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Daniel Lietha
Daniel Lietha
Biological Research Center Margarita Salas (CIB-CSIC)
Verified email at cib.csic.es - Homepage
Title
Cited by
Cited by
Year
Structural basis for the autoinhibition of focal adhesion kinase
D Lietha, X Cai, DFJ Ceccarelli, Y Li, MD Schaller, MJ Eck
Cell 129 (6), 1177-1187, 2007
5172007
The FERM domain: organizing the structure and function of FAK
MC Frame, H Patel, B Serrels, D Lietha, MJ Eck
Nature reviews Molecular cell biology 11 (11), 802-814, 2010
4072010
Spatial and temporal regulation of focal adhesion kinase activity in living cells
X Cai, D Lietha, DF Ceccarelli, AV Karginov, Z Rajfur, K Jacobson, ...
Molecular and cellular biology, 2008
2072008
Phosphatidylinositol 4, 5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes
GM Gońi, C Epifano, J Boskovic, M Camacho-Artacho, J Zhou, ...
Proceedings of the National Academy of Sciences 111 (31), E3177-E3186, 2014
1432014
FAK structure and regulation by membrane interactions and force in focal adhesions
P Tapial Martínez, P López Navajas, D Lietha
Biomolecules 10 (2), 179, 2020
1402020
Crystal structures of NK1–heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor
D Lietha, DY Chirgadze, B Mulloy, TL Blundell, E Gherardi
The EMBO Journal 20 (20), 5543-5555, 2001
1382001
Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation
D Lietha, MJ Eck
PloS one 3 (11), e3800, 2008
1142008
Structural and mechanistic insights into mechanoactivation of focal adhesion kinase
MS Bauer, F Baumann, C Daday, P Redondo, E Durner, MA Jobst, ...
Proceedings of the National Academy of Sciences 116 (14), 6766-6774, 2019
1022019
Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading
F Chang, C Lemmon, D Lietha, M Eck, L Romer
PloS one 6 (12), e28587, 2011
882011
The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay: elucidation of the …
M Lyon, JA Deakin, D Lietha, E Gherardi, JT Gallagher
Journal of Biological Chemistry 279 (42), 43560-43567, 2004
672004
Design, Synthesis, and Evaluation of Novel Imidazo[1,2-a][1,3,5]triazines and Their Derivatives as Focal Adhesion Kinase Inhibitors with Antitumor Activity
P Dao, N Smith, C Tomkiewicz-Raulet, E Yen-Pon, M Camacho-Artacho, ...
Journal of medicinal chemistry 58 (1), 237-251, 2015
582015
Synthesis of novel diarylamino-1, 3, 5-triazine derivatives as FAK inhibitors with anti-angiogenic activity
P Dao, R Jarray, J Le Coq, D Lietha, A Loukaci, Y Lepelletier, ...
Bioorganic & medicinal chemistry letters 23 (16), 4552-4556, 2013
582013
Structural basis of Focal Adhesion Kinase activation on lipid membranes
I Acebrón, RD Righetto, C Schoenherr, S de Buhr, P Redondo, J Culley, ...
The EMBO journal 39 (19), e104743, 2020
512020
Allosteric regulation of focal adhesion kinase by PIP2 and ATP
J Zhou, A Bronowska, J Le Coq, D Lietha, F Gräter
Biophysical journal 108 (3), 698-705, 2015
502015
Exome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of antiangiogenic therapies
RA Toledo, E Garralda, M Mitsi, T Pons, J Monsech, E Vega, Á Otero, ...
Clinical Cancer Research 24 (15), 3550-3559, 2018
442018
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange
K Takahashi, K Kanerva, L Vanharanta, L Almeida‐Souza, D Lietha, ...
The EMBO Journal 40 (14), e106871, 2021
382021
Roles of membrane domains in integrin-mediated cell adhesion
D Lietha, T Izard
International Journal of Molecular Sciences 21 (15), 5531, 2020
372020
Structural basis for interdomain communication in SHIP2 providing high phosphatase activity
J Le Coq, M Camacho-Artacho, JV Velazquez, CM Santiveri, LH Gallego, ...
Elife 6, e26640, 2017
372017
Synthesis of novel 1, 2, 4-triazine scaffold as FAK inhibitors with antitumor activity
P Dao, D Lietha, M Etheve-Quelquejeu, C Garbay, H Chen
Bioorganic & Medicinal Chemistry Letters 27 (8), 1727-1730, 2017
372017
A tethered ligand assay to probe SARS-CoV-2: ACE2 interactions
MS Bauer, S Gruber, A Hausch, PSFC Gomes, LF Milles, T Nicolaus, ...
Proceedings of the National Academy of Sciences 119 (14), e2114397119, 2022
352022
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