Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles A Biscans, J Caiazzi, N McHugh, V Hariharan, M Muhuri, A Khvorova Molecular Therapy 29 (4), 1382-1394, 2021 | 44 | 2021 |
Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1 SM Davis, VN Hariharan, A Lo, AA Turanov, D Echeverria, J Sousa, ... Molecular Therapy-Nucleic Acids 29, 135-149, 2022 | 18 | 2022 |
Cyclic di‐GMP sensing histidine kinase PdtaS controls mycobacterial adaptation to carbon sources VN Hariharan, R Yadav, C Thakur, A Singh, R Gopinathan, DP Singh, ... The FASEB Journal 35 (4), e21475, 2021 | 17* | 2021 |
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection VN Hariharan, M Shin, CW Chang, D O’Reilly, A Biscans, K Yamada, ... Proceedings of the National Academy of Sciences 120 (11), e2219523120, 2023 | 14 | 2023 |
Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease D O'Reilly, J Belgrad, C Ferguson, A Summers, E Sapp, C McHugh, ... Molecular Therapy 31 (6), 1661-1674, 2023 | 13 | 2023 |
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin Q Tang, HH Fakih, M Zain UI Abideen, SR Hildebrand, K Afshari, ... Nature Communications 14 (1), 7099, 2023 | 10 | 2023 |
Finding hidden females in a crowd: Mate recognition in fig wasps A Krishnan, KA Joshi, A Abraham, S Ayyub, M Lahiry, R Mukherjee, ... Acta oecologica 57, 80-87, 2014 | 10 | 2014 |
Two-Component Signalling Systems of M. tuberculosis: Regulators of Pathogenicity and More R Agrawal, VH Narayan, DK Saini Dynamic Models of Infectious Diseases: Volume 2: Non Vector-Borne Diseases …, 2013 | 5 | 2013 |
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo. K Yamada, VN Hariharan, J Caiazzi, R Miller, C Furguson, E Sapp, ... bioRxiv, 2023 | 4 | 2023 |
Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity HH Fakih, Q Tang, A Summers, M Shin, JE Buchwald, R Gagnon, ... Molecular Therapy-Nucleic Acids 34, 2023 | 2 | 2023 |
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo VN Hariharan, J Caiazzi, R Miller, C Ferguson, E Sapp, H Fakih, Q Tang, ... Research Square, 2023 | 1 | 2023 |
OLIGONUCLEOTIDES FOR SARS-CoV-2 MODULATION A Khvorova, J Watts, Z Kennedy, A Biscans, BM da Cruz Godinho, ... US Patent App. 17/333,839, 2023 | 1 | 2023 |
Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders A Khvorova, VN Hariharan, S Davis, A Biscans, A Karumanchi US Patent App. 18/321,971, 2024 | | 2024 |
A combinatorial approach for achieving CNS-selective RNAi CM Ferguson, BMDC Godinho, D Echeverria, M Hassler, L Vangjeli, ... Nucleic Acids Research, gkae100, 2024 | | 2024 |
Exon 53 skipping of the human dystrophin transcript with different chemically modified AONs in a mouse model for Duchenne muscular dystrophy S Engelbeen, D O'Reilly, D Van De Vijver, I Verhaart, M van Putten, ... EUROPEAN JOURNAL OF HUMAN GENETICS 32, 515-516, 2024 | | 2024 |
Optimized sirna scaffolds A Khvorova, D O'reilly, VN Hariharan, C Lochmann, D Cooper US Patent App. 18/197,948, 2023 | | 2023 |
Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for … S Engelbeen, D O'Reilly, D Van De Vijver, I Verhaart, M van Putten, ... nucleic acid therapeutics 33 (6), 348-360, 2023 | | 2023 |
Oligonucleotides for mecp2 modulation A Khvorova, VN Hariharan US Patent App. 18/094,695, 2023 | | 2023 |
Optimized anti-FLT1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders A Khvorova, VN Hariharan, S Davis, A Biscans, A Karumanchi US Patent 11,702,659, 2023 | | 2023 |
Biochemical and Functional Characterization of the Mycobacterial PdtaS-PdtaR Two Component System VN Hariharan | | 2021 |