| Most efficient cocaine hydrolase designed by virtual screening of transition states F Zheng, W Yang, MC Ko, J Liu, H Cho, D Gao, M Tong, HH Tai, ... Journal of the American Chemical Society 130 (36), 12148-12155, 2008 | 200 | 2008 |
| The role of central μ opioid receptors in opioid-induced itch in primates MCH Ko, MS Song, T Edwards, H Lee, NN Naughton Journal of Pharmacology and Experimental Therapeutics 310 (1), 169-176, 2004 | 181 | 2004 |
| An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception MCH Ko, NN Naughton The Journal of the American Society of Anesthesiologists 92 (3), 795-805, 2000 | 134 | 2000 |
| Activation of κ-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys MCH Ko, H Lee, MS Song, K Sobczyk-Kojiro, HI Mosberg, S Kishioka, ... Journal of Pharmacology and Experimental Therapeutics 305 (1), 173-179, 2003 | 129 | 2003 |
| How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches. T Biro, MC Ko, B Bromm, ET Wei, JG Meingassner Experimental dermatology 14 (3), 234-235, 2005 | 126 | 2005 |
| A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates H Ding, N Kiguchi, D Yasuda, PR Daga, WE Polgar, JJ Lu, PW Czoty, ... Science translational medicine 10 (456), eaar3483, 2018 | 125 | 2018 |
| Functional plasticity of the N/OFQ‐NOP receptor system determines analgesic properties of NOP receptor agonists W Schröder, DG Lambert, MC Ko, T Koch British journal of pharmacology 171, 3777-3800, 2014 | 122 | 2014 |
| STING controls nociception via type I interferon signalling in sensory neurons CR Donnelly, C Jiang, AS Andriessen, K Wang, Z Wang, H Ding, J Zhao, ... Nature 591 (7849), 275-280, 2021 | 121 | 2021 |
| Relative reinforcing effects of three opioids with different durations of action MC Ko, J Terner, S Hursh, JH Woods, G Winger Journal of Pharmacology and Experimental Therapeutics 301 (2), 698-704, 2002 | 112 | 2002 |
| Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine L Xue, MC Ko, M Tong, W Yang, S Hou, L Fang, J Liu, F Zheng, JH Woods, ... Molecular pharmacology 79 (2), 290-297, 2011 | 107 | 2011 |
| A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates H Ding, PW Czoty, N Kiguchi, G Cami-Kobeci, DD Sukhtankar, MA Nader, ... Proceedings of the National Academy of Sciences 113 (37), E5511-E5518, 2016 | 106 | 2016 |
| Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity D Gao, DL Narasimhan, J Macdonald, R Brim, MC Ko, DW Landry, ... Molecular pharmacology 75 (2), 318-323, 2009 | 106 | 2009 |
| Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates CM Cremeans, E Gruley, DJ Kyle, MC Ko Journal of Pharmacology and Experimental Therapeutics 343 (1), 72-81, 2012 | 105 | 2012 |
| Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys MC Ko, JH Woods, WE Fantegrossi, CM Galuska, J Wichmann, ... Neuropsychopharmacology 34 (9), 2088-2096, 2009 | 99 | 2009 |
| Effects of atypical κ-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates MC Ko, SM Husbands Journal of Pharmacology and Experimental Therapeutics 328 (1), 193-200, 2009 | 97 | 2009 |
| Endogenous opioids upregulate brain‐derived neurotrophic factor mRNA through δ‐and µ‐opioid receptors independent of antidepressant‐like effects H Zhang, MM Torregrossa, EM Jutkiewicz, YG Shi, KC Rice, JH Woods, ... European Journal of Neuroscience 23 (4), 984-994, 2006 | 96 | 2006 |
| Central κ-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: Behavioral and BDNF mRNA expression studies H Zhang, YG Shi, JH Woods, SJ Watson, MC Ko European journal of pharmacology 570 (1-3), 89-96, 2007 | 95 | 2007 |
| Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys MC Ko, NN Naughton The journal of pain 10 (5), 509-516, 2009 | 88 | 2009 |
| Local administration of Δ9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid action MC Ko, JH Woods Psychopharmacology 143, 322-326, 1999 | 88 | 1999 |
| Periostin activation of integrin receptors on sensory neurons induces allergic itch SK Mishra, JJ Wheeler, S Pitake, H Ding, C Jiang, T Fukuyama, JS Paps, ... Cell reports 31 (1), 2020 | 87 | 2020 |
Norikazu KiguchiDepartment of Physiological Sciences, School of Pharmaceutical Sciences, Wakayama Medical UniversityVerified email at wakayama-med.ac.jp
