| Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway JS Lee, TB Kallehauge, LE Pedersen, HF Kildegaard Scientific reports 5 (1), 8572, 2015 | 241 | 2015 |
| A consensus genome-scale reconstruction of Chinese hamster ovary cell metabolism H Hefzi, KS Ang, M Hanscho, A Bordbar, D Ruckerbauer, M Lakshmanan, ... Cell systems 3 (5), 434-443. e8, 2016 | 238 | 2016 |
| One‐step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment LM Grav, JS Lee, S Gerling, TB Kallehauge, AH Hansen, S Kol, GM Lee, ... Biotechnology journal 10 (9), 1446-1456, 2015 | 151 | 2015 |
| CRISPR/Cas9‐mediated genome engineering of CHO cell factories: Application and perspectives JS Lee, LM Grav, NE Lewis, H Faustrup Kildegaard Biotechnology journal 10 (7), 979-994, 2015 | 140 | 2015 |
| Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin YH Sung, JS Lee, SH Park, J Koo, GM Lee Metabolic engineering 9 (5-6), 452-464, 2007 | 97 | 2007 |
| Accelerated homology‐directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment JS Lee, LM Grav, LE Pedersen, GM Lee, HF Kildegaard Biotechnology and bioengineering 113 (11), 2518-2523, 2016 | 83 | 2016 |
| Anti‐cell death engineering of CHO cells: Co‐overexpression of Bcl‐2 for apoptosis inhibition, Beclin‐1 for autophagy induction JS Lee, TK Ha, JH Park, GM Lee Biotechnology and bioengineering 110 (8), 2195-2207, 2013 | 73 | 2013 |
| Minimizing clonal variation during mammalian cell line engineering for improved systems biology data generation LM Grav, D Sergeeva, JS Lee, I Marin de Mas, NE Lewis, MR Andersen, ... ACS Synthetic Biology 7 (9), 2148-2159, 2018 | 69 | 2018 |
| Mitigating clonal variation in recombinant mammalian cell lines JS Lee, HF Kildegaard, NE Lewis, GM Lee Trends in biotechnology 37 (9), 931-942, 2019 | 58 | 2019 |
| Rapamycin treatment inhibits CHO cell death in a serum‐free suspension culture by autophagy induction JS Lee, GM Lee Biotechnology and bioengineering 109 (12), 3093-3102, 2012 | 55 | 2012 |
| Monitoring of autophagy in Chinese hamster ovary cells using flow cytometry JS Lee, GM Lee Methods 56 (3), 375-382, 2012 | 55 | 2012 |
| Effect of sodium butyrate on autophagy and apoptosis in Chinese hamster ovary cells J Seong Lee, GM Lee Biotechnology progress 28 (2), 349-357, 2012 | 50 | 2012 |
| Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing JS Lee, JH Park, TK Ha, M Samoudi, NE Lewis, BO Palsson, ... ACS Synthetic Biology 7 (12), 2867-2878, 2018 | 49 | 2018 |
| Autophagy and apoptosis of recombinant Chinese hamster ovary cells during fed‐batch culture: Effect of nutrient supplementation YK Han, TK Ha, SJ Lee, JS Lee, GM Lee Biotechnology and bioengineering 108 (9), 2182-2192, 2011 | 49 | 2011 |
| Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference K Xiong, KF Marquart, KJ la Cour Karottki, S Li, I Shamie, JS Lee, ... Biotechnology and bioengineering 116 (7), 1813-1819, 2019 | 45 | 2019 |
| Autophagy and its implication in Chinese hamster ovary cell culture YJ Kim, E Baek, JS Lee, GM Lee Biotechnology letters 35, 1753-1763, 2013 | 43 | 2013 |
| Current state and perspectives on erythropoietin production JS Lee, TK Ha, SJ Lee, GM Lee Applied Microbiology and Biotechnology 95, 1405-1416, 2012 | 43 | 2012 |
| Awakening dormant glycosyltransferases in CHO cells with CRISPRa KJC Karottki, H Hefzi, K Xiong, I Shamie, AH Hansen, S Li, LE Pedersen, ... Biotechnology and bioengineering 117 (2), 593-598, 2020 | 35 | 2020 |
| Comprehensive analysis of genomic safe harbors as target sites for stable expression of the heterologous gene in HEK293 cells S Shin, SH Kim, SW Shin, LM Grav, LE Pedersen, JS Lee, GM Lee ACS Synthetic Biology 9 (6), 1263-1269, 2020 | 32 | 2020 |
| Application of CRISPR/Cas9 genome editing to improve recombinant protein production in CHO cells LM Grav, KJ la Cour Karottki, JS Lee, HF Kildegaard Heterologous Protein Production in CHO Cells: Methods and Protocols, 101-118, 2017 | 32 | 2017 |
Gyun Min LeeProfessor of Biological Sciences, KAISTkaist.ac.kr의 이메일 확인됨
