| Coenzyme A biosynthesis: an antimicrobial drug target C Spry, K Kirk, KJ Saliba FEMS microbiology reviews 32 (1), 56-106, 2008 | 308 | 2008 |
| Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated C Spry, C Macuamule, Z Lin, KG Virga, RE Lee, E Strauss, KJ Saliba PloS one 8 (2), e54974, 2013 | 111 | 2013 |
| A Class of Pantothenic Acid Analogs Inhibits Plasmodium falciparum Pantothenate Kinase and Represses the Proliferation of Malaria Parasites C Spry, CLL Chai, K Kirk, KJ Saliba Antimicrobial agents and chemotherapy 49 (11), 4649-4657, 2005 | 109 | 2005 |
| Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity M de Villiers, C Macuamule, C Spry, YM Hyun, E Strauss, KJ Saliba ACS medicinal chemistry letters 4 (8), 784-789, 2013 | 70 | 2013 |
| Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy C Spry, DA Van Schalkwyk, E Strauss, KJ Saliba Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2010 | 46 | 2010 |
| The human malaria parasite Plasmodium falciparum is not dependent on host coenzyme A biosynthesis C Spry, KJ Saliba Journal of biological chemistry 284 (37), 24904-24913, 2009 | 34 | 2009 |
| Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides KJ Saliba, C Spry Biochemical Society Transactions 42 (4), 1087-1093, 2014 | 33 | 2014 |
| Antiplasmodial mode of action of pantothenamides: pantothenate kinase serves as a metabolic activator, not as a target M de Villiers, C Spry, CJ Macuamule, L Barnard, G Wells, KJ Saliba, ... ACS Infectious Diseases, 2017 | 32 | 2017 |
| Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues ET Tjhin, C Spry, AL Sewell, A Hoegl, L Barnard, AE Sexton, G Siddiqui, ... PLoS Pathogens 14 (4), e1006918, 2018 | 28 | 2018 |
| Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite AM Lehane, RV Marchetti, C Spry, DA van Schalkwyk, R Teng, K Kirk, ... Journal of Biological Chemistry 282 (35), 25395-25405, 2007 | 24 | 2007 |
| Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure–Activity Relationship Studies of N-Phenethyl-α-methyl-pantothenamide C Spry, L Barnard, M Kok, AK Powell, D Mahesh, ET Tjhin, KJ Saliba, ... ACS Infectious Diseases 6 (7), 1844-1854, 2020 | 21 | 2020 |
| Differential scanning fluorimetry as part of a biophysical screening cascade DE Scott, C Spry, C Abell Fragment‐based Drug Discovery Lessons and Outlook, 139-172, 2016 | 20 | 2016 |
| Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation C Spry, AL Sewell, Y Hering, MVJ Villa, J Weber, SJ Hobson, SJ Harnor, ... European Journal of Medicinal Chemistry 143, 1139-1147, 2018 | 19 | 2018 |
| A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices C Spry, KJ Saliba, E Strauss Analytical biochemistry 451, 76-78, 2014 | 15 | 2014 |
| Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides J Guan, C Spry, ET Tjhin, P Yang, T Kittikool, VM Howieson, H Ling, ... Journal of Medicinal Chemistry 64 (8), 4478-4497, 2021 | 13 | 2021 |
| Structure–activity relationships of antiplasmodial pantothenamide analogues reveal a new way by which triazoles mimic amide bonds J Guan, ET Tjhin, VM Howieson, T Kittikool, C Spry, KJ Saliba, K Auclair ChemMedChem 13 (24), 2677-2683, 2018 | 13 | 2018 |
| Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site V Mendes, SR Green, JC Evans, J Hess, M Blaszczyk, C Spry, O Bryant, ... Nature communications 12 (1), 143, 2021 | 12 | 2021 |
| A novel heteromeric pantothenate kinase complex in apicomplexan parasites ET Tjhin, VM Howieson, C Spry, GG van Dooren, KJ Saliba PLoS Pathogens 17 (7), e1009797, 2021 | 10 | 2021 |
| A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites JA Hayward, FV Makota, D Cihalova, RA Leonard, E Rajendran, ... PLoS Pathogens 19 (7), e1011517, 2023 | 8 | 2023 |
| Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference** J El Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, I Fathoni, ... Angewandte Chemie 135 (17), e202300221, 2023 | 5 | 2023 |
