| Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides L Zhang, T Hashimoto, B Qin, J Hashimoto, I Kozone, T Kawahara, ... Angewandte Chemie International Edition 56 (7), 1740-1745, 2017 | 133 | 2017 |
| Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+ 2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides T Hashimoto, J Hashimoto, K Teruya, T Hirano, K Shin-ya, H Ikeda, H Liu, ... Journal of the American Chemical Society 137 (2), 572-575, 2015 | 116 | 2015 |
| Biosynthesis of quinolidomicin, the largest known macrolide of terrestrial origin: identification and heterologous expression of a biosynthetic gene cluster over 200 kb T Hashimoto, J Hashimoto, I Kozone, K Amagai, T Kawahara, ... Organic letters 20 (24), 7996-7999, 2018 | 40 | 2018 |
| Mechanistic insights into Diels-Alder reactions in natural product biosynthesis T Hashimoto, T Kuzuyama Current opinion in chemical biology 35, 117-123, 2016 | 39 | 2016 |
| In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives K Kudo, T Hashimoto, J Hashimoto, I Kozone, N Kagaya, R Ueoka, ... Nature communications 11 (1), 4022, 2020 | 27 | 2020 |
| Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms A Nara, T Hashimoto, M Komatsu, M Nishiyama, T Kuzuyama, H Ikeda The Journal of Antibiotics 70 (5), 616-624, 2017 | 22 | 2017 |
| Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908 T Hashimoto, I Kozone, J Hashimoto, R Ueoka, N Kagaya, M Fujie, N Sato, ... The Journal of antibiotics 73 (3), 171-174, 2020 | 19 | 2020 |
| Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin T Hashimoto, I Kozone, J Hashimoto, H Suenaga, M Fujie, N Satoh, ... The Journal of Antibiotics 73 (9), 650-654, 2020 | 9 | 2020 |
| A novel oxazole-containing tetraene compound, JBIR-159, produced by heterologous expression of the cryptic trans-AT type polyketide synthase biosynthetic gene cluster T Hashimoto, J Hashimoto, N Kagaya, T Nishimura, H Suenaga, ... The Journal of Antibiotics 74 (5), 354-358, 2021 | 3 | 2021 |
| In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq‐Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont T Hashimoto, H Suenaga, K Amagai, J Hashimoto, I Kozone, S Takahashi, ... Angewandte Chemie 136 (10), e202317805, 2024 | | 2024 |
| Method for producing compound with modified mother nucleus Kazuo Shinya, Haruo Ikeda, Mamoru Komatsu, Junko Hashimoto, Ikuko Kozone ... US Patent 20220090100A1, 2022 | | 2022 |
| A novel methymycin analog, 12-ketomethymycin N-oxide, produced by the heterologous expression of the large pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp … R Ueoka, J Hashimoto, I Kozone, T Hashimoto, K Kudo, N Kagaya, ... Bioscience, Biotechnology, and Biochemistry 85 (4), 890-894, 2021 | | 2021 |
| 母核改変された化合物の製造方法 新家一男, 池田治生, 小松護, 橋本絢子, 小曽根郁子, 橋本拓哉, 工藤慧 WO Patent WO2020158839A1, 2020 | | 2020 |
| [4+2]-環化付加反応によるポリケタイド大環状化機構の発見 葛山智久、橋本拓哉、 バイオサイエンスとインダストリー 73 (5), 380-382, 2015 | | 2015 |
| Identification of an enzyme-catalyzed [4+ 2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides T Hashimoto 2015 SIMB Annual Meeting and Exhibition, 2015 | | 2015 |
Kazuo Shin-yaNational Institute of Advanced Industrial Science and TechnologyVerified email at aist.go.jp
