| MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis AL Samson, Y Zhang, ND Geoghegan, XJ Gavin, KA Davies, ... Nature communications 11 (1), 3151, 2020 | 218 | 2020 |
| A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction JM Hildebrand, M Kauppi, IJ Majewski, Z Liu, AJ Cox, S Miyake, EJ Petrie, ... Nature communications 11 (1), 3150, 2020 | 70 | 2020 |
| Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies EJ Petrie, RW Birkinshaw, A Koide, E Denbaum, JM Hildebrand, ... Proceedings of the National Academy of Sciences 117 (15), 8468-8475, 2020 | 62 | 2020 |
| Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis SE Garnish, Y Meng, A Koide, JJ Sandow, E Denbaum, AV Jacobsen, ... Nature communications 12 (1), 2211, 2021 | 60 | 2021 |
| Location, location, location: a compartmentalized view of TNF-induced necroptotic signaling AL Samson, SE Garnish, JM Hildebrand, JM Murphy Science signaling 14 (668), eabc6178, 2021 | 54 | 2021 |
| Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis Y Meng, KA Davies, C Fitzgibbon, SN Young, SE Garnish, CR Horne, ... Nature Communications 12 (1), 6783, 2021 | 53 | 2021 |
| Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues KA Davies, C Fitzgibbon, SN Young, SE Garnish, W Yeung, D Coursier, ... Nature Communications 11 (1), 3060, 2020 | 48 | 2020 |
| Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis Z Liu, LF Dagley, K Shield‐Artin, SN Young, A Bankovacki, X Wang, ... The EMBO journal 40 (23), e103718, 2021 | 47 | 2021 |
| Potent inhibition of necroptosis by simultaneously targeting multiple effectors of the pathway CL Pierotti, MC Tanzer, AV Jacobsen, JM Hildebrand, JM Garnier, ... ACS Chemical Biology 15 (10), 2702-2713, 2020 | 24 | 2020 |
| Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL A Sethi, CR Horne, C Fitzgibbon, K Wilde, KA Davies, SE Garnish, ... Cell Death & Differentiation 29 (9), 1804-1815, 2022 | 23 | 2022 |
| The role of the key effector of necroptotic cell death, MLKL, in mouse models of disease EC Tovey Crutchfield, SE Garnish, JM Hildebrand Biomolecules 11 (6), 803, 2021 | 14 | 2021 |
| MLKL deficiency protects against low-grade, sterile inflammation in aged mice EC Tovey Crutchfield, SE Garnish, J Day, H Anderton, S Chiou, A Hempel, ... Cell Death & Differentiation 30 (4), 1059-1071, 2023 | 5 | 2023 |
| A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation SE Garnish, KR Martin, M Kauppi, VE Jackson, R Ambrose, VV Eng, ... Nature Communications 14 (1), 6046, 2023 | 4 | 2023 |
| Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death D Frank, SE Garnish, JJ Sandow, A Weir, L Liu, E Clayer, L Meza, ... Iscience 25 (7), 2022 | 4 | 2022 |
| Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway SE Garnish, JM Hildebrand Biochemical Society Transactions 50 (1), 529-539, 2022 | 3 | 2022 |
| Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization Y Meng, SE Garnish, KA Davies, KA Black, AP Leis, CR Horne, ... Nature Communications 14 (1), 6804, 2023 | 2 | 2023 |
| Add necroptosis to your asthma action plan SE Garnish, ECT Crutchfield, JM Murphy, JM Hildebrand, SE Garnish, ... Immunology and Cell Biology 99 (8), 800-802, 2021 | 1 | 2021 |
| MLKL deficiency protects against low-grade, sterile inflammation in aged mice ECT Crutchfield, SE Garnish, J Day, H Anderton, S Chiou, A Hempel, ... Cell Death and Differentiation 30 (4), 1059, 2023 | | 2023 |
