| A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1 B Zhao, F Du, P Xu, C Shu, B Sankaran, SL Bell, M Liu, Y Lei, X Gao, X Fu, ... Nature 569 (7758), 718-722, 2019 | 267 | 2019 |
| The molecular basis of tight nuclear tethering and inactivation of cGAS B Zhao, P Xu, CM Rowlett, T Jing, O Shinde, Y Lei, AP West, WR Liu, P Li Nature 587 (7835), 673-677, 2020 | 169 | 2020 |
| DDIT3 and KAT2A proteins regulate TNFRSF10A and TNFRSF10B expression in endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells T Li, L Su, Y Lei, X Liu, Y Zhang, X Liu Journal of Biological Chemistry 290 (17), 11108-11118, 2015 | 113 | 2015 |
| Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice Y Lei, C Guerra Martinez, S Torres-Odio, SL Bell, CE Birdwell, JD Bryant, ... Science advances 7 (22), eabe7548, 2021 | 61 | 2021 |
| Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells N Mu, Y Lei, Y Wang, Y Wang, Q Duan, G Ma, X Liu, L Su Apoptosis 24, 798-811, 2019 | 58 | 2019 |
| Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity Y Lei, JJ VanPortfliet, YF Chen, JD Bryant, Y Li, D Fails, S Torres-Odio, ... Cell 186 (14), 3013-3032. e22, 2023 | 54 | 2023 |
| Loss of mitochondrial protease CLPP activates type I IFN responses through the mitochondrial DNA–cGAS–STING signaling axis S Torres-Odio, Y Lei, S Gispert, A Maletzko, J Key, SS Menissy, I Wittig, ... The Journal of Immunology 206 (8), 1890-1900, 2021 | 32 | 2021 |
| Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune‐related Pathways in Mammalian Cells JD Bryant, Y Lei, JJ VanPortfliet, AD Winters, AP West Current protocols 2 (2), e372, 2022 | 25 | 2022 |
| Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease J Key, A Maletzko, A Kohli, S Gispert, S Torres-Odio, I Wittig, J Heidler, ... neurogenetics 21, 187-203, 2020 | 24 | 2020 |
| Age-dependent decline in neuron growth potential and mitochondria functions in cortical neurons TC Sutherland, A Sefiani, D Horvat, TE Huntington, Y Lei, AP West, ... Cells 10 (7), 1625, 2021 | 10 | 2021 |
| Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT I Al Khatib, J Deng, Y Lei, S Torres-Odio, GR Rojas, LE Newman, ... Human Molecular Genetics 32 (15), 2422-2440, 2023 | 7 | 2023 |
| ZBP1 sequesters cGAS in the cytoplasm and sustains type I interferon responses to mitochondrial DNA Y Lei, JJ VanPortfliet, YF Chen, JD Bryant, KB Ragan, CW Tong, LC West, ... BioRxiv, 2022.05. 30.493783, 2022 | 6 | 2022 |
| Inflammatory and interferon gene expression signatures in patients with mitochondrial disease EB Warren, EM Gordon-Lipkin, F Cheung, J Chen, A Mukherjee, R Apps, ... Journal of Translational Medicine 21 (1), 331, 2023 | 3 | 2023 |
| Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice Y Lei, CG Martinez, S Torres-Odio, SL Bell, CE Birdwell, JD Bryant, ... bioRxiv, 2020.09. 22.308171, 2020 | 2 | 2020 |
| Loss of mitochondrial protease CLPP activates type I interferon responses through the mtDNA-cGAS-STING signaling axis S Torres-Odio, Y Lei, S Gispert, A Maletzko, J Key, S Menissy, I Wittig, ... bioRxiv, 2020.08. 30.274712, 2020 | 1 | 2020 |
| Oxidative stress enhances mitochondrial DNA-dependent type I interferon responses. Y Lei, CG Martinez, P West The Journal of Immunology 200 (1_Supplement), 169.11-169.11, 2018 | 1 | 2018 |
| Defining how mitochondrial DNA stress regulates innate immune responses CG Martinez, Y Lei, P West The Journal of Immunology 200 (1_Supplement), 169.14-169.14, 2018 | 1 | 2018 |
| 3D convolutional neural networks predict cellular metabolic pathway use from fluorescence lifetime decay data L Hu, D De Hoyos, Y Lei, AP West, AJ Walsh APL bioengineering 8 (1), 2024 | | 2024 |
| Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA–cGAS–STING Signaling Axis S Torres-Odio, Y Lei, S Gispert, A Maletzko, J Key, S Menissy, I Wittig, ... The Journal of Immunology 208 (1_Supplement), 50.05-50.05, 2022 | | 2022 |
| The Age-Dependent Decline in Neuron Growth Potential in the CNS is Associated with an Age-Related Dysfunction of Neuronal Mitochondria TC Sutherland, A Sefiani, D Horvat, TE Huntington, Y Lei, AP West, ... bioRxiv, 2021.05. 14.444223, 2021 | | 2021 |
