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Simon Hansen
Simon Hansen
NGM Biotherapeutics
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Zitiert von
Zitiert von
Jahr
Protein interference applications in cellular and developmental biology using DARPins that recognize GFP and mCherry
M Brauchle, S Hansen, E Caussinus, A Lenard, A Ochoa-Espinosa, ...
Biology open 3 (12), 1252-1261, 2014
812014
Designed Armadillo repeat proteins: library generation, characterization and selection of peptide binders with high specificity
G Varadamsetty, D Tremmel, S Hansen, F Parmeggiani, A Plückthun
Journal of molecular biology 424 (1-2), 68-87, 2012
712012
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells
AH Nile, F de Sousa e Melo, S Mukund, R Piskol, S Hansen, L Zhou, ...
Nature chemical biology 14 (6), 582-590, 2018
642018
Modular peptide binding: from a comparison of natural binders to designed armadillo repeat proteins
C Reichen, S Hansen, A Plückthun
Journal of structural biology 185 (2), 147-162, 2014
622014
Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity
S Hansen, JC Stüber, P Ernst, A Koch, D Bojar, A Batyuk, A Plückthun
Scientific reports 7 (1), 16292, 2017
552017
Structure and energetic contributions of a designed modular peptide-binding protein with picomolar affinity
S Hansen, D Tremmel, C Madhurantakam, C Reichen, PRE Mittl, ...
Journal of the American Chemical Society 138 (10), 3526-3532, 2016
312016
Computationally designed armadillo repeat proteins for modular peptide recognition
C Reichen, S Hansen, C Forzani, A Honegger, SJ Fleishman, T Zhou, ...
Journal of molecular biology 428 (22), 4467-4489, 2016
222016
Design of an autonomous cooperative drone swarm for inspections of safety critical infrastructure
RH Jacobsen, L Matlekovic, L Shi, N Malle, N Ayoub, K Hageman, ...
Applied Sciences 13 (3), 1256, 2023
212023
G-quadruplexes are specifically recognized and distinguished by selected designed ankyrin repeat proteins
O Scholz, S Hansen, A Plückthun
Nucleic acids research 42 (14), 9182-9194, 2014
202014
Nanobody-driven signaling reveals the core receptor complex in root nodule symbiosis
H Rübsam, C Krönauer, NB Abel, H Ji, D Lironi, SB Hansen, M Nadzieja, ...
Science 379 (6629), 272-277, 2023
142023
Curvature of designed armadillo repeat proteins allows modular peptide binding
S Hansen, P Ernst, SLB König, C Reichen, C Ewald, D Nettels, PRE Mittl, ...
Journal of structural biology 201 (2), 108-117, 2018
142018
Structures of designed armadillo repeat proteins binding to peptides fused to globular domains
S Hansen, JD Kiefer, C Madhurantakam, PRE Mittl, A Plückthun
Protein Science 26 (10), 1942-1952, 2017
132017
Structure of the Wnt–Frizzled–LRP6 initiation complex reveals the basis for coreceptor discrimination
N Tsutsumi, S Hwang, D Waghray, S Hansen, KM Jude, N Wang, Y Miao, ...
Proceedings of the National Academy of Sciences 120 (11), e2218238120, 2023
112023
Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling
S Hansen, Y Zhang, S Hwang, A Nabhan, W Li, J Fuhrmann, ...
Proceedings of the National Academy of Sciences 119 (46), e2207327119, 2022
112022
Individual differences in learning during decision-making may predict specific harms associated with gambling
N Kildahl, S Hansen, D Brevers, J Skewes
Addictive behaviors 110, 106496, 2020
112020
Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects
C Reichen, C Madhurantakam, S Hansen, MG Grütter, A Plückthun, ...
Acta Crystallographica Section D: Structural Biology 72 (1), 168-175, 2016
112016
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling
J Yun, S Hansen, O Morris, DT Madden, CP Libeu, AJ Kumar, C Wehrfritz, ...
Nature Communications 14 (1), 156, 2023
92023
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
N Friedrich, E Stiegeler, M Glögl, T Lemmin, S Hansen, C Kadelka, Y Wu, ...
Nature Communications 12 (1), 6705, 2021
92021
Lead Optimization Yields High Affinity Frizzled 7-Targeting Peptides That Modulate Clostridium difficile Toxin B Pathogenicity in Epithelial Cells
S Hansen, AH Nile, SC Mehta, J Fuhrmann, RN Hannoush
Journal of Medicinal Chemistry 62 (17), 7739-7750, 2019
82019
A glycan receptor kinase facilitates intracellular accommodation of arbuscular mycorrhiza and symbiotic rhizobia in the legume Lotus japonicus
S Kelly, SB Hansen, H Rübsam, P Saake, EB Pedersen, K Gysel, ...
PLoS Biology 21 (5), e3002127, 2023
72023
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