| ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists J Madrenas, RL Wange, JL Wang, N Isakov, LE Samelson, RN Germain Science 267 (5197), 515-518, 1995 | 630 | 1995 |
| T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation T Mustelin, KM Coggeshall, N Isakov, A Altman Science 247 (4950), 1584-1587, 1990 | 558 | 1990 |
| PROTEIN KINASE Cθ IN T CELL ACTIVATION N Isakov, A Altman Annual review of immunology 20 (1), 761-794, 2002 | 493 | 2002 |
| Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. G Baier, D Telford, L Giampa, KM Coggeshall, G Baier-Bitterlich, N Isakov, ... Journal of Biological Chemistry 268 (7), 4997-5004, 1993 | 367 | 1993 |
| T‐lymphocyte activation: The role of protein kinase C and the bifurcating inositol phospholipid signal transduction pathway N Isakov, MI Mally, W Scholz, A Altman Immunological Reviews 95 (1), 89-111, 1987 | 255 | 1987 |
| High red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance S Zelber-Sagi, D Ivancovsky-Wajcman, NF Isakov, M Webb, D Orenstein, ... Journal of hepatology 68 (6), 1239-1246, 2018 | 254 | 2018 |
| ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying … N Isakov, RL Wange, WH Burgess, JD Watts, R Aebersold, LE Samelson The Journal of experimental medicine 181 (1), 375-380, 1995 | 250 | 1995 |
| Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-κB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain S Witte, M Villalba, K Bi, Y Liu, N Isakov, A Altman Journal of Biological Chemistry 275 (3), 1902-1909, 2000 | 247 | 2000 |
| Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70 (∗) RL Wange, R Guitián, N Isakov, JD Watts, R Aebersold, LE Samelson Journal of Biological Chemistry 270 (32), 18730-18733, 1995 | 243 | 1995 |
| Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression N Isakov Seminars in cancer biology 48, 36-52, 2018 | 239 | 2018 |
| Protein kinase Cθ: a new essential superstar on the T-cell stage A Altman, N Isakov, G Baier Immunology today 21 (11), 567-573, 2000 | 216 | 2000 |
| Direct interaction between protein kinase Cθ (PKCθ) and 14-3-3τ in T cells: 14-3-3 overexpression results in inhibition of PKCθ translocation and function N Meller, YC Liu, TL Collins, N Bonnefoy-Bérard, G Baier, N Isakov, ... Molecular and Cellular Biology 16 (10), 5782-5791, 1996 | 192 | 1996 |
| Immunoreceptor tyrosine‐based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades N Isakov Journal of leukocyte biology 61 (1), 6-16, 1997 | 180 | 1997 |
| Signal transduction and intracellular events in T-lymphocyte activation N Isakov, W Scholz, A Altman Immunology Today 7 (9), 271-277, 1986 | 170 | 1986 |
| A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28 KF Kong, T Yokosuka, AJ Canonigo-Balancio, N Isakov, T Saito, A Altman Nature immunology 12 (11), 1105-1112, 2011 | 159 | 2011 |
| ITIMs and ITAMs: the yin and yang of antigen and Fc receptor-linked signaling machinery N Isakov Immunologic research 16, 85-100, 1997 | 129 | 1997 |
| Human T lymphocyte activation by tumor promoters: role of protein kinase C. N Isakov, A Altman Journal of immunology (Baltimore, Md.: 1950) 138 (10), 3100-3107, 1987 | 125 | 1987 |
| Selective post-transcriptional down-regulation of protein kinase C isoenzymes in leukemic T cells chronically treated with phorbol ester. N Isakov, P McMahon, A Altman Journal of Biological Chemistry 265 (4), 2091-2097, 1990 | 121 | 1990 |
| Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes. N Isakov, A Altman Journal of immunology (Baltimore, Md.: 1950) 135 (6), 3674-3680, 1985 | 108 | 1985 |
| Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C. N Isakov, D Galron, T Mustelin, GR Pettit, A Altman Journal of immunology (Baltimore, Md.: 1950) 150 (4), 1195-1204, 1993 | 104 | 1993 |
