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M Paola Castaldi
M Paola Castaldi
Head of Platform & Chemical Biology @ Matchpoint Therapeutics
Verified email at matchpointtx.com
Title
Cited by
Cited by
Year
Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA
J Parsons, MP Castaldi, S Dutta, SM Dibrov, DL Wyles, T Hermann
Nature chemical biology 5 (11), 823-825, 2009
1802009
EED-targeted PROTACs degrade EED, EZH2, and SUZ12 in the PRC2 complex
JHR Hsu, T Rasmusson, J Robinson, F Pachl, J Read, S Kawatkar, ...
Cell chemical biology 27 (1), 41-46. e17, 2020
1572020
Development of a novel B-cell lymphoma 6 (BCL6) PROTAC to provide insight into small molecule targeting of BCL6
W McCoull, T Cheung, E Anderson, P Barton, J Burgess, K Byth, Q Cao, ...
ACS Chemical Biology 13 (11), 3131-3141, 2018
1292018
Proteolysis‐targeting chimeras in drug development: a safety perspective
K Moreau, M Coen, AX Zhang, F Pachl, MP Castaldi, G Dahl, H Boyd, ...
British journal of pharmacology 177 (8), 1709-1718, 2020
1182020
C3 symmetry: molecular design inspired by nature
SE Gibson, MP Castaldi
Angewandte Chemie International Edition 45 (29), 4718-4720, 2006
1042006
Stereoselective synthesis of spirocyclic oxindoles via prins cyclizations
MP Castaldi, DM Troast, JA Porco Jr
Organic letters 11 (15), 3362-3365, 2009
1022009
Dependence on the pyrimidine biosynthetic enzyme DHODH is a synthetic lethal vulnerability in mutant KRAS-driven cancers
M Koundinya, J Sudhalter, A Courjaud, B Lionne, G Touyer, L Bonnet, ...
Cell chemical biology 25 (6), 705-717. e11, 2018
852018
Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site: Miniperspective
SM Dibrov, J Parsons, M Carnevali, S Zhou, KD Rynearson, K Ding, ...
Journal of medicinal chemistry 57 (5), 1694-1707, 2014
792014
CETSA beyond soluble targets: a broad application to multipass transmembrane proteins
A Kawatkar, M Schefter, NO Hermansson, A Snijder, N Dekker, DG Brown, ...
ACS chemical biology 14 (9), 1913-1920, 2019
632019
Applications of chiral C 3-symmetric molecules
SE Gibson, MP Castaldi
Chemical communications, 3045-3062, 2006
632006
Small‐molecule stabilization of the p53–14‐3‐3 protein‐protein interaction
RG Doveston, A Kuusk, SA Andrei, S Leysen, Q Cao, MP Castaldi, ...
FEBS letters 591 (16), 2449-2457, 2017
462017
A New Approach to Enantiopure C3‐Symmetric Molecules
MP Castaldi, SE Gibson, M Rudd, AJP White
Chemistry–A European Journal 12 (1), 138-148, 2006
422006
Fragment-based differential targeting of PPI stabilizer interfaces
X Guillory, M Wolter, S Leysen, JF Neves, A Kuusk, S Genet, B Somsen, ...
Journal of medicinal chemistry 63 (13), 6694-6707, 2020
362020
C3‐Symmetrie: Molekülentwürfe nach der Natur
SE Gibson, MP Castaldi
Angewandte Chemie 118 (29), 4834-4837, 2006
322006
Introduction of Multiple Elements of Chirality around an Aromatic Core and an Approach to Enantiomerically Pure C3‐Symmetric Ligands
MP Castaldi, SE Gibson, M Rudd, AJP White
Angewandte Chemie 117 (22), 3498-3501, 2005
292005
Chemical instability and promiscuity of arylmethylidenepyrazolinone-based MDMX inhibitors
J Stefaniak, AM Lewis, D Conole, SRG Galan, CJR Bataille, GM Wynne, ...
ACS Chemical Biology 13 (10), 2849-2854, 2018
162018
Design, synthesis, and strategic use of small chemical probes toward identification of novel targets for drug development
MP Castaldi, JA Hendricks, AX Zhang
Current Opinion in Chemical Biology 56, 91-97, 2020
132020
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
L Wrobel, SM Hill, A Djajadikerta, M Fernandez-Estevez, C Karabiyik, ...
Nature Communications 13 (1), 4146, 2022
122022
Affinity-bead assisted mass spectrometry (Affi-BAMS): a multiplexed microarray platform for targeted proteomics
GM Hamza, VB Bergo, S Mamaev, DM Wojchowski, P Toran, CR Worsfold, ...
International Journal of Molecular Sciences 21 (6), 2016, 2020
122020
Modulating antibody structure and function through directed mutations and chemical rescue
CE Kaiser, JP Rincon Pabon, J Khowsathit, MP Castaldi, SL Kazmirski, ...
ACS synthetic biology 7 (4), 1152-1162, 2018
72018
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