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Gawain McColl
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Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease
DKV Kumar, SH Choi, KJ Washicosky, WA Eimer, S Tucker, J Ghofrani, ...
Science translational medicine 8 (340), 340ra72-340ra72, 2016
10102016
Utility of an improved model of amyloid-beta (Aß1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease
G McColl, BR Roberts, TL Pukala, VB Kenche, CM Roberts, CD Link, ...
Molecular Neurodegeneration 7 (1), 57-57, 2012
2502012
Evolution of lifespan in C. elegans
DW Walker, G McColl, NL Jenkins, J Harris, GJ Lithgow
Nature 405 (6784), 296-297, 2000
2442000
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans
G McColl, DW Killilea, AE Hubbard, MC Vantipalli, S Melov, GJ Lithgow
Journal of Biological Chemistry 283 (1), 350-357, 2008
2262008
Fitness cost of extended lifespan in Caenorhabditis elegans
NL Jenkins, G McColl, GJ Lithgow
Proceedings of the Royal Society of London. Series B: Biological Sciences …, 2004
1952004
Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution
DJ Hare, EJ New, MD de Jonge, G McColl
Chemical Society Reviews 44 (17), 5941-5958, 2015
1772015
Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans
GA Walker, TM White, G McColl, NL Jenkins, S Babich, EPM Candido, ...
The Journals of Gerontology Series A: Biological Sciences and Medical …, 2001
1622001
Response of Two Heat Shock Genes to Selection for Knockdown Heat Resistance in Drosophila melanogaster
G McColl, AA Hoffmann, SW McKechnie
Genetics 143 (4), 1615-1627, 1996
1531996
The Caenorhabditis elegans Aβ1–42 model of Alzheimer disease predominantly expresses Aβ3–42
G McColl, BR Roberts, AP Gunn, KA Perez, DJ Tew, CL Masters, ...
Journal of Biological Chemistry 284 (34), 22697-22702, 2009
1462009
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans
AN Rogers, D Chen, G McColl, G Czerwieniec, K Felkey, BW Gibson, ...
Cell metabolism 14 (1), 55-66, 2011
1352011
Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans
G McColl, AN Rogers, S Alavez, AE Hubbard, S Melov, CD Link, AI Bush, ...
Cell metabolism 12 (3), 260-272, 2010
1172010
Iron, copper, and zinc concentration in Aβ plaques in the APP/PS1 mouse model of Alzheimer’s disease correlates with metal levels in the surrounding neuropil
SA James, QI Churches, MD de Jonge, IE Birchall, V Streltsov, G McColl, ...
ACS chemical neuroscience 8 (3), 629-637, 2017
1142017
An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta
DJ Hare, P Lei, S Ayton, BR Roberts, R Grimm, JL George, DP Bishop, ...
Chemical Science 5 (6), 2160-2169, 2014
1132014
Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans
S James, B Roberts, D Hare, M de Jonge, I Birchall, N Jenkins, R Cherny, ...
Chemical Science 6, 2953-2962, 2015
922015
Stabilization of nontoxic Aβ-oligomers: insights into the mechanism of action of hydroxyquinolines in Alzheimer's disease
TM Ryan, BR Roberts, G McColl, DJ Hare, PA Doble, QX Li, M Lind, ...
Journal of Neuroscience 35 (7), 2871-2884, 2015
882015
Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging
B Paul, DJ Hare, DP Bishop, C Paton, N Cole, MM Niedwiecki, ...
Chemical Science 6 (10), 5383-5393, 2015
842015
Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease
PM Chege, G McColl
Frontiers in Aging Neuroscience 6, 2014
832014
Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans
NL Jenkins, SA James, A Salim, F Sumardy, TP Speed, M Conrad, ...
Elife 9, e56580, 2020
812020
PBT2 reduces toxicity in a C. elegans model of polyQ aggregation and extends lifespan, reduces striatal atrophy and improves motor performance in the R6/2 mouse model of …
RA Cherny, S Ayton, DI Finkelstein, AI Bush, G McColl, SM Massa
Journal of Huntington's Disease 1 (2), 211-219, 2012
712012
Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese
G McColl, SA James, S Mayo, DL Howard, CG Ryan, R Kirkham, ...
PloS one 7 (2), e32685, 2012
602012
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