| How to measure and predict the molar absorption coefficient of a protein CN Pace, F Vajdos, L Fee, G Grimsley, T Gray Protein science 4 (11), 2411-2423, 1995 | 4974 | 1995 |
| Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex MC Franklin, KD Carey, FF Vajdos, DJ Leahy, AM De Vos, MX Sliwkowski Cancer cell 5 (4), 317-328, 2004 | 1402 | 2004 |
| Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid TR Gamble, FF Vajdos, S Yoo, DK Worthylake, M Houseweart, ... Cell 87 (7), 1285-1294, 1996 | 910 | 1996 |
| Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis FF Vajdos, CW Adams, TN Breece, LG Presta, AM de Vos, SS Sidhu Journal of molecular biology 320 (2), 415-428, 2002 | 835 | 2002 |
| Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein TR Gamble, S Yoo, FF Vajdos, UK Von Schwedler, DK Worthylake, ... Science 278 (5339), 849-853, 1997 | 773 | 1997 |
| Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271 WG Roberts, E Ung, P Whalen, B Cooper, C Hulford, C Autry, D Richter, ... Cancer research 68 (6), 1935-1944, 2008 | 426 | 2008 |
| Structural insights into the catalytic mechanism of cyclophilin A BR Howard, FF Vajdos, S Li, WI Sundquist, CP Hill Nature Structural & Molecular Biology 10 (6), 475-481, 2003 | 184 | 2003 |
| Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition JB Telliez, ME Dowty, LU Wang, J Jussif, T Lin, L Li, E Moy, P Balbo, W Li, ... ACS chemical biology 11 (12), 3442-3451, 2016 | 149 | 2016 |
| Suppressor of fused regulates Gli activity through a dual binding mechanism M Merchant, FF Vajdos, M Ultsch, HR Maun, U Wendt, J Cannon, ... Molecular and cellular biology 24 (19), 8627-8641, 2004 | 147 | 2004 |
| Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF … A Thorarensen, ME Dowty, ME Banker, B Juba, J Jussif, T Lin, F Vincent, ... Journal of medicinal chemistry 60 (5), 1971-1993, 2017 | 132 | 2017 |
| Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV‐1 capsid protein FF Vajdos, S Yoo, M Houseweart, WI Sundquist, CP Hill Protein science 6 (11), 2297-2307, 1997 | 129 | 1997 |
| Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl … A Fensome, CM Ambler, E Arnold, ME Banker, MF Brown, J Chrencik, ... Journal of medicinal chemistry 61 (19), 8597-8612, 2018 | 127 | 2018 |
| Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions FF Vajdos, M Ultsch, ML Schaffer, KD Deshayes, J Liu, NJ Skelton, ... Biochemistry 40 (37), 11022-11029, 2001 | 120 | 2001 |
| Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes DA Griffith, DW Kung, WP Esler, PA Amor, SW Bagley, C Beysen, ... Journal of medicinal chemistry 57 (24), 10512-10526, 2014 | 81 | 2014 |
| Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design IV Efremov, FF Vajdos, KA Borzilleri, S Capetta, H Chen, PH Dorff, ... Journal of medicinal chemistry 55 (21), 9069-9088, 2012 | 80 | 2012 |
| Spirocyclic sulfamides as β-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer’s disease: Utilization of structure based drug design, watermap, and CNS penetration … MA Brodney, G Barreiro, K Ogilvie, E Hajos-Korcsok, J Murray, F Vajdos, ... Journal of medicinal chemistry 55 (21), 9224-9239, 2012 | 77 | 2012 |
| The 2.0 Å crystal structure of the ERα ligand‐binding domain complexed with lasofoxifene FF Vajdos, LR Hoth, KF Geoghegan, SP Simons, PK LeMotte, DE Danley, ... Protein science 16 (5), 897-905, 2007 | 71 | 2007 |
| Identification of cyanamide-based Janus kinase 3 (JAK3) covalent inhibitors A Casimiro-Garcia, JI Trujillo, F Vajdos, B Juba, ME Banker, A Aulabaugh, ... Journal of Medicinal Chemistry 61 (23), 10665-10699, 2018 | 67 | 2018 |
| Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2 JW Corbett, KD Freeman-Cook, R Elliott, F Vajdos, F Rajamohan, D Kohls, ... Bioorganic & Medicinal Chemistry Letters 20 (7), 2383-2388, 2010 | 61 | 2010 |
| Discovery of tyrosine kinase 2 (TYK2) inhibitor (PF-06826647) for the treatment of autoimmune diseases BS Gerstenberger, C Ambler, EP Arnold, ME Banker, MF Brown, JD Clark, ... Journal of Medicinal Chemistry 63 (22), 13561-13577, 2020 | 54 | 2020 |
