| High-precision simultaneous determination of multiple small kinetic isotope effects at natural abundance DA Singleton, AA Thomas Journal of the American Chemical Society 117 (36), 9357-9358, 1995 | 455 | 1995 |
| Experimental and theoretical kinetic isotope effects for asymmetric dihydroxylation. Evidence supporting a rate-limiting “(3+ 2)” cycloaddition AJ DelMonte, J Haller, KN Houk, KB Sharpless, DA Singleton, T Strassner, ... Journal of the American Chemical Society 119 (41), 9907-9908, 1997 | 345 | 1997 |
| Osmium‐catalyzed dihydroxylation of olefins in acidic media: Old process, new tricks P Dupau, R Epple, AA Thomas, VV Fokin, KB Sharpless Advanced Synthesis & Catalysis 344 (3‐4), 421-433, 2002 | 287 | 2002 |
| The catalytic asymmetric aminohydroxylation of unsaturated phosphonates AA Thomas, KB Sharpless The Journal of Organic Chemistry 64 (22), 8379-8385, 1999 | 135 | 1999 |
| Isotope effects and the distinction between synchronous, asynchronous, and stepwise Diels–Alder reactions DA Singleton, BE Schulmeier, C Hang, AA Thomas, SW Leung, ... Tetrahedron 57 (24), 5149-5160, 2001 | 104 | 2001 |
| Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments PF Kiser, AA Thomas US Patent 6,521,431, 2003 | 78 | 2003 |
| Reevaluating the substrate specificity of the L-type amino acid transporter (LAT1) HC Chien, C Colas, K Finke, S Springer, L Stoner, AA Zur, B Venteicher, ... Journal of medicinal chemistry 61 (16), 7358-7373, 2018 | 72 | 2018 |
| Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: From hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species KW Hunt, AW Cook, RJ Watts, CT Clark, G Vigers, D Smith, AT Metcalf, ... Journal of Medicinal Chemistry 56 (8), 3379-3403, 2013 | 67 | 2013 |
| Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors AA Thomas, Y Le Huerou, J De Meese, I Gunawardana, T Kaplan, ... Bioorganic & medicinal chemistry letters 18 (6), 2206-2210, 2008 | 67 | 2008 |
| Degradable cross-linking agents and cross-linked network polymers formed therewith P Kiser, A Thomas US Patent App. 10/228,398, 2003 | 62 | 2003 |
| Non-charged thiamine analogs as inhibitors of enzyme transketolase AA Thomas, J De Meese, Y Le Huerou, SA Boyd, TT Romoff, ... Bioorganic & medicinal chemistry letters 18 (2), 509-512, 2008 | 54 | 2008 |
| LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs E Augustyn, K Finke, AA Zur, L Hansen, N Heeren, HC Chien, L Lin, ... Bioorganic & medicinal chemistry letters 26 (11), 2616-2621, 2016 | 48 | 2016 |
| Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system AA Thomas, KW Hunt, M Volgraf, RJ Watts, X Liu, G Vigers, D Smith, ... Journal of Medicinal Chemistry 57 (3), 878-902, 2014 | 45 | 2014 |
| LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates AA Zur, HC Chien, E Augustyn, A Flint, N Heeren, K Finke, C Hernandez, ... Bioorganic & medicinal chemistry letters 26 (20), 5000-5006, 2016 | 43 | 2016 |
| Heterobicyclic thiophene compounds and methods of use JF Blake, S Boyd, J De Meese, JJ Gaudino, AL Marlow, J Seo, ... US Patent 8,003,662, 2011 | 36 | 2011 |
| Discovery of 5, 6, 7, 8-tetrahydropyrido [3, 4-d] pyrimidine inhibitors of Erk2 JF Blake, JJ Gaudino, J De Meese, P Mohr, M Chicarelli, H Tian, R Garrey, ... Bioorganic & medicinal chemistry letters 24 (12), 2635-2639, 2014 | 33 | 2014 |
| Prodrug thiamine analogs as inhibitors of the enzyme transketolase Y Le Huerou, I Gunawardana, AA Thomas, SA Boyd, J de Meese, ... Bioorganic & medicinal chemistry letters 18 (2), 505-508, 2008 | 26 | 2008 |
| Oligo-α-hydroxy ester cross-linkers: impact of cross-linker structure on biodegradable hydrogel networks KD Eichenbaum, AA Thomas, GM Eichenbaum, BR Gibney, D Needham, ... Macromolecules 38 (26), 10757-10762, 2005 | 26 | 2005 |
| 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors AA Thomas, KW Hunt, B Newhouse, RJ Watts, X Liu, G Vigers, D Smith, ... Journal of Medicinal Chemistry 57 (23), 10112-10129, 2014 | 22 | 2014 |
| Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing X Liu, H Wong, K Scearce-Levie, RJ Watts, M Coraggio, YG Shin, K Peng, ... Drug Metabolism and Disposition 41 (7), 1319-1328, 2013 | 21 | 2013 |
Steven BoydVenatorx Pharmaceuticals, Inc.Verified email at venatorx.com
