| Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770 F Van Goor, S Hadida, PDJ Grootenhuis, B Burton, D Cao, T Neuberger, ... Proceedings of the National Academy of Sciences 106 (44), 18825-18830, 2009 | 1363 | 2009 |
| Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809 F Van Goor, S Hadida, PDJ Grootenhuis, B Burton, JH Stack, KS Straley, ... Proceedings of the National Academy of Sciences 108 (46), 18843-18848, 2011 | 1226 | 2011 |
| Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs J Kelder, PDJ Grootenhuis, DM Bayada, LPC Delbressine, JP Ploemen Pharmaceutical research 16, 1514-1519, 1999 | 982 | 1999 |
| Rescue of ΔF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules F Van Goor, KS Straley, D Cao, J González, S Hadida, A Hazlewood, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 290 (6 …, 2006 | 652 | 2006 |
| The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions HA Schreuder, B de Boer, R Dijkema, J Mulders, HJM Theunissen, ... Nature structural biology 1 (1), 48-54, 1994 | 360 | 1994 |
| Computational study of the structural, energetic, and acid-base properties of calix [4] arenes PDJ Grootenhuis, PA Kollman, LC Groenen, DN Reinhoudt, ... Journal of the American Chemical Society 112 (11), 4165-4176, 1990 | 357 | 1990 |
| Modulators of ATP-binding cassette transporters S Hadida-Ruah, M Hamilton, M Miller, PDJ Grootenhuis, B Bear, ... US Patent 7,659,268, 2010 | 226* | 2010 |
| A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein JE Penzotti, ML Lamb, E Evensen, PDJ Grootenhuis Journal of medicinal chemistry 45 (9), 1737-1740, 2002 | 223 | 2002 |
| Pyridyl derivatives as CFTR modulators S Hadida-Ruah, M Miller, J Zhou, B Bear, P Grootenhuis US Patent 8,227,615, 2012 | 202 | 2012 |
| Modulators of ATP-binding cassette transporters S Hadida-Ruah, A Hazelwood, P Grootenhuis, F Van Goor, A Singh, ... US Patent 7,495,103, 2009 | 202 | 2009 |
| Modulators of ATP-binding cassette transporters LR Makings, AK Singh, MT Miller, SSH Ruah, PDJ Grootenhuis, ... US Patent 8,642,609, 2014 | 194 | 2014 |
| Modulators of ATP-Binding Cassette transporters SSH Ruah, MT Miller, AK Singh, T Cleveland, LR Makings, M Hamilton, ... US Patent 7,973,169, 2011 | 173* | 2011 |
| Modulators of CFTR SSH Ruah, M Miller, B Bear, J Zhou, J McCartney, P Grootenhuis US Patent 7,754,739, 2010 | 154 | 2010 |
| Indole derivatives as CFTR modulators SSH Ruah, PDJ Grootenhuis, F Van Goor, J Zhou, B Bear, MT Miller, ... US Patent 7,645,789, 2010 | 150 | 2010 |
| Modulators of ATP-binding cassette transporters F Van Goor US Patent 8,354,427, 2013 | 148 | 2013 |
| Molecular mechanics and dynamics studies of crown ether-cation interactions: free energy calculations on the cation selectivity of dibenzo-18-crown-6 and dibenzo-30-crown-10 PDJ Grootenhuis, PA Kollman Journal of the American Chemical Society 111 (6), 2152-2158, 1989 | 145 | 1989 |
| Solid forms of N-(4-(7-azabicyclo [2.2. 1] heptan-7-yl)-2-(trifluorormethyl) phenyl)-4-oxo-5-(trifluoromethyl)-1, 4-dihyroquinoline-3-carboxamide B Zhang, M Krawiec, M Botfield, PDJ Grootenhuis, F Van Goor US Patent 8,436,014, 2013 | 142 | 2013 |
| Constructing a molecular model of the interaction between antithrombin III and a potent heparin analog PDJ Grootenhuis, CAA Van Boeckel Journal of the American Chemical Society 113 (7), 2743-2747, 1991 | 137 | 1991 |
| Modulators of ATP-binding cassette transporters S Hadida-Ruah, A Hazlewood, P Grootenhuis, F Van Goor, A Singh, ... US Patent 8,829,204, 2014 | 135 | 2014 |
| Process for making modulators of cystic fibrosis transmembrane conductance regulator J DeMattei, AR Looker, B Neubert-Langille, M Trudeau, S Roeper, ... US Patent 8,476,442, 2013 | 135 | 2013 |
