| κ opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses JP McLaughlin, M Marton-Popovici, C Chavkin Journal of Neuroscience 23 (13), 5674-5683, 2003 | 567 | 2003 |
| Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism, which do not recruit β-arrestin-2 A Váradi, GF Marrone, TC Palmer, A Narayan, MR Szabó, V Le Rouzic, ... Journal of medicinal chemistry 59 (18), 8381-8397, 2016 | 297 | 2016 |
| Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system JP McLaughlin, S Li, J Valdez, TA Chavkin, C Chavkin Neuropsychopharmacology 31 (6), 1241-1248, 2006 | 272 | 2006 |
| Prior activation of kappa opioid receptors by U50, 488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning JP McLaughlin, BB Land, S Li, JE Pintar, C Chavkin Neuropsychopharmacology 31 (4), 787-794, 2006 | 238 | 2006 |
| Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids W Xie, GM Samoriski, JP McLaughlin, VA Romoser, A Smrcka, PM Hinkle, ... Proceedings of the National Academy of Sciences 96 (18), 10385-10390, 1999 | 192 | 1999 |
| Neuropathic pain activates the endogenous κ opioid system in mouse spinal cord and induces opioid receptor tolerance M Xu, M Petraschka, JP McLaughlin, RE Westenbroek, MG Caron, ... Journal of Neuroscience 24 (19), 4576-4584, 2004 | 187 | 2004 |
| Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn AN Carey, K Borozny, JV Aldrich, JP McLaughlin European journal of pharmacology 569 (1-2), 84-89, 2007 | 152 | 2007 |
| Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration RE Sperling, SM Gomes, EI Sypek, AN Carey, JP McLaughlin Psychopharmacology 210 (2), 199-209, 2010 | 151 | 2010 |
| Peptide kappa opioid receptor ligands: potential for drug development JV Aldrich, JP McLaughlin The AAPS journal 11 (2), 312-322, 2009 | 149 | 2009 |
| Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse AN Carey, EI Sypek, HD Singh, MJ Kaufman, JP McLaughlin Behavioural brain research 229 (1), 48-56, 2012 | 148 | 2012 |
| Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance JP McLaughlin, LC Myers, PE Zarek, MG Caron, RJ Lefkowitz, TA Czyzyk, ... Journal of Biological Chemistry 279 (3), 1810-1818, 2004 | 139 | 2004 |
| Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence BM Walker, GR Valdez, JP McLaughlin, G Bakalkin Alcohol 46 (4), 359-370, 2012 | 119 | 2012 |
| Endogenous κ opioid activation mediates stress-induced deficits in learning and memory AN Carey, AM Lyons, CF Shay, O Dunton, JP McLaughlin Journal of Neuroscience 29 (13), 4293-4300, 2009 | 116 | 2009 |
| Phosphorylation of a carboxyl-terminal serine within the κ-opioid receptor produces desensitization and internalization JP McLaughlin, M Xu, K Mackie, C Chavkin Journal of Biological Chemistry 278 (36), 34631-34640, 2003 | 114 | 2003 |
| Regulation of opioid receptor function by chronic agonist exposure: constitutive activity and desensitization C Chavkin, JP McLaughlin, JP Celver Molecular pharmacology 60 (1), 20-25, 2001 | 105 | 2001 |
| Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception L Toll, TV Khroyan, K Sonmez, A Ozawa, I Lindberg, JP McLaughlin, ... The FASEB journal 26 (2), 947, 2012 | 101 | 2012 |
| Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action JV Aldrich, KA Patkar, JP McLaughlin Proceedings of the National Academy of Sciences 106 (43), 18396-18401, 2009 | 93 | 2009 |
| Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat JJ Paris, HD Singh, ML Ganno, P Jackson, JP McLaughlin Psychopharmacology 231 (11), 2349-2360, 2014 | 76 | 2014 |
| Effects of conditional central expression of HIV-1 tat protein to potentiate cocaine-mediated psychostimulation and reward among male mice JJ Paris, AN Carey, CF Shay, SM Gomes, JJ He, JP McLaughlin Neuropsychopharmacology 39 (2), 380-388, 2014 | 69 | 2014 |
| Pharmacological characterization of 2-methyl-N-((2′-(pyrrolidin-1-ylsulfonyl) biphenyl-4-yl) methyl) propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ … S Grimwood, Y Lu, AW Schmidt, MA Vanase-Frawley, A Sawant-Basak, ... Journal of Pharmacology and Experimental Therapeutics 339 (2), 555-566, 2011 | 69 | 2011 |
