| Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis S Bunda, K Burrell, P Heir, L Zeng, A Alamsahebpour, Y Kano, B Raught, ... Nature communications 6 (1), 8859, 2015 | 230 | 2015 |
| Small molecule tools for functional interrogation of protein tyrosine phosphatases R He, LF Zeng, Y He, S Zhang, ZY Zhang The FEBS journal 280 (2), 731-750, 2013 | 150 | 2013 |
| Therapeutic potential of targeting the oncogenic SHP2 phosphatase LF Zeng, RY Zhang, ZH Yu, S Li, L Wu, AM Gunawan, BS Lane, RS Mali, ... Journal of medicinal chemistry 57 (15), 6594-6609, 2014 | 127 | 2014 |
| Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors S Liu, LF Zeng, L Wu, X Yu, T Xue, AM Gunawan, YQ Long, ZY Zhang Journal of the American Chemical Society 130 (50), 17075-17084, 2008 | 93 | 2008 |
| Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus J Wang, M Mizui, LF Zeng, R Bronson, M Finnell, C Terhorst, VC Kyttaris, ... The Journal of clinical investigation 126 (6), 2077-2092, 2016 | 76 | 2016 |
| Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups X Fan, FH Zhang, RI Al-Safi, LF Zeng, Y Shabaik, B Debnath, ... Bioorganic & medicinal chemistry 19 (16), 4935-4952, 2011 | 68 | 2011 |
| Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1, 6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties LF Zeng, Y Wang, R Kazemi, S Xu, ZL Xu, TW Sanchez, LM Yang, ... Journal of Medicinal Chemistry 55 (22), 9492-9509, 2012 | 62 | 2012 |
| Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors LF Zeng, HS Zhang, YH Wang, T Sanchez, YT Zheng, N Neamati, ... Bioorganic & medicinal chemistry letters 18 (16), 4521-4524, 2008 | 62 | 2008 |
| SHP2 phosphatase as a novel therapeutic target for melanoma treatment RY Zhang, ZH Yu, L Zeng, S Zhang, Y Bai, J Miao, L Chen, J Xie, ... Oncotarget 7 (45), 73817, 2016 | 57 | 2016 |
| Exploring the existing drug space for novel pTyr mimetic and SHP2 inhibitors R He, ZH Yu, RY Zhang, L Wu, AM Gunawan, BS Lane, JS Shim, LF Zeng, ... ACS medicinal chemistry letters 6 (7), 782-786, 2015 | 57 | 2015 |
| Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT RS Mali, P Ma, LF Zeng, H Martin, B Ramdas, Y He, E Sims, S Nabinger, ... Blood, The Journal of the American Society of Hematology 120 (13), 2669-2678, 2012 | 57 | 2012 |
| Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation K Maeshima, SM Stanford, D Hammaker, C Sacchetti, L Zeng, R Ai, ... JCI insight 1 (7), 2016 | 53 | 2016 |
| The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo SC Nabinger, XJ Li, B Ramdas, Y He, X Zhang, L Zeng, B Richine, ... Leukemia 27 (2), 398-408, 2013 | 53 | 2013 |
| Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase Y Bai, ZH Yu, S Liu, L Zhang, RY Zhang, LF Zeng, S Zhang, ZY Zhang Cancer research 76 (16), 4805-4815, 2016 | 51 | 2016 |
| Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma J Xu, LF Zeng, W Shen, JJ Turchi, ZY Zhang Biochemical and biophysical research communications 439 (4), 586-590, 2013 | 46 | 2013 |
| Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers L Prabhu, H Wei, L Chen, Ö Demir, G Sandusky, E Sun, J Wang, J Mo, ... Oncotarget 8 (25), 39963, 2017 | 43 | 2017 |
| Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors Y He, LF Zeng, ZH Yu, R He, S Liu, ZY Zhang Bioorganic & medicinal chemistry 20 (6), 1940-1946, 2012 | 40 | 2012 |
| Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases L Prabhu, L Chen, H Wei, Ö Demir, A Safa, L Zeng, RE Amaro, BH O’Neil, ... Molecular biosystems 13 (12), 2509-2520, 2017 | 36 | 2017 |
| Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: Effects of the phenyl substituent and the linker orientation LF Zeng, XH Jiang, T Sanchez, HS Zhang, R Dayam, N Neamati, ... Bioorganic & medicinal chemistry 16 (16), 7777-7787, 2008 | 36 | 2008 |
| Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitor R He, Z Yu, Y He, LF Zeng, J Xu, L Wu, AM Gunawan, L Wang, ZX Jiang, ... ChemMedChem 5 (12), 2051-2056, 2010 | 30 | 2010 |
Peilin MaResearch InvestigatorVerified email at umich.edu
