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Kai Connie Wu
Kai Connie Wu
Senior Scientist, Janssen R&D
Verified email at its.jnj.com
Title
Cited by
Cited by
Year
Beneficial role of Nrf2 in regulating NADPH generation and consumption
KC Wu, JY Cui, CD Klaassen
Toxicological Sciences 123 (2), 590-600, 2011
3662011
Effect of graded Nrf2 activation on phase-I and-II drug metabolizing enzymes and transporters in mouse liver
KC Wu, JY Cui, CD Klaassen
PloS one 7 (7), e39006, 2012
1652012
Nrf2 activation prevents cadmium-induced acute liver injury
KC Wu, JJ Liu, CD Klaassen
Toxicology and applied pharmacology 263 (1), 14-20, 2012
1592012
NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants
J Liu, KC Wu, YF Lu, E Ekuase, CD Klaassen
Oxidative medicine and cellular longevity 2013, 2013
1542013
Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation
KC Wu, J Liu, CD Klaassen
Toxicology and applied pharmacology 262 (3), 321-329, 2012
1462012
Genetic Activation of Nrf2 Protects against Fasting-Induced Oxidative Stress in Livers of Mice
YKJ Zhang, KC Wu, CD Klaassen
PloS one 8 (3), e59122, 2013
1042013
Screening of Natural Compounds as Activators of the Keap1-Nrf2 Pathway
KC Wu, PR McDonald, J Liu, CD Klaassen
Planta medica 80 (01), 97-104, 2014
952014
Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet
YKJ Zhang, KC Wu, J Liu, CD Klaassen
Toxicology and applied pharmacology 264 (3), 305-314, 2012
952012
Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice
J Liu, YF Lu, Y Zhang, KC Wu, F Fan, CD Klaassen
Toxicology and applied pharmacology 272 (3), 816-824, 2013
492013
Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway
KC Wu, PR McDonald, JJ Liu, R Chaguturu, CD Klaassen
Public Library of Science 7 (10), e44686, 2012
462012
Nrf2 protects against diquat-induced liver and lung injury
KC Wu, Y Zhang, CD Klaassen
Free Radical Research 46 (10), 1220-1229, 2012
462012
Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor
J Rooney, K Oshida, N Vasani, B Vallanat, N Ryan, BN Chorley, X Wang, ...
PloS one 13 (8), e0200004, 2018
452018
Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2
YF Lu, J Liu, KC Wu, CD Klaassen
Toxicology letters 232 (1), 326-332, 2015
402015
Overexpression of Nrf2 Protects against Microcystin-Induced Hepatotoxicity in Mice
YF Lu, J Liu, KC Wu, Q Qu, F Fan, CD Klaassen
PLOS ONE 9 (3), e93013, 2014
382014
Structure-based design of potent, selective, and orally bioavailable VPS34 kinase inhibitors
DX Hu, S Patel, H Chen, S Wang, ST Staben, YN Dimitrova, ...
Journal of Medicinal Chemistry 65 (17), 11500-11512, 2021
142021
Dysregulation of the calcium handling protein, CCDC47, is associated with diabetic cardiomyopathy
K Thapa, KC Wu, A Sarma, EM Grund, A Szeto, AJ Mendez, S Gesta, ...
Cell & bioscience 8 (1), 1-13, 2018
142018
RNA-Seq provides new insights on the relative mRNA abundance of antioxidant components during mouse liver development
KC Wu, JY Cui, J Liu, H Lu, X Zhong, CD Klaassen
Free Radical Biology and Medicine 134, 335-342, 2019
102019
Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9
KC Wu, SA Reisman, CD Klaassen
Free radical research 54 (7), 525-534, 2020
62020
Assessment of skin toxicity in an in vitro reconstituted human epidermis model using deep learning
F Hu, SF Santagostino, DM Danilenko, M Tseng, J Brumm, P Zehnder, ...
The American Journal of Pathology 192 (4), 687-700, 2022
52022
Predicting Human Infection Risk: Do Rodent Host Resistance Models Add Value?
KC Wu, Y Zhong, J Maher
Toxicological Sciences 170 (2), 260-272, 2019
22019
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Articles 1–20