| Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl … E Pinard, A Alanine, D Alberati, M Bender, E Borroni, P Bourdeaux, ... Journal of medicinal chemistry 53 (12), 4603-4614, 2010 | 186 | 2010 |
| β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer’s disease H Hilpert, W Guba, TJ Woltering, W Wostl, E Pinard, H Mauser, ... Journal of medicinal chemistry 56 (10), 3980-3995, 2013 | 154 | 2013 |
| Pyrido [2, 1-a] isoquinoline derivatives LC Gobbi, T Luebbers, P Mattei, R Narquizian, PC Wyss US Patent 6,727,261, 2004 | 139 | 2004 |
| Pyrido [2, 1-a] isoquinoline derivatives M Boehringer, B Kuhn, T Luebbers, P Mattei, R Narquizian, HP Wessel US Patent 7,718,666, 2010 | 114 | 2010 |
| Pyrido [2, 1-a] isoquinoline derivatives M Boehringer, B Kuhn, P Mattei, R Narquizian US Patent 7,122,555, 2006 | 114 | 2006 |
| Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice H Jacobsen, L Ozmen, A Caruso, R Narquizian, H Hilpert, B Jacobsen, ... Journal of Neuroscience 34 (35), 11621-11630, 2014 | 113 | 2014 |
| Discovery of Functionally Selective 7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABAA Receptor Agonists at the α3 Subunit MGN Russell, RW Carling, JR Atack, FA Bromidge, SM Cook, P Hunt, ... Journal of medicinal chemistry 48 (5), 1367-1383, 2005 | 78 | 2005 |
| Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes P Mattei, M Boehringer, P Di Giorgio, H Fischer, M Hennig, J Huwyler, ... Bioorganic & medicinal chemistry letters 20 (3), 1109-1113, 2010 | 77 | 2010 |
| BACE1 inhibitors: A head group scan on a series of amides TJ Woltering, W Wostl, H Hilpert, M Rogers-Evans, E Pinard, A Mayweg, ... Bioorganic & medicinal chemistry letters 23 (14), 4239-4243, 2013 | 69 | 2013 |
| Synthetic studies on the pederin family of antitumour agents. Syntheses of mycalamide B, theopederin D and pederin P Kocienski, R Narquizian, P Raubo, C Smith, LJ Farrugia, K Muir, ... Journal of the Chemical Society, Perkin Transactions 1, 2357-2384, 2000 | 66 | 2000 |
| 3-amino-5-phenyl-5, 6-dihydro-2H-[1, 4] oxazines M Andreini, D Banner, W Guba, H Hilpert, H Mauser, AV Mayweg, ... US Patent 8,188,079, 2012 | 64 | 2012 |
| Pyrido [2, 1-a] isoquinoline derivatives LC Gobbi, T Luebbers, P Mattei, R Narquizian, PC Wyss US Patent 6,897,222, 2005 | 57 | 2005 |
| Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity L Alig, J Alsenz, M Andjelkovic, S Bendels, A Bénardeau, K Bleicher, ... Journal of medicinal chemistry 51 (7), 2115-2127, 2008 | 55 | 2008 |
| Bi-and tricyclic substituted phenyl methanones S Jolidon, R Narquizian, RD Norcross, E Pinard US Patent 7,375,226, 2008 | 53 | 2008 |
| Substituted acylpiperazine derivatives D Alberati-Giani, S Jolidon, R Narquizian, MH Nettekoven, RD Norcross, ... US Patent 7,462,617, 2008 | 51 | 2008 |
| 1, 3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo [a] quinolizine dipeptidyl peptidase IV inhibitors T Lübbers, M Böhringer, L Gobbi, M Hennig, D Hunziker, B Kuhn, B Löffler, ... Bioorganic & medicinal chemistry letters 17 (11), 2966-2970, 2007 | 50 | 2007 |
| Aryl-and heteroaryl-substituted aminobenzo [a] quinolizines as dipeptidyl peptidase IV inhibitors M Boehringer, H Fischer, M Hennig, D Hunziker, J Huwyler, B Kuhn, ... Bioorganic & medicinal chemistry letters 20 (3), 1106-1108, 2010 | 48 | 2010 |
| The pederin family of antitumor agents: structures, synthesis and biological activity R Narquizian, PJ Kocienski The role of natural products in drug discovery, 25-56, 2000 | 46 | 2000 |
| Benzoyl-piperazine derivatives S Jolidon, R Narquizian, MH Nettekoven, RD Norcross, E Pinard, ... US Patent 7,319,099, 2008 | 42 | 2008 |
| Benzoyl-piperazine derivatives D Alberati-Giani, S Jolidon, R Narquizian, MH Nettekoven, RD Norcross, ... US Patent 7,427,612, 2008 | 40 | 2008 |
