| Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex J Chen, B Malone, E Llewellyn, M Grasso, PMM Shelton, PDB Olinares, ... Cell 182 (6), 1560-1573. e13, 2020 | 404 | 2020 |
| Structural basis for NusA stabilized transcriptional pausing X Guo, AG Myasnikov, J Chen, C Crucifix, G Papai, M Takacs, P Schultz, ... Molecular cell 69 (5), 816-827. e4, 2018 | 147 | 2018 |
| Structural basis of transcription arrest by coliphage HK022 Nun in an Escherichia coli RNA polymerase elongation complex JY Kang, PDB Olinares, J Chen, EA Campbell, A Mustaev, BT Chait, ... Elife 6, e25478, 2017 | 119 | 2017 |
| Eliminating effects of particle adsorption to the air/water interface in single-particle cryo-electron microscopy: Bacterial RNA polymerase and CHAPSO J Chen, AJ Noble, JY Kang, SA Darst Journal of structural biology: X 1, 100005, 2019 | 117 | 2019 |
| Time-resolved cryo-EM using Spotiton VP Dandey, WC Budell, H Wei, D Bobe, K Maruthi, M Kopylov, ET Eng, ... Nature methods 17 (9), 897-900, 2020 | 115 | 2020 |
| Stepwise promoter melting by bacterial RNA polymerase J Chen, C Chiu, S Gopalkrishnan, AY Chen, PDB Olinares, RM Saecker, ... Molecular cell 78 (2), 275-288. e6, 2020 | 101 | 2020 |
| Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding H Boyaci, J Chen, R Jansen, SA Darst, EA Campbell Nature 565 (7739), 382-385, 2019 | 97 | 2019 |
| Requirements for catalysis in the Cre recombinase active site B Gibb, K Gupta, K Ghosh, R Sharp, J Chen, GD Van Duyne Nucleic acids research 38 (17), 5817-5832, 2010 | 97 | 2010 |
| Structural basis for backtracking by the SARS-CoV-2 replication–transcription complex B Malone, J Chen, Q Wang, E Llewellyn, YJ Choi, PDB Olinares, X Cao, ... Proceedings of the National Academy of Sciences 118 (19), e2102516118, 2021 | 95 | 2021 |
| Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts H Boyaci, J Chen, M Lilic, M Palka, RA Mooney, R Landick, SA Darst, ... Elife 7, e34823, 2018 | 95 | 2018 |
| Diverse and unified mechanisms of transcription initiation in bacteria J Chen, H Boyaci, EA Campbell Nature Reviews Microbiology 19 (2), 95-109, 2021 | 83 | 2021 |
| 6S RNA mimics B-form DNA to regulate Escherichia coli RNA polymerase J Chen, KM Wassarman, S Feng, K Leon, A Feklistov, JT Winkelman, Z Li, ... Molecular cell 68 (2), 388-397. e6, 2017 | 80 | 2017 |
| CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex B Bae, J Chen, E Davis, K Leon, SA Darst, EA Campbell Elife 4, e08505, 2015 | 76 | 2015 |
| Mycobacterial RNA polymerase forms unstable open promoter complexes that are stabilized by CarD E Davis, J Chen, K Leon, SA Darst, EA Campbell Nucleic acids research 43 (1), 433-445, 2015 | 75 | 2015 |
| E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation J Chen, S Gopalkrishnan, C Chiu, AY Chen, EA Campbell, RL Gourse, ... Elife 8, e49375, 2019 | 61 | 2019 |
| Structural basis for transcription complex disruption by the Mfd translocase JY Kang, E Llewellyn, J Chen, PDB Olinares, J Brewer, BT Chait, ... Elife 10, e62117, 2021 | 42 | 2021 |
| Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex J Chen, Q Wang, B Malone, E Llewellyn, Y Pechersky, K Maruthi, ET Eng, ... Nature Structural & Molecular Biology 29 (3), 250-260, 2022 | 41* | 2022 |
| The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase M Lilic, J Chen, H Boyaci, N Braffman, E Hubin, J Herrmann, R Müller, ... Proceedings of the National Academy of Sciences of the United States of America, 2020 | 30 | 2020 |
| Structural origins of Escherichia coli RNA polymerase open promoter complex stability RM Saecker, J Chen, CE Chiu, B Malone, J Sotiris, M Ebrahim, LY Yen, ... Proceedings of the National Academy of Sciences 118 (40), e2112877118, 2021 | 28 | 2021 |
| Structural basis for substrate selection by the SARS-CoV-2 replicase BF Malone, JK Perry, PDB Olinares, HW Lee, J Chen, TC Appleby, ... Nature 614 (7949), 781-787, 2023 | 26 | 2023 |
