| Mechanisms and functions of spatial protein quality control EM Sontag, RS Samant, J Frydman Annual review of biochemistry 86, 97-122, 2017 | 264 | 2017 |
| Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo J Legleiter, E Mitchell, GP Lotz, E Sapp, C Ng, M DiFiglia, LM Thompson, ... Journal of Biological Chemistry 285 (19), 14777-14790, 2010 | 241 | 2010 |
| Identifying polyglutamine protein species in situ that best predict neurodegeneration J Miller, M Arrasate, E Brooks, CP Libeu, J Legleiter, D Hatters, J Curtis, ... Nature chemical biology 7 (12), 925-934, 2011 | 232 | 2011 |
| Sorting out the trash: the spatial nature of eukaryotic protein quality control EM Sontag, WIM Vonk, J Frydman Current opinion in cell biology 26, 139-146, 2014 | 176 | 2014 |
| Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control RS Samant, CM Livingston, EM Sontag, J Frydman Nature 563 (7731), 407-411, 2018 | 157 | 2018 |
| A transgenic minipig model of Huntington's Disease M Baxa, M Hruska-Plochan, S Juhas, P Vodicka, A Pavlok, J Juhasova, ... Journal of Huntington's disease 2 (1), 47-68, 2013 | 149 | 2013 |
| Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models EM Sontag, GP Lotz, N Agrawal, A Tran, R Aron, G Yang, M Necula, ... Journal of Neuroscience 32 (32), 11109-11119, 2012 | 123 | 2012 |
| Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle GP Lotz, J Legleiter, R Aron, EJ Mitchell, SY Huang, C Ng, C Glabe, ... Journal of biological chemistry 285 (49), 38183-38193, 2010 | 99 | 2010 |
| Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes EM Sontag, LA Joachimiak, Z Tan, A Tomlinson, DE Housman, CG Glabe, ... Proceedings of the National Academy of Sciences 110 (8), 3077-3082, 2013 | 84 | 2013 |
| Huntington’s disease cerebrospinal fluid seeds aggregation of mutant huntingtin Z Tan, W Dai, TGM van Erp, J Overman, A Demuro, MA Digman, A Hatami, ... Molecular psychiatry 20 (11), 1286-1293, 2015 | 70 | 2015 |
| Multi-scale 3D cryo-correlative microscopy for vitrified cells GH Wu, PG Mitchell, JG Galaz-Montoya, CW Hecksel, EM Sontag, ... Structure 28 (11), 1231-1237. e3, 2020 | 65 | 2020 |
| Detection of mutant huntingtin aggregation conformers and modulation of SDS-soluble fibrillar oligomers by small molecules EM Sontag, GP Lotz, G Yang, CJ Sontag, BJ Cummings, CG Glabe, ... Journal of Huntington's disease 1 (1), 119-132, 2012 | 38 | 2012 |
| Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT EM Sontag, F Morales-Polanco, JH Chen, G McDermott, PT Dolan, ... Nature Cell Biology 25 (5), 699-713, 2023 | 16 | 2023 |
| Phase separation in biology and disease; current perspectives and open questions S Boeynaems, S Chong, J Gsponer, L Holt, D Milovanovic, DM Mitrea, ... Journal of molecular biology 435 (5), 167971, 2023 | 15 | 2023 |
| Spatial sequestration of misfolded proteins in neurodegenerative diseases S Rolli, EM Sontag Biochemical Society Transactions 50 (2), 759-771, 2022 | 4 | 2022 |
| An ESCRT-dependent pathway coordinates Nuclear and Cytoplasmic Spatial Protein Quality Control at Nuclear Vacuolar Junctions EM Sontag, F Morales-Polanco, JH Chen, G McDermott, PT Dolan, ... bioRxiv, 2022 | 1 | 2022 |
| Sorting Out the JUNQ: the Spatial Nature of Protein Quality Control E Sontag, JH Chen, G McDermott, D Gestaut, C Larabell, J Frydman Microscopy and Microanalysis 23 (S1), 994-995, 2017 | 1 | 2017 |
| Stress Biology: Complexity and Multifariousness in Health and Disease MP Mayer, L Blair, GL Blatch, TJ Borges, A Chadli, G Chiosis, A de Thonel, ... Cell Stress and Chaperones, 2024 | | 2024 |
| Clearance of Nuclear and Cytosolic Aggregates at Nuclear‐Vacuolar Junctions E Sontag, JH Chen, G McDermott, P Dolan, D Gestaut, M LeGros, ... The FASEB Journal 35, 2021 | | 2021 |
| Detection of Aggregation Intermediates as Targets for Huntington's Disease Therapeutics EJ Mitchell University of California, Irvine, 2011 | | 2011 |
Judith FrydmanStanford UniversityVerified email at stanford.edu
