ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models PE Cramer, JR Cirrito, DW Wesson, CYD Lee, JC Karlo, AE Zinn, ... Science 335 (6075), 1503-1506, 2012 | 1234 | 2012 |
ApoE promotes the proteolytic degradation of Aβ Q Jiang, CY Lee, S Mandrekar, B Wilkinson, P Cramer, N Zelcer, K Mann, ... Neuron 58 (5), 681-693, 2008 | 1106 | 2008 |
The role of microglia in amyloid clearance from the AD brain CYD Lee, GE Landreth Journal of neural transmission 117 (8), 949-960, 2010 | 727 | 2010 |
Microglia mediate the clearance of soluble Aβ through fluid phase macropinocytosis S Mandrekar, Q Jiang, CYD Lee, J Koenigsknecht-Talboo, DM Holtzman, ... Journal of Neuroscience 29 (13), 4252-4262, 2009 | 472 | 2009 |
Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer’s disease models CYD Lee, A Daggett, X Gu, LL Jiang, P Langfelder, X Li, N Wang, Y Zhao, ... Neuron 97 (5), 1032-1048. e5, 2018 | 308 | 2018 |
Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels CYD Lee, W Tse, JD Smith, GE Landreth Journal of Biological Chemistry 287 (3), 2032-2044, 2012 | 198 | 2012 |
Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl/Mer family of tyrosine kinases C Grommes, CYD Lee, BL Wilkinson, Q Jiang, JL Koenigsknecht-Talboo, ... Journal of Neuroimmune Pharmacology 3 (2), 130-140, 2008 | 170 | 2008 |
Fibrillar β-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia B Wilkinson, J Koenigsknecht-Talboo, C Grommes, CYD Lee, G Landreth Journal of Biological Chemistry 281 (30), 20842-20850, 2006 | 158 | 2006 |
Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi-and NF-κB-dependent mechanism H Lee, CI Lin, JJ Liao, YW Lee, HY Yang, CY Lee, HY Hsu, HL Wu American Journal of Physiology-Cell Physiology 287 (6), C1657-C1666, 2004 | 113 | 2004 |
N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice X Gu, JP Cantle, ER Greiner, CYD Lee, AM Barth, F Gao, CS Park, ... Neuron 85 (4), 726-741, 2015 | 81 | 2015 |
Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis CY Lee, JP Cantle, XW Yang The FEBS journal 280 (18), 4382-4394, 2013 | 69 | 2013 |
Exposure of myeloid dendritic cells to exogenous or endogenous IL-10 during maturation determines their longevity WLW Chang, N Baumgarth, MK Eberhardt, CYD Lee, CA Baron, JP Gregg, ... The Journal of Immunology 178 (12), 7794-7804, 2007 | 69 | 2007 |
Proliferation of a subpopulation of reactive astrocytes following needle-insertion lesion in rat CY Lee, GD Pappas, V Kriho, BM Huang, HY Yang Neurological research 25 (7), 767-776, 2003 | 18 | 2003 |
Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington’s disease patients CYD Lee, N Wang, K Shen, M Stricos, P Langfelder, KH Cheon, ... Scientific reports 10 (1), 1-14, 2020 | 13 | 2020 |
Huntington's Disease: Genome-wide Neuroprotection Screening Goes Viral CYD Lee, XW Yang Neuron 106 (1), 4-6, 2020 | 1 | 2020 |