Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA J Parsons, MP Castaldi, S Dutta, SM Dibrov, DL Wyles, T Hermann Nature chemical biology 5 (11), 823-825, 2009 | 180 | 2009 |
EED-targeted PROTACs degrade EED, EZH2, and SUZ12 in the PRC2 complex JHR Hsu, T Rasmusson, J Robinson, F Pachl, J Read, S Kawatkar, ... Cell chemical biology 27 (1), 41-46. e17, 2020 | 157 | 2020 |
Development of a novel B-cell lymphoma 6 (BCL6) PROTAC to provide insight into small molecule targeting of BCL6 W McCoull, T Cheung, E Anderson, P Barton, J Burgess, K Byth, Q Cao, ... ACS Chemical Biology 13 (11), 3131-3141, 2018 | 129 | 2018 |
Proteolysis‐targeting chimeras in drug development: a safety perspective K Moreau, M Coen, AX Zhang, F Pachl, MP Castaldi, G Dahl, H Boyd, ... British journal of pharmacology 177 (8), 1709-1718, 2020 | 118 | 2020 |
C3 symmetry: molecular design inspired by nature SE Gibson, MP Castaldi Angewandte Chemie International Edition 45 (29), 4718-4720, 2006 | 104 | 2006 |
Stereoselective synthesis of spirocyclic oxindoles via prins cyclizations MP Castaldi, DM Troast, JA Porco Jr Organic letters 11 (15), 3362-3365, 2009 | 102 | 2009 |
Dependence on the pyrimidine biosynthetic enzyme DHODH is a synthetic lethal vulnerability in mutant KRAS-driven cancers M Koundinya, J Sudhalter, A Courjaud, B Lionne, G Touyer, L Bonnet, ... Cell chemical biology 25 (6), 705-717. e11, 2018 | 85 | 2018 |
Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site: Miniperspective SM Dibrov, J Parsons, M Carnevali, S Zhou, KD Rynearson, K Ding, ... Journal of medicinal chemistry 57 (5), 1694-1707, 2014 | 79 | 2014 |
CETSA beyond soluble targets: a broad application to multipass transmembrane proteins A Kawatkar, M Schefter, NO Hermansson, A Snijder, N Dekker, DG Brown, ... ACS chemical biology 14 (9), 1913-1920, 2019 | 63 | 2019 |
Applications of chiral C 3-symmetric molecules SE Gibson, MP Castaldi Chemical communications, 3045-3062, 2006 | 63 | 2006 |
Small‐molecule stabilization of the p53–14‐3‐3 protein‐protein interaction RG Doveston, A Kuusk, SA Andrei, S Leysen, Q Cao, MP Castaldi, ... FEBS letters 591 (16), 2449-2457, 2017 | 46 | 2017 |
A New Approach to Enantiopure C3‐Symmetric Molecules MP Castaldi, SE Gibson, M Rudd, AJP White Chemistry–A European Journal 12 (1), 138-148, 2006 | 42 | 2006 |
Fragment-based differential targeting of PPI stabilizer interfaces X Guillory, M Wolter, S Leysen, JF Neves, A Kuusk, S Genet, B Somsen, ... Journal of medicinal chemistry 63 (13), 6694-6707, 2020 | 36 | 2020 |
C3‐Symmetrie: Molekülentwürfe nach der Natur SE Gibson, MP Castaldi Angewandte Chemie 118 (29), 4834-4837, 2006 | 32 | 2006 |
Introduction of Multiple Elements of Chirality around an Aromatic Core and an Approach to Enantiomerically Pure C3‐Symmetric Ligands MP Castaldi, SE Gibson, M Rudd, AJP White Angewandte Chemie 117 (22), 3498-3501, 2005 | 29 | 2005 |
Chemical instability and promiscuity of arylmethylidenepyrazolinone-based MDMX inhibitors J Stefaniak, AM Lewis, D Conole, SRG Galan, CJR Bataille, GM Wynne, ... ACS Chemical Biology 13 (10), 2849-2854, 2018 | 16 | 2018 |
Design, synthesis, and strategic use of small chemical probes toward identification of novel targets for drug development MP Castaldi, JA Hendricks, AX Zhang Current Opinion in Chemical Biology 56, 91-97, 2020 | 13 | 2020 |
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance L Wrobel, SM Hill, A Djajadikerta, M Fernandez-Estevez, C Karabiyik, ... Nature Communications 13 (1), 4146, 2022 | 12 | 2022 |
Affinity-bead assisted mass spectrometry (Affi-BAMS): a multiplexed microarray platform for targeted proteomics GM Hamza, VB Bergo, S Mamaev, DM Wojchowski, P Toran, CR Worsfold, ... International Journal of Molecular Sciences 21 (6), 2016, 2020 | 12 | 2020 |
Modulating antibody structure and function through directed mutations and chemical rescue CE Kaiser, JP Rincon Pabon, J Khowsathit, MP Castaldi, SL Kazmirski, ... ACS synthetic biology 7 (4), 1152-1162, 2018 | 7 | 2018 |