| Neurotoxic reactive astrocytes are induced by activated microglia SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, ... Nature 541 (7638), 481-487, 2017 | 6047 | 2017 |
| Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson’s disease S Kim, SH Kwon, TI Kam, N Panicker, SS Karuppagounder, S Lee, JH Lee, ... Neuron 103 (4), 627-641. e7, 2019 | 1031 | 2019 |
| Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease SP Yun, TI Kam, N Panicker, SM Kim, Y Oh, JS Park, SH Kwon, YJ Park, ... Nature medicine 24 (7), 931-938, 2018 | 844 | 2018 |
| Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 X Mao, MT Ou, SS Karuppagounder, TI Kam, X Yin, Y Xiong, P Ge, ... Science 353 (6307), aah3374, 2016 | 673 | 2016 |
| Poly (ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease TI Kam, X Mao, H Park, SC Chou, SS Karuppagounder, GE Umanah, ... Science 362 (6414), eaat8407, 2018 | 392 | 2018 |
| Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease S Sarkar, E Malovic, DS Harishchandra, S Ghaisas, N Panicker, A Charli, ... npj Parkinson's Disease 3 (1), 30, 2017 | 225 | 2017 |
| Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia N Panicker, S Sarkar, DS Harischandra, M Neal, TI Kam, H Jin, ... Journal of Experimental Medicine 216 (6), 1411-1430, 2019 | 198 | 2019 |
| Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of Parkinson's disease N Panicker, H Saminathan, H Jin, M Neal, DS Harischandra, R Gordon, ... Journal of Neuroscience 35 (27), 10058-10077, 2015 | 149 | 2015 |
| Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein DS Harischandra, D Rokad, ML Neal, S Ghaisas, S Manne, S Sarkar, ... Science signaling 12 (572), eaau4543, 2019 | 146 | 2019 |
| Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease R Gordon, N Singh, V Lawana, A Ghosh, DS Harischandra, H Jin, ... Neurobiology of disease 93, 96-114, 2016 | 98 | 2016 |
| The cell biology of Parkinson’s disease N Panicker, P Ge, VL Dawson, TM Dawson Journal of Cell Biology 220 (4), e202012095, 2021 | 93 | 2021 |
| Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration R Gordon, ML Neal, J Luo, MR Langley, DS Harischandra, N Panicker, ... Nature communications 7 (1), 12932, 2016 | 90 | 2016 |
| Kv1. 3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease S Sarkar, HM Nguyen, E Malovic, J Luo, M Langley, BN Palanisamy, ... The Journal of Clinical Investigation 130 (8), 4195-4212, 2020 | 89 | 2020 |
| Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease H Jin, A Kanthasamy, DS Harischandra, N Kondru, A Ghosh, N Panicker, ... Journal of Biological Chemistry 289 (50), 34743-34767, 2014 | 87 | 2014 |
| Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease N Panicker, TI Kam, H Wang, S Neifert, SC Chou, M Kumar, ... Neuron 110 (15), 2422-2437. e9, 2022 | 80 | 2022 |
| STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy JT Hinkle, J Patel, N Panicker, SS Karuppagounder, D Biswas, ... Proceedings of the National Academy of Sciences 119 (15), e2118819119, 2022 | 77 | 2022 |
| Activation mechanisms of the E3 ubiquitin ligase parkin N Panicker, VL Dawson, TM Dawson Biochemical journal 474 (18), 3075-3086, 2017 | 50 | 2017 |
| Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: relevance to translational research H Saminathan, A Charli, J Luo, N Panicker, R Gordon, JM Hostetter, H Jin, ... European journal of pharmacology 881, 173259, 2020 | 16 | 2020 |
| Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease N Panicker, A Kanthasamy, AG Kanthasamy Aging (Albany NY) 11 (16), 5871, 2019 | 16 | 2019 |
| Inflammasome assembly in neurodegenerative diseases J Singh, ML Habean, N Panicker Trends in Neurosciences, 2023 | 13 | 2023 |
Ted M. DawsonDirector, Institute for Cell Engineering, Professor of Neurology and Neuroscience, JHUSoMVerified email at jhmi.edu
