| Rationally engineered Cas9 nucleases with improved specificity IM Slaymaker, L Gao, B Zetsche, DA Scott, WX Yan, F Zhang Science 351 (6268), 84-88, 2016 | 2590 | 2016 |
| Engineered CRISPR-Cas9 nuclease with expanded targeting space H Nishimasu, X Shi, S Ishiguro, L Gao, S Hirano, S Okazaki, T Noda, ... Science 361 (6408), 1259-1262, 2018 | 990 | 2018 |
| Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies PW Tillberg, F Chen, KD Piatkevich, Y Zhao, CC Yu, BP English, L Gao, ... Nature biotechnology 34 (9), 987-992, 2016 | 563 | 2016 |
| Engineered Cpf1 variants with altered PAM specificities L Gao, DBT Cox, WX Yan, JC Manteiga, MW Schneider, T Yamano, ... Nature biotechnology 35 (8), 789-792, 2017 | 452 | 2017 |
| BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks WX Yan, R Mirzazadeh, S Garnerone, D Scott, MW Schneider, T Kallas, ... Nature communications 8 (1), 15058, 2017 | 340 | 2017 |
| Engineering of CRISPR-Cas12b for human genome editing J Strecker, S Jones, B Koopal, J Schmid-Burgk, B Zetsche, L Gao, ... Nature communications 10 (1), 212, 2019 | 334 | 2019 |
| Diverse enzymatic activities mediate antiviral immunity in prokaryotes L Gao, H Altae-Tran, F Böhning, KS Makarova, M Segel, JL Schmid-Burgk, ... Science 369 (6507), 1077-1084, 2020 | 315 | 2020 |
| Highly parallel profiling of Cas9 variant specificity JL Schmid-Burgk, L Gao, D Li, Z Gardner, J Strecker, B Lash, F Zhang Molecular cell 78 (4), 794-800. e8, 2020 | 156 | 2020 |
| Prokaryotic innate immunity through pattern recognition of conserved viral proteins LA Gao, ME Wilkinson, J Strecker, KS Makarova, RK Macrae, EV Koonin, ... Science 377 (6607), eabm4096, 2022 | 94 | 2022 |
| Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons H Tekin, S Simmons, B Cummings, L Gao, X Adiconis, CC Hession, ... Nature Biomedical Engineering 2 (7), 540-554, 2018 | 90 | 2018 |
| Structural basis for the altered PAM recognition by engineered CRISPR-Cpf1 H Nishimasu, T Yamano, L Gao, F Zhang, R Ishitani, O Nureki Molecular cell 67 (1), 139-147. e2, 2017 | 86 | 2017 |
| A highly homogeneous polymer composed of tetrahedron-like monomers for high-isotropy expansion microscopy R Gao, CC Yu, L Gao, KD Piatkevich, RL Neve, JB Munro, S Upadhyayula, ... Nature nanotechnology 16 (6), 698-707, 2021 | 55 | 2021 |
| Unexpected connections between type VI-B CRISPR-Cas systems, bacterial natural competence, ubiquitin signaling network and DNA modification through a distinct family of … KS Makarova, L Gao, F Zhang, EV Koonin FEMS microbiology letters 366 (8), fnz088, 2019 | 16 | 2019 |
| UG/Abi: a highly diverse family of prokaryotic reverse transcriptases associated with defense functions MR Mestre, LA Gao, SA Shah, A López-Beltrán, A González-Delgado, ... Nucleic acids research 50 (11), 6084-6101, 2022 | 11 | 2022 |
| Computational Identification of Repeat-Containing Proteins and Systems H Altae-Tran, L Gao, J Strecker, RK Macrae, F Zhang QRB discovery 1, e10, 2020 | 1 | 2020 |
