| Clinical and biomarker changes in dominantly inherited Alzheimer's disease RJ Bateman, C Xiong, TLS Benzinger, AM Fagan, A Goate, NC Fox, ... New England Journal of Medicine 367 (9), 795-804, 2012 | 3966 | 2012 |
| Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ... Nature genetics 51 (3), 414-430, 2019 | 2162 | 2019 |
| Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ... Nature genetics 43 (5), 436-441, 2011 | 2134 | 2011 |
| Mutation in the tau gene in familial multiple system tauopathy with presenile dementia MG Spillantini, JR Murrell, M Goedert, MR Farlow, A Klug, B Ghetti Proceedings of the National Academy of Sciences 95 (13), 7737-7741, 1998 | 1792 | 1998 |
| Cryo-EM structures of tau filaments from Alzheimer’s disease AWP Fitzpatrick, B Falcon, S He, AG Murzin, G Murshudov, HJ Garringer, ... Nature 547 (7662), 185-190, 2017 | 1744 | 2017 |
| Classification of sporadic Creutzfeldt‐Jakob disease based on molecular and phenotypic analysis of 300 subjects P Parchi, A Giese, S Capellari, P Brown, W Schulz‐Schaeffer, O Windl, ... Annals of neurology 46 (2), 224-233, 1999 | 1606 | 1999 |
| A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease J Murrell, M Farlow, B Ghetti, MD Benson Science 254 (5028), 97-99, 1991 | 1537 | 1991 |
| Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update IRA Mackenzie, M Neumann, EH Bigio, NJ Cairns, I Alafuzoff, J Kril, ... Acta neuropathologica 119, 1-4, 2010 | 1138 | 2010 |
| Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology R Radde, T Bolmont, SA Kaeser, J Coomaraswamy, D Lindau, L Stoltze, ... EMBO reports 7 (9), 940-946, 2006 | 1081 | 2006 |
| Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition KR Bales, T Verina, RC Dodel, Y Du, L Altstiel, M Bender, P Hyslop, ... Nature genetics 17 (3), 263-264, 1997 | 1078 | 1997 |
| Molecular basis of phenotypic variability in sporadc creudeldt‐jakob disease P Parchi, R Castellani, S Capellari, B Ghetti, K Young, SG Chen, M Farlow, ... Annals of neurology 39 (6), 767-778, 1996 | 1017 | 1996 |
| Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ... Nature genetics 49 (9), 1373-1384, 2017 | 897 | 2017 |
| Brain homogenates from human tauopathies induce tau inclusions in mouse brain F Clavaguera, H Akatsu, G Fraser, RA Crowther, S Frank, J Hench, ... Proceedings of the National Academy of Sciences 110 (23), 9535-9540, 2013 | 801 | 2013 |
| Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein B Allen, E Ingram, M Takao, MJ Smith, R Jakes, K Virdee, H Yoshida, ... Journal of Neuroscience 22 (21), 9340-9351, 2002 | 789 | 2002 |
| Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease O Preische, SA Schultz, A Apel, J Kuhle, SA Kaeser, C Barro, S Gräber, ... Nature medicine 25 (2), 277-283, 2019 | 730 | 2019 |
| Structures of filaments from Pick’s disease reveal a novel tau protein fold B Falcon, W Zhang, AG Murzin, G Murshudov, HJ Garringer, R Vidal, ... Nature 561 (7721), 137-140, 2018 | 709 | 2018 |
| Apolipoprotein E is essential for amyloid deposition in the APPV717F transgenic mouse model of Alzheimer's disease KR Bales, T Verina, DJ Cummins, Y Du, RC Dodel, J Saura, CE Fishman, ... Proceedings of the National Academy of Sciences 96 (26), 15233-15238, 1999 | 634 | 1999 |
| Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy GU Höglinger, NM Melhem, DW Dickson, PMA Sleiman, LS Wang, L Klei, ... Nature genetics 43 (7), 699-705, 2011 | 616 | 2011 |
| Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes CF Lippa, H Fujiwara, DMA Mann, B Giasson, M Baba, ML Schmidt, ... The American journal of pathology 153 (5), 1365-1370, 1998 | 597 | 1998 |
| Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules B Falcon, J Zivanov, W Zhang, AG Murzin, HJ Garringer, R Vidal, ... Nature 568 (7752), 420-423, 2019 | 593 | 2019 |
