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David A. Six
David A. Six
Venatorx Pharmaceuticals, Inc.
Verified email at venatorx.com - Homepage
Title
Cited by
Cited by
Year
The expanding superfamily of phospholipase A2 enzymes: classification and characterization
DA Six, EA Dennis
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2000
17922000
Lipidomics reveals a remarkable diversity of lipids in human plasma
O Quehenberger, AM Armando, AH Brown, SB Milne, DS Myers, ...
Journal of lipid research 51 (11), 3299-3305, 2010
12952010
Discovery of new biosynthetic pathways: the lipid A story
CRH Raetz, Z Guan, BO Ingram, DA Six, F Song, X Wang, J Zhao
Journal of lipid research 50 (Supplement), S103-S108, 2009
2702009
In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors
RM Phillips, DA Six, EA Dennis, P Ghosh
Journal of Biological Chemistry 278 (42), 41326-41332, 2003
2322003
Group IV cytosolic phospholipase A2 binds with high affinity and specificity to phosphatidylinositol 4, 5-bisphosphate resulting in dramatic increases in activity
M Mosior, DA Six, EA Dennis
Journal of Biological Chemistry 273 (4), 2184-2191, 1998
2271998
VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and …
JC Hamrick, JD Docquier, T Uehara, CL Myers, DA Six, CL Chatwin, ...
Antimicrobial Agents and Chemotherapy 64 (3), 10.1128/aac. 01963-19, 2020
1532020
Inhibition of Group IVA Cytosolic Phospholipase A2 by Novel 2-Oxoamides in Vitro, in Cells, and in Vivo
G Kokotos, DA Six, V Loukas, T Smith, V Constantinou-Kokotou, ...
Journal of medicinal chemistry 47 (14), 3615-3628, 2004
1092004
Novel 2-Oxoamide Inhibitors of Human Group IVA Phospholipase A2
G Kokotos, S Kotsovolou, DA Six, V Constantinou-Kokotou, CC Beltzner, ...
Journal of medicinal chemistry 45 (14), 2891-2893, 2002
1052002
Essential Ca2+-independent role of the group IVA cytosolic phospholipase A2 C2 domain for interfacial activity
DA Six, EA Dennis
Journal of Biological Chemistry 278 (26), 23842-23850, 2003
1042003
Structure−Activity Relationship of 2-Oxoamide Inhibition of Group IVA Cytosolic Phospholipase A2 and Group V Secreted Phospholipase A2
DA Six, E Barbayianni, V Loukas, V Constantinou-Kokotou, ...
Journal of medicinal chemistry 50 (17), 4222-4235, 2007
992007
Subcellular Chemical Imaging of Antibiotics in Single Bacteria Using C60-Secondary Ion Mass Spectrometry
H Tian, DA Six, T Krucker, JA Leeds, N Winograd
Analytical chemistry 89 (9), 5050-5057, 2017
962017
Salmonella synthesizing 1-monophosphorylated lipopolysaccharide exhibits low endotoxic activity while retaining its immunogenicity
Q Kong, DA Six, KL Roland, Q Liu, L Gu, CM Reynolds, X Wang, ...
The Journal of immunology 187 (1), 412-423, 2011
872011
Phosphate groups of lipid A are essential for Salmonella enterica serovar Typhimurium virulence and affect innate and adaptive immunity
Q Kong, DA Six, Q Liu, L Gu, S Wang, P Alamuri, CRH Raetz, R Curtiss III
Infection and immunity 80 (9), 3215-3224, 2012
822012
Characterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid …
J Bojkovic, DL Richie, DA Six, CM Rath, WS Sawyer, Q Hu, CR Dean
Journal of bacteriology 198 (4), 731-741, 2015
742015
Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics
PE Klebba, SMC Newton, DA Six, A Kumar, T Yang, BL Nairn, C Munger, ...
Chemical reviews 121 (9), 5193-5239, 2021
682021
Complex transcriptional and post‐transcriptional regulation of an enzyme for lipopolysaccharide modification
K Moon, DA Six, HJ Lee, CRH Raetz, S Gottesman
Molecular microbiology 89 (1), 52-64, 2013
602013
Differential Inhibition of Group IVA and Group VIA Phospholipases A2 by 2-Oxoamides
D Stephens, E Barbayianni, V Constantinou-Kokotou, A Peristeraki, ...
Journal of medicinal chemistry 49 (9), 2821-2828, 2006
582006
Lipopolysaccharide (LPS) inner-core phosphates are required for complete LPS synthesis and transport to the outer membrane in Pseudomonas aeruginosa PAO1
AM DeLucia, DA Six, RE Caughlan, P Gee, I Hunt, JS Lam, CR Dean
MBio 2 (4), e00142-11, 2011
572011
Palmitoylation State Impacts Induction of Innate and Acquired Immunity by the Salmonella enterica Serovar Typhimurium msbB Mutant
Q Kong, DA Six, Q Liu, L Gu, KL Roland, CRH Raetz, R Curtiss III
Infection and immunity 79 (12), 5027-5038, 2011
552011
Purification and Mutagenesis of LpxL, the Lauroyltransferase of Escherichia coli Lipid A Biosynthesis
DA Six, SM Carty, Z Guan, CRH Raetz
Biochemistry 47 (33), 8623-8637, 2008
532008
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