| Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development ZA Binder, AH Thorne, S Bakas, EP Wileyto, M Bilello, H Akbari, ... Cancer cell 34 (1), 163-177. e7, 2018 | 160 | 2018 |
| Inhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair J Ma, JA Benitez, J Li, S Miki, CP de Albuquerque, T Galatro, L Orellana, ... Cancer cell 35 (3), 504-518. e7, 2019 | 128 | 2019 |
| Inhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair J Ma, JA Benitez, J Li, S Miki, CP de Albuquerque, T Galatro, L Orellana, ... Cancer cell 35 (3), 504-518. e7, 2019 | 128 | 2019 |
| FlexServ: an integrated tool for the analysis of protein flexibility J Camps, O Carrillo, A Emperador, L Orellana, A Hospital, M Rueda, ... Bioinformatics 25 (13), 1709-1710, 2009 | 102 | 2009 |
| Large-scale conformational changes and protein function: breaking the in silico barrier L Orellana Frontiers in molecular biosciences 6, 117, 2019 | 98 | 2019 |
| Correlated motions are a fundamental property of β-sheets RB Fenwick, L Orellana, S Esteban-Martín, M Orozco, X Salvatella Nature communications 5 (1), 4070, 2014 | 96 | 2014 |
| Approaching elastic network models to molecular dynamics flexibility L Orellana, M Rueda, C Ferrer-Costa, JR Lopez-Blanco, P Chacón, ... Journal of Chemical Theory and Computation, 2010 | 77 | 2010 |
| The molecular basis for sugar import in malaria parasites DD Abdul Aziz Qureshi, Albert Suades, Rei Matsuoka, Joseph Brock, Sarah E ... Nature, 2020 | 72 | 2020 |
| Prediction and validation of protein intermediate states from structurally rich ensembles and coarse-grained simulations L Orellana, O Yoluk, O Carrillo, M Orozco, E Lindahl Nature communications 7 (1), 12575, 2016 | 66 | 2016 |
| Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9 I Winkelmann, R Matsuoka, PF Meier, D Shutin, C Zhang, L Orellana, ... The EMBO journal 39 (24), 4541-4559, 2020 | 47 | 2020 |
| Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope L Orellana, AH Thorne, R Lema, J Gustavsson, AD Parisian, A Hospital, ... Proceedings of the National Academy of Sciences 116 (20), 10009-10018, 2019 | 45 | 2019 |
| Coarse-grained Representation of Protein Flexibility. Foundations, Successes, and Shortcomings. M OROZCO, L ORELLANA, AN Naganathan, A Emperador, O Carrillo, ... Computational Chemistry Methods in Structural Biology 85, 183, 2011 | 39 | 2011 |
| Finding Conformational Transition Pathways from Discrete Molecular Dynamics Simulations P Sfriso, A Emperador, L Orellana, A Hospital, JL Gelpí, M Orozco Journal of Chemical Theory and Computation, 0 | 36 | |
| Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2 R Matsuoka, R Fudim, S Jung, C Zhang, A Bazzone, Y Chatzikyriakidou, ... Nature Structural & Molecular Biology 29 (2), 108-120, 2022 | 29 | 2022 |
| Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis. M Thulasingam, L Orellana, E Nji, S Ahmad, A Rinaldo-Matthis, ... Nature Communications 12 (1728), 2021 | 14 | 2021 |
| eBDIMS server: protein transition pathways with ensemble analysis in 2D-motion spaces L Orellana, J Gustavsson, C Bergh, O Yoluk, E Lindahl Bioinformatics 35 (18), 3505-3507, 2019 | 13 | 2019 |
| Oncogenic mutations of the EGF-Receptor ectodomain reveal an unexpected mechanism for ligand-independent activation L Orellana, A Hospital, M Orozco biorXiv, 2014 | 7 | 2014 |
| Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy L Orellana Molecular & cellular oncology 6 (5), e1630798, 2019 | 6 | 2019 |
| Protein dynamics studied by coarse-grained and atomistic theoretical approaches L Orellana Universitat de Barcelona, 2014 | 3 | 2014 |
| Understanding protein dynamics with coarse-grained models: from structures to disease L Orellana, M Orozco FEBS JOURNAL 279, 528-528, 2012 | 3 | 2012 |
Erik LindahlProfessor of Biophysics, Stockholm University & KTH, Science for Life LaboratoryVerified email at dbb.su.se
