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James W. Janetka
James W. Janetka
Professor, Washington University School of Medicine
Verified email at wustl.edu - Homepage
Title
Cited by
Cited by
Year
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
SD Zabludoff, C Deng, MR Grondine, AM Sheehy, S Ashwell, BL Caleb, ...
Molecular cancer therapeutics 7 (9), 2955-2966, 2008
4452008
Treatment and prevention of urinary tract infection with orally active FimH inhibitors
CK Cusumano, JS Pinkner, Z Han, SE Greene, BA Ford, JR Crowley, ...
Science translational medicine 3 (109), 109ra115-109ra115, 2011
3472011
Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
CX Ma, JW Janetka, H Piwnica-Worms
Trends in molecular medicine 17 (2), 88-96, 2011
3052011
Structure-based drug design and optimization of mannoside bacterial FimH antagonists
Z Han, JS Pinkner, B Ford, R Obermann, W Nolan, SA Wildman, D Hobbs, ...
Journal of medicinal chemistry 53 (12), 4779-4792, 2010
2972010
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist
CN Spaulding, RD Klein, S Ruer, AL Kau, HL Schreiber, ZT Cusumano, ...
Nature 546 (7659), 528-532, 2017
2672017
MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A
AG Rocha, A Franco, AM Krezel, JM Rumsey, JM Alberti, WC Knight, ...
Science 360 (6386), 336-341, 2018
2312018
Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control
AM Aronov, Q Tang, G Martinez-Botella, GW Bemis, J Cao, G Chen, ...
Journal of medicinal chemistry 52 (20), 6362-6368, 2009
1852009
Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides
Z Han, JS Pinkner, B Ford, E Chorell, JM Crowley, CK Cusumano, ...
Journal of medicinal chemistry 55 (8), 3945-3959, 2012
1562012
Dynamic combinatorial chemistry: in drug discovery, bioorganic chemistry, and materials science
BL Miller
John Wiley & Sons, 2009
1552009
A FimH Inhibitor Prevents Acute Bladder Infection and Treats Chronic Cystitis Caused by Multidrug-Resistant Uropathogenic Escherichia coli ST131
M Totsika, M Kostakioti, TJ Hannan, M Upton, SA Beatson, JW Janetka, ...
The Journal of infectious diseases 208 (6), 921-928, 2013
1512013
Pyrazole compositions useful as inhibitors of ERK
M Hale, J Janetka, F Maltais, J Cao
US Patent 6,784,195, 2004
1382004
Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors
AM Aronov, C Baker, GW Bemis, J Cao, G Chen, PJ Ford, UA Germann, ...
Journal of medicinal chemistry 50 (6), 1280-1287, 2007
1372007
Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice
PS Guiton, CK Cusumano, KA Kline, KW Dodson, Z Han, JW Janetka, ...
Antimicrobial agents and chemotherapy 56 (9), 4738-4745, 2012
1292012
Pyrazole compositions useful as inhibitors of ERK
M Hale, X Xie, J Green, J Cao, C Baker, F Maltais, J Janetka, G Bemis, ...
US Patent 6,528,509, 2003
1242003
Pyrazole compositions useful as inhibitors of ERK
M Hale, X Xie, J Green, J Cao, C Baker, F Maltais, J Janetka, G Bemis, ...
US Patent 6,528,509, 2003
1242003
Pyrazole compositions useful as inhibitors of ERK
M Hale, X Xie, J Green, J Cao, C Baker, F Maltais, J Janetka, G Bemis, ...
US Patent 6,528,509, 2003
1242003
Pyrazole compositions useful as inhibitors of ERK
M Hale, X Xie, J Green, J Cao, C Baker, F Maltais, J Janetka, G Bemis, ...
US Patent 6,528,509, 2003
1242003
Pyrazole compositions useful as inhibitors of ERK
M Hale, X Xie, J Green, J Cao, C Baker, F Maltais, J Janetka, G Bemis, ...
US Patent 6,528,509, 2003
1242003
Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment
BY Owusu, R Galemmo, J Janetka, L Klampfer
Cancers 9 (4), 35, 2017
1182017
Total synthesis of the cyclic biphenyl ether peptides K-13 and OF4949-III via SNAr macrocyclization of peptidyl ruthenium π-arene complexes
JW Janetka, DH Rich
Journal of the American Chemical Society 119 (28), 6488-6495, 1997
1161997
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