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Lorena Saelices Gomez
Lorena Saelices Gomez
Verified email at utsouthwestern.edu - Homepage
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Cited by
Year
Uncovering the mechanism of aggregation of human transthyretin
L Saelices, LM Johnson, WY Liang, MR Sawaya, D Cascio, P Ruchala, ...
Journal of Biological Chemistry 290 (48), 28932-28943, 2015
1542015
Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition
L Saelices, K Chung, JH Lee, W Cohn, JP Whitelegge, MD Benson, ...
Proceedings of the National Academy of Sciences 115 (29), E6741-E6750, 2018
742018
Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway
L Saelices, L Youssar, I Holdermann, S Al-Babili, J Avalos
Molecular Genetics and Genomics 278, 527-537, 2007
742007
Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors
P Krotee, SL Griner, MR Sawaya, D Cascio, JA Rodriguez, D Shi, ...
Journal of Biological Chemistry 293 (8), 2888-2902, 2018
562018
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Q Cao, DR Boyer, MR Sawaya, R Abskharon, L Saelices, BA Nguyen, ...
Nature structural & molecular biology 28 (9), 724-730, 2021
442021
Posttranscriptional Regulation of Glutamine Synthetase in the Filamentous Cyanobacterium Anabaena sp. PCC 7120: Differential Expression between Vegetative …
CV Galmozzi, L Saelices, FJ Florencio, MI Muro-Pastor
Journal of bacteriology 192 (18), 4701-4711, 2010
372010
A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils
L Saelices, BA Nguyen, K Chung, Y Wang, A Ortega, JH Lee, T Coelho, ...
Journal of Biological Chemistry 294 (15), 6130-6141, 2019
332019
Crystal structures of amyloidogenic segments of human transthyretin
L Saelices, SA Sievers, MR Sawaya, DS Eisenberg
Protein Science 27 (7), 1295-1303, 2018
272018
Mutational analysis of the inactivating factors, IF7 and IF17 from Synechocystis sp. PCC 6803: critical role of arginine amino acid residues for glutamine synthetase …
L Saelices, CV Galmozzi, FJ Florencio, MI Muro‐Pastor
Molecular microbiology 82 (4), 964-975, 2011
222011
The inhibition of cellular toxicity of amyloid-β by dissociated transthyretin
Q Cao, DH Anderson, WY Liang, J Chou, L Saelices
Journal of Biological Chemistry 295 (41), 14015-14024, 2020
202020
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2
E Tayeb-Fligelman, X Cheng, C Tai, JT Bowler, S Griner, MR Sawaya, ...
BioRxiv, 2021.03. 05.434000, 2021
192021
Dissecting the binding between glutamine synthetase and its two natively unfolded protein inhibitors
D Pantoja-Uceda, JL Neira, L Saelices, R Robles-Rengel, FJ Florencio, ...
Biochemistry 55 (24), 3370-3382, 2016
152016
Assessment of the effects of transthyretin peptide inhibitors in Drosophila models of neuropathic ATTR
L Saelices, M Pokrzywa, K Pawelek, DS Eisenberg
Neurobiology of disease 120, 118-125, 2018
142018
A core of three amino acids at the carboxyl‐terminal region of glutamine synthetase defines its regulation in cyanobacteria
L Saelices, R Robles‐Rengel, FJ Florencio, MI Muro‐Pastor
Molecular Microbiology 96 (3), 483-496, 2015
132015
O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology
AT Balana, AL Mahul-Mellier, BA Nguyen, M Horvath, A Javed, ER Hard, ...
Biorxiv, 2023
102023
The inactivating factor of glutamine synthetase IF17 is an intrinsically disordered protein, which folds upon binding to its target
L Saelices, CV Galmozzi, FJ Florencio, MI Muro-Pastor, JL Neira
Biochemistry 50 (45), 9767-9778, 2011
92011
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils
E Tayeb-Fligelman, JT Bowler, CE Tai, MR Sawaya, YX Jiang, G Garcia Jr, ...
Nature communications 14 (1), 2379, 2023
62023
Disease-associated patterns of acetylation stabilize tau fibril formation
L Li, BA Nguyen, V Mullapudi, Y Li, L Saelices, LA Joachimiak
Structure 31 (9), 1025-1037. e4, 2023
52023
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy
BA Nguyen, V Singh, S Afrin, A Yakubovska, L Wang, Y Ahmed, ...
Nature communications 15 (1), 1-12, 2024
42024
Update on disease-specific biomarkers in transthyretin cardiac amyloidosis
CJ Hood, NS Hendren, R Pedretti, LR Roth, L Saelices, JL Grodin
Current heart failure reports 19 (5), 356-363, 2022
42022
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