | 67 | 2013 |
UNC2025, a MERTK small-molecule inhibitor, is therapeutically effective alone and in combination with methotrexate in leukemia models D DeRyckere, AB Lee-Sherick, MG Huey, AA Hill, JW Tyner, ... Clinical Cancer Research 23 (6), 1481-1492, 2017 | 66 | 2017 |
Small molecule inhibition of MERTK is efficacious in non–small cell lung cancer models independent of driver oncogene status CT Cummings, W Zhang, KD Davies, GD Kirkpatrick, D Zhang, ... Molecular cancer therapeutics 14 (9), 2014-2022, 2015 | 63 | 2015 |
The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia KA Minson, CC Smith, D DeRyckere, C Libbrecht, AB Lee-Sherick, ... JCI insight 1 (3), 2016 | 61 | 2016 |
Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia AB Lee-Sherick, W Zhang, KK Menachof, AA Hill, S Rinella, G Kirkpatrick, ... Oncotarget 6 (9), 6722, 2015 | 49 | 2015 |
Discovery of macrocyclic pyrimidines as MerTK‐specific inhibitors AL McIver, W Zhang, Q Liu, X Jiang, MA Stashko, J Nichols, MJ Miley, ... ChemMedChem 12 (3), 207-213, 2017 | 31 | 2017 |
The small‐molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis BR Branchford, TJ Stalker, L Law, G Acevedo, S Sather, C Brzezinski, ... Journal of thrombosis and haemostasis 16 (2), 352-363, 2018 | 29 | 2018 |
Design and synthesis of novel macrocyclic Mer tyrosine kinase inhibitors X Wang, J Liu, W Zhang, MA Stashko, J Nichols, MJ Miley, J Norris-Drouin, ... ACS medicinal chemistry letters 7 (12), 1044-1049, 2016 | 25 | 2016 |
Highly selective MERTK inhibitors achieved by a single methyl group J Zhao, D Zhang, W Zhang, MA Stashko, D DeRyckere, E Vasileiadi, ... Journal of Medicinal Chemistry 61 (22), 10242-10254, 2018 | 21 | 2018 |
Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity X Wang, W Zhang, S Frye US Patent 9,649,309, 2017 | 21 | 2017 |
Berotralstat (BCX7353): structure-guided design of a potent, selective, and oral plasma kallikrein inhibitor to prevent attacks of hereditary angioedema (HAE) PL Kotian, M Wu, S Vadlakonda, V Chintareddy, P Lu, L Juarez, ... Journal of Medicinal Chemistry 64 (17), 12453-12468, 2021 | 18 | 2021 |
Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma JP Wong, TJ Stuhlmiller, LC Giffin, C Lin, R Bigi, J Zhao, W Zhang, ... Proceedings of the National Academy of Sciences 116 (33), 16541-16550, 2019 | 18 | 2019 |
Superstable magnetic nanoreactors with high efficiency for Suzuki-coupling reactions W Zhang, X Chen, T Tang, E Mijowska Nanoscale 6 (21), 12884-12889, 2014 | 16 | 2014 |