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Rahul S Samant
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Mechanisms and functions of spatial protein quality control
EM Sontag, RS Samant, J Frydman
Annual review of biochemistry 86, 97-122, 2017
2642017
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system
S Polier, RS Samant, PA Clarke, P Workman, C Prodromou, LH Pearl
Nature chemical biology 9 (5), 307-312, 2013
1642013
Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control
RS Samant, CM Livingston, EM Sontag, J Frydman
Nature 563 (7731), 407-411, 2018
1572018
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease
T Dale, PA Clarke, C Esdar, D Waalboer, O Adeniji-Popoola, ...
Nature chemical biology 11 (12), 973, 2015
1312015
Alternative systems for misfolded protein clearance: life beyond the proteasome
HE Johnston, RS Samant
The FEBS journal 288 (15), 4464-4487, 2021
702021
E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells
RS Samant, PA Clarke, P Workman
Proceedings of the National Academy of Sciences 111 (18), 6834-6839, 2014
622014
The expanding proteome of the molecular chaperone HSP90
RS Samant, PA Clarke, P Workman
Cell cycle 11 (7), 1301-1308, 2012
382012
Solvent precipitation SP3 (SP4) enhances recovery for proteomics sample preparation without magnetic beads
HE Johnston, K Yadav, JM Kirkpatrick, GS Biggs, D Oxley, HB Kramer, ...
Analytical Chemistry 94 (29), 10320-10328, 2022
272022
Native mass spectrometry analyses of chaperonin complex TRiC/CCT reveal subunit N-terminal processing and re-association patterns
MP Collier, KB Moreira, KH Li, YC Chen, D Itzhak, R Samant, A Leitner, ...
Scientific Reports 11 (1), 13084, 2021
132021
Choose your protein partners
RS Samant, P Workman
Nature 490 (7420), 351-352, 2012
122012
Methods for measuring misfolded protein clearance in the budding yeast Saccharomyces cerevisiae
RS Samant, J Frydman
Methods in enzymology 619, 27-45, 2019
72019
Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy
RS Samant, VB Masto, J Frydman
Genes & Development 33 (15-16), 1027-1030, 2019
22019
Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potential
P Clarke, C Esdar, A Mallinger, K Schiemann, D Waalboer, S Crumpler, ...
Cancer Research 76 (14_Supplement), 3025-3025, 2016
22016
A hierarchical assembly pathway directs the unique subunit arrangement of TRiC/CCT
KB Moreira, MP Collier, A Leitner, KH Li, ILS Lachapel, F McCarthy, ...
Molecular Cell 83 (17), 3123-3139. e8, 2023
12023
Native Size-Exclusion Chromatography–Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes
RS Samant, S Batista, M Larance, B Ozer, CI Milton, I Bludau, E Wu, ...
Molecular & Cellular Proteomics 22 (2), 2023
12023
Native size exclusion chromatography-based mass spectrometry (SEC-MS) identifies novel components of the Heat Shock Protein 90-dependent proteome
RS Samant, S Batista, M Larance, B Ozer, CI Milton, I Bludau, L Biggins, ...
BioRxiv, 2022.05. 23.492985, 2022
12022
Introduction: Molecular Chaperones and Protein Quality Control
D Balchin, MA Rangel, RS Samant
2023
INTERPLAY BETWEEN LOSS OF PROTEOSTASIS AND CELLULAR SENESCENCE: A SPOTLIGHT ON MISFOLDED PROTEIN QUALITY CONTROL
R Samant
Innovation in Aging 6 (Suppl 1), 424, 2022
2022
Dysregulated proteostasis: mechanisms and links to aging
Y Al-Muftia, S Cranwella, RS Samant
Molecular, Cellular, and Metabolic Fundamentals of Human Aging, 55, 2022
2022
Size exclusion chromatography-based proteomics to identify novel components of the HSP90-dependent proteome following pharmacologic inhibition in colon cancer cells
RS Samant, S Aires-Batista, B Ozer, M Larance, C McAndrew, ...
MOLECULAR & CELLULAR PROTEOMICS 18 (8), S59-S59, 2019
2019
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