| Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells RS Ohgami, DR Campagna, EL Greer, B Antiochos, A McDonald, J Chen, ... Nature genetics 37 (11), 1264-1269, 2005 | 832 | 2005 |
| Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth T Hitosugi, S Kang, MG Vander Heiden, TW Chung, S Elf, K Lythgoe, ... Science signaling 2 (97), ra73-ra73, 2009 | 831 | 2009 |
| Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins L Zhang, J Chen, H Fu Proceedings of the National Academy of Sciences 96 (15), 8511-8515, 1999 | 468 | 1999 |
| Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth T Hitosugi, L Zhou, S Elf, J Fan, HB Kang, JH Seo, C Shan, Q Dai, ... Cancer cell 22 (5), 585-600, 2012 | 425 | 2012 |
| Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism J Chen, K Fujii, L Zhang, T Roberts, H Fu Proceedings of the National Academy of Sciences 98 (14), 7783-7788, 2001 | 397 | 2001 |
| Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia X Gao, SH Lin, F Ren, JT Li, JJ Chen, CB Yao, HB Yang, SX Jiang, ... Nature communications 7 (1), 1-14, 2016 | 365 | 2016 |
| Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism T Hitosugi, J Fan, TW Chung, K Lythgoe, X Wang, J Xie, Q Ge, TL Gu, ... Molecular Cell 44 (6), 864-877, 2011 | 340 | 2011 |
| Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex J Fan, C Shan, HB Kang, S Elf, J Xie, M Tucker, TL Gu, M Aguiar, ... Molecular cell 53 (4), 534-548, 2014 | 286 | 2014 |
| 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling R Lin, S Elf, C Shan, HB Kang, Q Ji, L Zhou, T Hitosugi, L Zhang, S Zhang, ... Nature cell biology 17 (11), 1484-1496, 2015 | 261 | 2015 |
| Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells J Fan, T Hitosugi, TW Chung, J Xie, Q Ge, TL Gu, RD Polakiewicz, ... Molecular and Cellular Biology 31 (24), 4938-4950, 2011 | 253 | 2011 |
| Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation J Wang, C Luo, C Shan, Q You, J Lu, S Elf, Y Zhou, Y Wen, JL Vinkenborg, ... Nature chemistry 7 (12), 968-979, 2015 | 221 | 2015 |
| PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder J Chen, DJ DeAngelo, JL Kutok, IR Williams, BH Lee, M Wadleigh, ... Proceedings of the National Academy of Sciences 101 (40), 14479-14484, 2004 | 212 | 2004 |
| p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells S Kang, S Elf, K Lythgoe, T Hitosugi, J Taunton, W Zhou, L Xiong, D Wang, ... The Journal of clinical investigation 120 (4), 1165-1177, 2010 | 179 | 2010 |
| FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway S Kang, S Dong, TL Gu, A Guo, MS Cohen, S Lonial, HJ Khoury, ... Cancer cell 12 (3), 201-214, 2007 | 162 | 2007 |
| Prevention of dietary-fat-fueled ketogenesis attenuates BRAF V600E tumor growth S Xia, R Lin, L Jin, L Zhao, HB Kang, Y Pan, S Liu, G Qian, Z Qian, ... Cell metabolism 25 (2), 358-373, 2017 | 156 | 2017 |
| Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling HB Kang, J Fan, R Lin, S Elf, Q Ji, L Zhao, L Jin, JH Seo, C Shan, ... Molecular cell 59 (3), 345-358, 2015 | 143 | 2015 |
| The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R D Zhong, L Xiong, T Liu, X Liu, X Liu, J Chen, SY Sun, FR Khuri, Y Zong, ... Journal of Biological Chemistry 284 (35), 23225-23233, 2009 | 141 | 2009 |
| Activation of FIP1L1-PDGFRα requires disruption of the juxtamembrane domain of PDGFRα and is FIP1L1-independent EH Stover, J Chen, C Folens, BH Lee, N Mentens, P Marynen, IR Williams, ... Proceedings of the National Academy of Sciences 103 (21), 8078-8083, 2006 | 141 | 2006 |
| Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth C Shan, S Elf, Q Ji, HB Kang, L Zhou, T Hitosugi, L Jin, R Lin, L Zhang, ... Molecular cell 55 (4), 552-565, 2014 | 139 | 2014 |
| The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRβ and FIP1L1-PDGFRα in vitro and in vivo EH Stover, J Chen, BH Lee, J Cools, E McDowell, J Adelsperger, ... Blood 106 (9), 3206-3213, 2005 | 137 | 2005 |
Fadlo R. KhuriPresident and Professor, American University of BeirutVerified email at aub.edu.lb
