Therapeutic uses of furin and its inhibitors: a patent review F Couture, A Kwiatkowska, YL Dory, R Day Expert opinion on therapeutic patents 25 (4), 379-396, 2015 | 86 | 2015 |
On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications F Couture, F D'Anjou, R Day Walter de Gruyter 2 (5), 421-438, 2011 | 79 | 2011 |
Role of proprotein convertases in prostate cancer progression F Couture, F D'Anjou, R Desjardins, F Boudreau, R Day Neoplasia 14 (11), 1032-IN6, 2012 | 68 | 2012 |
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells C Levesque, M Fugère, A Kwiatkowska, F Couture, R Desjardins, ... Journal of Medicinal Chemistry 55 (23), 10501-10511, 2012 | 57 | 2012 |
PACE4 undergoes an oncogenic alternative splicing switch in cancer F Couture, R Sabbagh, A Kwiatkowska, R Desjardins, SP Guay, ... Cancer Research 77 (24), 6863-6879, 2017 | 50 | 2017 |
Design, synthesis, and structure–activity relationship studies of a potent PACE4 inhibitor A Kwiatkowska, F Couture, C Levesque, K Ly, R Desjardins, ... Journal of medicinal chemistry 57 (1), 98-109, 2014 | 42 | 2014 |
PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction increased apoptosis and impaired neovascularisation. C Levesque, F Couture, A Kwiatkowska, R Desjardins, B Guérin, ... Oncotarget, 2015 | 37 | 2015 |
Implications of proprotein convertases in ovarian cancer cell proliferation and tumor progression: insights for PACE4 as a therapeutic target R Longuespée, F Couture, C Levesque, A Kwiatkowska, R Desjardins, ... Translational Oncology 7 (3), 410-419, 2014 | 37 | 2014 |
Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin H Gagnon, S Beauchemin, A Kwiatkowska, F Couture, F D’Anjou, ... Journal of Medicinal Chemistry 57 (1), 29-41, 2014 | 36 | 2014 |
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression F Panet, F Couture, A Kwiatkowska, R Desjardins, B Guérin, R Day European journal of cell biology 96 (5), 469-475, 2017 | 24 | 2017 |
Gastrointestinal stability and cytotoxicity of bacteriocins from Gram-positive and Gram-negative bacteria: a comparative in vitro study S Soltani, S Zirah, S Rebuffat, F Couture, Y Boutin, E Biron, M Subirade, ... Frontiers in Microbiology 12, 780355, 2022 | 20 | 2022 |
V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss AH Mohammad, S Assadian, F Couture, KJ Lefebvre, W El-Assaad, ... Oncotarget 10 (48), 4923, 2019 | 20 | 2019 |
PACE4-based molecular targeting of prostate cancer using an engineered 64Cu-radiolabeled peptide inhibitor F Couture, C Levesque, V Dumulon-Perreault, S Ait-Mohand, F D’Anjou, ... Neoplasia 16 (8), 634-643, 2014 | 18 | 2014 |
A Naked Eye‐Invisible Ratiometric Fluorescent Microneedle Tattoo for Real‐Time Monitoring of Inflammatory Skin Conditions S Babity, F Couture, EVR Campos, S Hedtrich, R Hagen, D Fehr, ... Advanced Healthcare Materials 11 (6), 2102070, 2022 | 16 | 2022 |
In vitro investigation of gastrointestinal stability and toxicity of 3-hyrdoxypropionaldehyde (reuterin) produced by Lactobacillus reuteri S Soltani, F Couture, Y Boutin, LB Said, S Cashman-Kadri, M Subirade, ... Toxicology Reports 8, 740-746, 2021 | 16 | 2021 |
Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function S Babity, AK Polomska, F Couture, M Bonmarin, D Fehr, M Detmar, ... Journal of controlled release 327, 350-359, 2020 | 16 | 2020 |
Novel Insights into Structure–Activity Relationships of N‐Terminally Modified PACE4 Inhibitors A Kwiatkowska, F Couture, C Levesque, K Ly, S Beauchemin, ... ChemMedChem 11 (3), 289-301, 2016 | 16 | 2016 |
Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells F D’Anjou, F Couture, R Desjardins, R Day Therapeutic Applications of Ribozymes and Riboswitches: Methods and …, 2014 | 13 | 2014 |
Evaluation of PACE4 isoforms as biomarkers in thyroid cancer L Fradet, R Temmar, F Couture, M Belzile, PH Fortier, R Day Journal of Otolaryngology-Head & Neck Surgery 47 (1), 63, 2018 | 12 | 2018 |
Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug A Kwiatkowska, F Couture, S Ait-Mohand, R Desjardins, YL Dory, ... Scientific Reports 9 (1), 2118, 2019 | 10 | 2019 |