| Molecular mechanisms in SUMO conjugation N Varejão, J Lascorz, Y Li, D Reverter Biochemical Society Transactions 48 (1), 123-135, 2020 | 63 | 2020 |
| DNA activates the Nse2/Mms21 SUMO E3 ligase in the Smc5/6 complex N Varejão, E Ibars, J Lascorz, N Colomina, J Torres‐Rosell, D Reverter The EMBO journal 37 (12), e98306, 2018 | 53 | 2018 |
| Combining structural aggregation propensity and stability predictions to redesign protein solubility M Gil-Garcia, M Bano-Polo, N Varejao, M Jamroz, A Kuriata, ... Molecular pharmaceutics 15 (9), 3846-3859, 2018 | 47 | 2018 |
| Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis F Pinheiro, N Varejão, S Esperante, J Santos, A Velázquez‐Campoy, ... The FEBS Journal 288 (1), 310-324, 2021 | 44 | 2021 |
| Immunomodulatory effects of pCramoll and rCramoll on peritoneal exudate cells (PECs) infected and non-infected with Staphylococcus aureus LCN da Silva, NMP Alves, MCAB de Castro, VRA Pereira, NVN da Paz, ... International journal of biological macromolecules 72, 848-854, 2015 | 40 | 2015 |
| The importance of a gatekeeper residue on the aggregation of transthyretin R Sant'Anna, C Braga, N Varejão, KM Pimenta, R Graña-Montes, A Alves, ... Journal of Biological Chemistry 289 (41), 28324-28337, 2014 | 39 | 2014 |
| Ferromagnetic levan composite: an affinity matrix to purify lectin R Angeli, NVN da Paz, JC Maciel, FFB Araújo, PMG Paiva, ... BioMed Research International 2009, 2009 | 36 | 2009 |
| Heterologous expression and purification of a biologically active legume lectin from Cratylia mollis seeds (CRAMOLL 1) N Varejão, M da Silva Almeida, NNT De Cicco, GC Atella, LCBB Coelho, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (9), 1917-1924, 2010 | 28 | 2010 |
| Characterization of the Unfolding Process of the Tetrameric and Dimeric Forms of Cratylia mollis Seed Lectin (CRAMOLL 1): Effects of Natural Fragmentation on … N Varejão, MTS Correia, D Foguel Biochemistry 50 (34), 7330-7340, 2011 | 24 | 2011 |
| Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation R Sant’Anna, MR Almeida, N Varejāo, P Gallego, S Esperante, P Ferreira, ... Scientific reports 7 (1), 44709, 2017 | 22 | 2017 |
| Encapsulation into Stealth Liposomes Enhances the Antitumor Action of Recombinant Cratylia mollis Lectin Expressed in Escherichia coli CRA Cunha, LCN Silva, FJF Almeida, MS Ferraz, N Varejao, ... Frontiers in microbiology 7, 1355, 2016 | 21 | 2016 |
| Structural basis for the SUMO protease activity of the atypical ubiquitin-specific protease USPL1 Y Li, N Varejão, D Reverter Nature communications 13 (1), 1819, 2022 | 19 | 2022 |
| Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs N Varejão, J Lascorz, J Codina-Fabra, G Bellí, H Borràs-Gas, ... Nature communications 12 (1), 7013, 2021 | 17 | 2021 |
| pCramoll and rCramoll as new preventive agents against the oxidative dysfunction induced by hydrogen peroxide LC Nascimento da Silva, NMP Alves, MCAB De Castro, TMM Higino, ... Oxidative medicine and cellular longevity 2015, 2015 | 17 | 2015 |
| Structure-based analysis of A19D, a variant of transthyretin involved in familial amyloid cardiomyopathy P Ferreira, O Sant’Anna, N Varejão, C Lima, S Novis, RV Barbosa, ... Plos one 8 (12), e82484, 2013 | 16 | 2013 |
| Structural mechanism for the temperature-dependent activation of the hyperthermophilic Pf2001 esterase N Varejao, RA De-Andrade, RV Almeida, CD Anobom, D Foguel, ... Structure 26 (2), 199-208. e3, 2018 | 13 | 2018 |
| Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation SA Esperante, N Varejāo, F Pinheiro, R Sant'Anna, JR Luque-Ortega, ... Journal of Biological Chemistry 297 (3), 2021 | 8 | 2021 |
| pCramoll and rCramoll lectins induce cell death in human prostate adenocarcinoma (PC-3) cells by impairment of mitochondrial homeostasis E de Oliveira Figueirôa, MA Aranda-Souza, N Varejao, FA Rossato, ... Toxicology in Vitro 43, 40-46, 2017 | 8 | 2017 |
| Development of a highly potent transthyretin amyloidogenesis inhibitor: Design, synthesis, and evaluation F Pinheiro, I Pallarès, F Peccati, A Sánchez-Morales, N Varejão, ... Journal of medicinal chemistry 65 (21), 14673-14691, 2022 | 5 | 2022 |
| Using intrinsic fluorescence to measure protein stability upon thermal and chemical denaturation N Varejão, D Reverter Plant Proteostasis: Methods and Protocols, 229-241, 2022 | 1 | 2022 |
