Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F R Cencic, DR Hall, F Robert, Y Du, J Min, L Li, M Qui, I Lewis, S Kurtkaya, ... Proceedings of the National Academy of Sciences 108 (3), 1046-1051, 2011 | 209 | 2011 |
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F R Cencic, DR Hall, F Robert, Y Du, J Min, L Li, M Qui, I Lewis, S Kurtkaya, ... Proceedings of the National Academy of Sciences 108 (3), 1046-1051, 2011 | 209 | 2011 |
The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies Z Li, AA Ivanov, R Su, V Gonzalez-Pecchi, Q Qi, S Liu, P Webber, ... Nature communications 8 (1), 14356, 2017 | 203 | 2017 |
14-3-3 proteins as potential therapeutic targets J Zhao, CL Meyerkord, Y Du, FR Khuri, H Fu Seminars in cell & developmental biology 22 (7), 705-712, 2011 | 190 | 2011 |
Inhibition of IκB kinase-nuclear factor-κB signaling pathway by 3, 5-bis (2-flurobenzylidene) piperidin-4-one (EF24), a novel monoketone analog of curcumin AL Kasinski, Y Du, SL Thomas, J Zhao, SY Sun, FR Khuri, CY Wang, ... Molecular pharmacology 74 (3), 654-661, 2008 | 182 | 2008 |
Down-regulation of 14-3-3ζ suppresses anchorage-independent growth of lung cancer cells through anoikis activation Z Li, J Zhao, Y Du, HR Park, SY Sun, L Bernal-Mizrachi, A Aitken, ... Proceedings of the National Academy of Sciences 105 (1), 162-167, 2008 | 179 | 2008 |
An expanded universe of cancer targets WC Hahn, JS Bader, TP Braun, A Califano, PA Clemons, BJ Druker, ... Cell 184 (5), 1142-1155, 2021 | 153 | 2021 |
Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway X Qiu, Y Du, B Lou, Y Zuo, W Shao, Y Huo, J Huang, Y Yu, B Zhou, J Du, ... Journal of medicinal chemistry 53 (23), 8260-8273, 2010 | 132 | 2010 |
Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication R Cencic, M Desforges, DR Hall, D Kozakov, Y Du, J Min, R Dingledine, ... Journal of virology 85 (13), 6381-6389, 2011 | 127 | 2011 |
Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2 J Jiang, T Ganesh, Y Du, Y Quan, G Serrano, M Qui, I Speigel, A Rojas, ... Proceedings of the National Academy of Sciences 109 (8), 3149-3154, 2012 | 126 | 2012 |
Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits SME Smith, J Min, T Ganesh, B Diebold, T Kawahara, Y Zhu, J McCoy, ... Chemistry & biology 19 (6), 752-763, 2012 | 125 | 2012 |
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease Z Zhang, O Obianyo, E Dall, Y Du, H Fu, X Liu, SS Kang, M Song, SP Yu, ... Nature communications 8 (1), 14740, 2017 | 120 | 2017 |
Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor J Zhao, Y Du, JR Horton, AK Upadhyay, B Lou, Y Bai, X Zhang, L Du, M Li, ... Proceedings of the National Academy of Sciences 108 (39), 16212-16216, 2011 | 118 | 2011 |
Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma K Liu, D Zhang, J Chojnacki, Y Du, H Fu, S Grant, S Zhang Organic & biomolecular chemistry 11 (29), 4757-4763, 2013 | 98 | 2013 |
Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor J Jiang, T Ganesh, Y Du, P Thepchatri, A Rojas, I Lewis, S Kurtkaya, L Li, ... Proceedings of the National Academy of Sciences 107 (5), 2307-2312, 2010 | 94 | 2010 |
A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation YH Lo, KS Kolahi, Y Du, CY Chang, A Krokhotin, A Nair, WD Sobba, ... Cancer discovery 11 (6), 1562-1581, 2021 | 91 | 2021 |
Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway M Chen, Y Du, M Qui, M Wang, K Chen, Z Huang, M Jiang, F Xiong, ... Oncology reports 29 (2), 430-436, 2013 | 91 | 2013 |
Stress induces p38 MAPK-mediated phosphorylation and inhibition of Drosha-dependent cell survival Q Yang, W Li, H She, J Dou, DM Duong, Y Du, SH Yang, NT Seyfried, ... Molecular cell 57 (4), 721-734, 2015 | 86 | 2015 |
Discovery of dual inhibitors of MDM2 and XIAP for cancer treatment L Gu, H Zhang, T Liu, S Zhou, Y Du, J Xiong, S Yi, CK Qu, H Fu, M Zhou Cancer cell 30 (4), 623-636, 2016 | 77 | 2016 |
Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis JE Aslan, H You, DM Williamson, J Endig, RT Youker, L Thomas, H Shu, ... Molecular cell 34 (4), 497-509, 2009 | 77 | 2009 |