| The aldo-keto reductase superfamily: cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases KM Bohren, B Bullock, B Wermuth, KH Gabbay Journal of Biological Chemistry 264 (16), 9547-9551, 1989 | 561 | 1989 |
| An unlikely sugar substrate site in the 1.65 Å structure of the human aldose reductase holoenzyme implicated in diabetic complications DK Wilson, KM Bohren, KH Gabbay, FA Quiocho Science 257 (5066), 81-84, 1992 | 560 | 1992 |
| A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus KM Bohren, V Nadkarni, JH Song, KH Gabbay, D Owerbach Journal of Biological Chemistry 279 (26), 27233-27238, 2004 | 517 | 2004 |
| A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation D Owerbach, EM McKay, ETH Yeh, KH Gabbay, KM Bohren Biochemical and biophysical research communications 337 (2), 517-520, 2005 | 317 | 2005 |
| Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene BCB Ko, B Ruepp, KM Bohren, KH Gabbay, SSM Chung Journal of Biological Chemistry 272 (26), 16431-16437, 1997 | 243 | 1997 |
| Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal … KM Bohren, CE Grimshaw, CJ Lai, DH Harrison, D Ringe, GA Petsko, ... Biochemistry 33 (8), 2021-2032, 1994 | 234 | 1994 |
| An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate DH Harrison, KM Bohren, D Ringe, GA Petsko, KH Gabbay Biochemistry 33 (8), 2011-2020, 1994 | 186 | 1994 |
| Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein. B Wermuth, KM Bohren, G Heinemann, JP von Wartburg, KH Gabbay Journal of biological chemistry 263 (31), 16185-16188, 1988 | 178 | 1988 |
| Mechanism of human aldehyde reductase: characterization of the active site pocket OA Barski, KH Gabbay, CE Grimshaw, KM Bohren Biochemistry 34 (35), 11264-11275, 1995 | 160 | 1995 |
| Purification and characterization of human‐brain aldose reductase B Wermuth, H Bürgisser, K Bohren, JP Von Wartburg European journal of biochemistry 127 (2), 279-284, 1982 | 160 | 1982 |
| Human aldose reductase: rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme CE Grimshaw, KM Bohren, CJ Lai, KH Gabbay Biochemistry 34 (44), 14356-14365, 1995 | 138 | 1995 |
| Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis KH Gabbay, KM Bohren, R Morello, T Bertin, J Liu, P Vogel Journal of biological chemistry 285 (25), 19510-19520, 2010 | 129 | 2010 |
| Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262. KM Bohren, JL Page, R Shankar, SP Henry, KH Gabbay Journal of Biological Chemistry 266 (35), 24031-24037, 1991 | 123 | 1991 |
| Osmotic response element enhancer activity: Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase V Nadkarni, KH Gabbay, KM Bohren, D Sheikh-Hamad Journal of Biological Chemistry 274 (29), 20185-20190, 1999 | 102 | 1999 |
| Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors T Ehrig, KM Bohren, FG Prendergast, KH Gabbay Biochemistry 33 (23), 7157-7165, 1994 | 102 | 1994 |
| Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain. KM Bohren, CE Grimshaw, KH Gabbay Journal of Biological Chemistry 267 (29), 20965-20970, 1992 | 99 | 1992 |
| Characterization of the human aldose reductase gene promoter K Wang, KM Bohren, KH Gabbay Journal of Biological Chemistry 268 (21), 16052-16058, 1993 | 90 | 1993 |
| Characterization of the osmotic response element of the human aldose reductase gene promoter. B Ruepp, KM Bohren, KH Gabbay Proceedings of the National Academy of Sciences 93 (16), 8624-8629, 1996 | 86 | 1996 |
| The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant DHT Harrison, KM Bohren, GA Petsko, D Ringe, KH Gabbay Biochemistry 36 (51), 16134-16140, 1997 | 74 | 1997 |
| The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity OA Barski, KH Gabbay, KM Bohren Biochemistry 35 (45), 14276-14280, 1996 | 73 | 1996 |
